Medical Image Analysis

Special Issue Editors


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Guest Editor
ETH Zurich, Computer-assisted Applications in Medicine, Computer Vision Lab, ETF C107, Sternwartstrasse 7, CH-8092 Zurich, Switzerland
Interests: medical image analysis; patient-specific modelling; machine learning; image-guided therapy; ultrasound imaging; tissue biomechanical characterization; and medical simulation in virtual-reality

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Guest Editor
ETH Zurich , Computer Vision Lab, Sternwartstrasse 7, Zurich CH-8092, Switzerland
Interests: medical image processing; motion estimation and prediction; machine learning

Special Issue Information

Dear Colleagues,

Medical Image Analysis has commonly enjoyed leveraging and incorporating techniques from the wider field of Computer Vision. On the one hand, compared to natural images (photography), medical images often present relatively lower variability of anatomy, orientation, and field-of-view; on the other hand, clinical applications necessitate much stricter requirements on accuracy. In many fields, recent neural-network based end-to-end machine learning approaches have shown great success and have had a remarkable impact, especially thanks to availability of large annotated datasets. Their effects in Medical Image Analysis are also prominent, although the lack of large, curated, annotated datasets and sometimes prohibitive 3D data sizes may pose limitations.

In this Special Issue, we aim to cover recent advances and applications in Medical Image Analysis. We are particularly interested in exploring novel applications of machine and deep learning approaches, although submissions are open to wider range of medical image processing topics. Some potential areas of interest include methods for dealing with low-number (lack) of annotations; optimal/efficient approaches to procure annotations; scalable methods for multi-organ, multi-tissue analysis applications; approaches to deal with non-normalized sequences/imaging data; and techniques to bring in population information.

We welcome submissions on topics including, but not limited to, the following:

  • Novel applications of deep or machine learning
  • Applications in medical imaging, acquisition, reconstruction, denoising, super-resolution, segmentation, registration, tracking, and others
  • Novel medical imaging techniques and markers
  • Applications in different medical image modalities, including MR, X-ray, PET, US imaging (but excluding biological or microscopy imaging)
Dr. Orcun Goksel
Dr. Christine Tanner
Guest Editors

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Keywords

  • Image processing
  • Machine learning
  • Segmentation
  • Registration
  • Computer aided diagnosis
  • Deep neural networks
  • Interactive applications
  • Image reconstruction

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Published Papers (2 papers)

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Research

24 pages, 2247 KiB  
Article
Multi-Modal Medical Image Registration with Full or Partial Data: A Manifold Learning Approach
by Fereshteh S. Bashiri, Ahmadreza Baghaie, Reihaneh Rostami, Zeyun Yu and Roshan M. D’Souza
J. Imaging 2019, 5(1), 5; https://doi.org/10.3390/jimaging5010005 - 30 Dec 2018
Cited by 34 | Viewed by 10238
Abstract
Multi-modal image registration is the primary step in integrating information stored in two or more images, which are captured using multiple imaging modalities. In addition to intensity variations and structural differences between images, they may have partial or full overlap, which adds an [...] Read more.
Multi-modal image registration is the primary step in integrating information stored in two or more images, which are captured using multiple imaging modalities. In addition to intensity variations and structural differences between images, they may have partial or full overlap, which adds an extra hurdle to the success of registration process. In this contribution, we propose a multi-modal to mono-modal transformation method that facilitates direct application of well-founded mono-modal registration methods in order to obtain accurate alignment of multi-modal images in both cases, with complete (full) and incomplete (partial) overlap. The proposed transformation facilitates recovering strong scales, rotations, and translations. We explain the method thoroughly and discuss the choice of parameters. For evaluation purposes, the effectiveness of the proposed method is examined and compared with widely used information theory-based techniques using simulated and clinical human brain images with full data. Using RIRE dataset, mean absolute error of 1.37, 1.00, and 1.41 mm are obtained for registering CT images with PD-, T1-, and T2-MRIs, respectively. In the end, we empirically investigate the efficacy of the proposed transformation in registering multi-modal partially overlapped images. Full article
(This article belongs to the Special Issue Medical Image Analysis)
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19 pages, 5364 KiB  
Article
Faster R-CNN-Based Glomerular Detection in Multistained Human Whole Slide Images
by Yoshimasa Kawazoe, Kiminori Shimamoto, Ryohei Yamaguchi, Yukako Shintani-Domoto, Hiroshi Uozaki, Masashi Fukayama and Kazuhiko Ohe
J. Imaging 2018, 4(7), 91; https://doi.org/10.3390/jimaging4070091 - 4 Jul 2018
Cited by 60 | Viewed by 10075
Abstract
The detection of objects of interest in high-resolution digital pathological images is a key part of diagnosis and is a labor-intensive task for pathologists. In this paper, we describe a Faster R-CNN-based approach for the detection of glomeruli in multistained whole slide images [...] Read more.
The detection of objects of interest in high-resolution digital pathological images is a key part of diagnosis and is a labor-intensive task for pathologists. In this paper, we describe a Faster R-CNN-based approach for the detection of glomeruli in multistained whole slide images (WSIs) of human renal tissue sections. Faster R-CNN is a state-of-the-art general object detection method based on a convolutional neural network, which simultaneously proposes object bounds and objectness scores at each point in an image. The method takes an image obtained from a WSI with a sliding window and classifies and localizes every glomerulus in the image by drawing the bounding boxes. We configured Faster R-CNN with a pretrained Inception-ResNet model and retrained it to be adapted to our task, then evaluated it based on a large dataset consisting of more than 33,000 annotated glomeruli obtained from 800 WSIs. The results showed the approach produces comparable or higher than average F-measures with different stains compared to other recently published approaches. This approach could have practical application in hospitals and laboratories for the quantitative analysis of glomeruli in WSIs and, potentially, lead to a better understanding of chronic glomerulonephritis. Full article
(This article belongs to the Special Issue Medical Image Analysis)
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