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Cryptococcus Infections and Pathogenesis
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Cryptococcus Infections and Pathogenesis

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Pathogenesis and Disease Control".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 603

Special Issue Editor

Dr. Erin McClelland

E-Mail Website
Guest Editor
College of Osteopathic Medicine, Marian University, Indianapolis, IN 46222, USA
Interests: cryptococcus neoformans; medical mycology; host-pathogen interactions; gender-specific differences to infection
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The Cryptococcus species cause infections in a variety of hosts and while many discoveries shed light on how infection and disease occur, more remains to be discovered. For this Special Issue, we invite original research articles or review papers on all aspects of Cryptococcus infections and pathogenesis. Potential topics include but are not limited to: microbial virulence factors involved in infection/pathogenesis, host responses that affect infection/pathogenesis, host‒pathogen interactions, Cryptococcus transmission, antifungal therapies, and alternative disease models. We look forward to reading your contributions.

Dr. Erin McClelland
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cryptococcus
  • cryptococcosis
  • infection
  • host immune responses
  • virulence
  • pathogenesis
  • host-pathogen interactions
  • antifungal therapy

Published Papers (1 paper)

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Research

20 pages, 6852 KiB  
Article
Inhibition of Microbicidal Activity of Canine Macrophages DH82 Cell Line by Capsular Polysaccharides from Cryptococcus neoformans
by Isabel F. LaRocque-de-Freitas, Elias Barbosa da Silva-Junior, Leticia Paixão Gemieski, Beatriz da Silva Dias Lima, Israel Diniz-Lima, Aislan de Carvalho Vivarini, Ulisses G. Lopes, Leonardo Freire-de-Lima, Alexandre Morrot, José Osvaldo Previato, Lucia Mendonça-Previato, Lucia Helena Pinto-da-Silva, Celio G. Freire-de-Lima and Debora Decote-Ricardo
J. Fungi 2024, 10(5), 339; https://doi.org/10.3390/jof10050339 - 8 May 2024
Viewed by 98
Abstract
Cryptococcus neoformans is a lethal fungus that primarily affects the respiratory system and the central nervous system. One of the main virulence factors is the capsule, constituted by the polysaccharides glucuronoxylomannan (GXM) and glucuronoxylomanogalactan (GXMGal). Polysaccharides are immunomodulators. One of the target cell [...] Read more.
Cryptococcus neoformans is a lethal fungus that primarily affects the respiratory system and the central nervous system. One of the main virulence factors is the capsule, constituted by the polysaccharides glucuronoxylomannan (GXM) and glucuronoxylomanogalactan (GXMGal). Polysaccharides are immunomodulators. One of the target cell populations for modulation are macrophages, which are part of the first line of defense and important for innate and adaptive immunity. It has been reported that macrophages can be modulated to act as a “Trojan horse,” taking phagocytosed yeasts to strategic sites or having their machinery activation compromised. The scarcity of information on canine cryptococcosis led us to assess whether the purified capsular polysaccharides from C. neoformans would be able to modulate the microbicidal action of macrophages. In the present study, we observed that the capsular polysaccharides, GXM, GXMGal, or capsule total did not induce apoptosis in the DH82 macrophage cell line. However, it was possible to demonstrate that the phagocytic activity was decreased after treatment with polysaccharides. In addition, recovered yeasts from macrophages treated with polysaccharides after phagocytosis could be cultured, showing that their viability was not altered. The polysaccharides led to a reduction in ROS production and the mRNA expression of IL-12 and IL-6. We observed that GXMGal inhibits MHC class II expression and GXM reduces ERK phosphorylation. In contrast, GXMGal and GXM were able to increase the PPAR-γ expression. Furthermore, our data suggest that capsular polysaccharides can reduce the microbicidal activity of canine macrophages DH82. Full article
(This article belongs to the Special Issue Cryptococcus Infections and Pathogenesis)
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