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New Advances in Personalized Tissue Engineering: A Focus on Bone,...
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New Advances in Personalized Tissue Engineering: A Focus on Bone, Cartilage, and Blood Vessel Regeneration

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Regenerative Medicine and Therapeutics".

Deadline for manuscript submissions: 23 August 2024 | Viewed by 1208

Special Issue Editors

Dr. Juncen Zhou

E-Mail Website
Guest Editor
Department of Biomedical Engineering, University of Stony Brook, Stony Brook, NY 11794, USA
Interests: bioresorbable materials; surface functionalization; orthopedic implants; bone defect treatment; bioresorbable metals; 3D printing
Dr. Xin Liu

E-Mail Website
Guest Editor
Department of Dental Materials, Shanghai Biomaterials Research and Testing Center, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Interests: biomaterials; bioactive glasses; dental materials; tissue regeneration; cancer treatment; biological evaluation; antibacterial nanomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Tissue engineering holds immense potential for regenerative medicine, aiming to restore various damaged tissues. However, achieving optimal outcomes through standard treatments remains challenging due to the intricate, patient-specific nature of tissue regeneration. Personalized tissue engineering can bridge this gap.

In this Special Issue, we will delve into three tissue types:

  1. Bone: Bone tissue engineering addresses the high demand for bone grafts in various conditions. Personalized strategies can enhance graft integration and outcomes.
  2. Cartilage: Cartilage's avascular nature makes regeneration difficult. Personalized tissue engineering offers solutions for patient-specific conditions like osteoarthritis.
  3. Blood Vessels: Personalized blood vessel tissue engineering caters to the distinct graft requirements of cardiovascular disease patients, considering diverse diameters and properties.

Personalization in tissue engineering can be seen in various stages, such as tissue defect imaging, structural design, biomaterial development, fabrication methods, and cell seeding. Each plays a unique role in delivering patient-specific treatment.

This Special Issue will present cutting-edge developments in Personalized Tissue Engineering for these areas. Content will include original research, reviews, and communications. Our goal is to deepen the understanding of personalization in tissue engineering and provide insights for future clinical applications.

Dr. Juncen Zhou
Dr. Xin Liu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tissue engineering
  • personalized
  • regenerative medicine
  • bone
  • cartilage
  • blood vessels
  • bioresorbable
  • in vivo

Published Papers (1 paper)

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Research

13 pages, 1380 KiB  
Article
Comparison of the Efficacy of Human Umbilical Cord-Derived and Bone Marrow Aspirate Concentrate Mesenchymal Stem Cells for Cartilage Repair Defects of the Knee via Arthroscopic Implementation on Scaffolds in a Retrospective Study
by Karol Pałka, Bogusław Sadlik, Paweł Kamiński, Rafał J. Bułdak and Michał Dobrakowski
J. Pers. Med. 2024, 14(3), 220; https://doi.org/10.3390/jpm14030220 - 20 Feb 2024
Viewed by 961
Abstract
Injuries to the articular cartilage of the human knee joint, commonly resulting from trauma, inflammation, or age- and activity-related wear and tear, have significant implications, primarily leading to osteoarthritis (OA). Conservative treatments for such injuries often yield suboptimal clinical outcomes. Surgical interventions using [...] Read more.
Injuries to the articular cartilage of the human knee joint, commonly resulting from trauma, inflammation, or age- and activity-related wear and tear, have significant implications, primarily leading to osteoarthritis (OA). Conservative treatments for such injuries often yield suboptimal clinical outcomes. Surgical interventions using current methods may not consistently provide satisfactory results, largely due to the formation of low-quality scar tissue lacking the biomechanical properties of hyaline cartilage. In this retrospective study, we compared the results of two promising methods for regenerating cartilage defects in the knee joints using scaffolds soaked with stem cells of different origins: bone marrow aspirate concentrate mesenchymal stem cells (BMAC-MSCs) and human umbilical cord-derived mesenchymal stem cells (hUCB-MSCs). We evaluated 39 patients (39 knees, hUCB-MSCs: 20 knees, BMAC: 19 knees) at the 12-month follow-up using VAS, KOOS, Lysholm scales and radiologically with M-MOCART 2.0 score. The analysis demonstrated substantial overall improvement in both groups, notably reflected in enhanced quality of life for the patients. Interestingly, the final scores in the hUCB-MSCs group were comparable to those in the BMAC-MSCs group, with no statistically significant differences observed, despite variations in preoperative age and lesion size. Notably, the hUCB-MSCs group consisted of significantly older individuals with larger lesion sizes. Both procedures were found to be safe, and improvement was observed in both groups, which holds promise for future clinical investigations. Full article
(This article belongs to the Special Issue New Advances in Personalized Tissue Engineering: A Focus on Bone, Cartilage, and Blood Vessel Regeneration)
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