Bioinformatics and Computational Biology in Personalized Medicine

Dear Colleagues,

The increasing complexity and volume of data in clinical research—from omics and imaging to real-world evidence—presents both unprecedented opportunities and significant challenges. Reproducibility, data quality, and scalability are critical issues that must be addressed to translate these vast datasets into actionable insights for patients. This requires a dedicated focus on the informatics infrastructure and methodologies that underpin modern clinical research.

This Special Issue is dedicated to cutting-edge research in data science, bioinformatics, and computational biology as applied to clinical research. We are looking for original research articles and comprehensive reviews that focus on developing reproducible workflows from the data lake to discovery, including data quality control, validation, and adherence to FAIR (Findable, Accessible, Interoperable, Reusable) data principles.

We welcome contributions on novel approaches for data integration, statistical modelling, machine learning, and deep learning to enable biomarker discovery, patient stratification, and a deeper understanding of disease mechanisms. This issue will highlight how these advanced computational approaches can drive progress across all areas of clinical research, including the use of causal analysis in non-randomized studies (non-RCTs) to derive robust insights from observational data.

Dr. Umar Niazi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.