Personalized Medicine and Other Emerging Therapy in Hematologic Malignancies

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".

Deadline for manuscript submissions: closed (15 May 2024) | Viewed by 1202

Special Issue Editor


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Guest Editor
Department of Head and Neck Oncology, Gustave Roussy Cancer Campus, Villejuif, France
Interests: haematology; oncology; descriptive studies; Middle East; epidemiologic studies; cohort studies; clinical studies; middle east studies; observational studies

Special Issue Information

Dear Colleagues,

Hematologic malignancies are cancers that originate in hematopoietic tissues (such as bone marrow) or cells of the immune system. There are three main types of hematological malignancies: leukemia, lymphoma, and multiple myeloma. There are increasing reports that hematological malignancies, such as leukemia and lymphoma, afflict millions of adults and children every year, and are often deadly. Therefore, it is increasingly urgent to explore emerging therapy methods to treat hematologic malignancies.

This Special Issue will focus a broad range of innovative treatments, including bispecific antibodies, new monoclonal antibodies, CAR-T cells, small molecules in targeted cancer therapy, immunoconjugates, targeted drugs, immunotherapy, tyrosine kinase inhibitors, amongst others.

This Special Issue aims to provide a discussion platform for the diagnosis and treatment of hematological malignancies in personalized medicine and to promote academic exchanges and experience sharing of personalized medicine in hematological malignancies. In this Special Issue, we aim to focus on personalized medicine for hematologic malignancies; original research articles, review articles, etc., are welcome.

Dr. Khalil Saleh
Guest Editor

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Keywords

  • hematologic malignancies
  • CAR-T cells
  • targeted cancer therapy
  • personalized medicine
  • immunotherapy
  • bispecific antibodies

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Published Papers (1 paper)

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Review

13 pages, 248 KiB  
Review
The Evolving Role of Bispecific Antibodies in Diffuse Large B-Cell Lymphoma
by Khalil Saleh, Rita Khoury, Nadine Khalife, Claude Chahine, Rebecca Ibrahim, Zamzam Tikriti and Axel Le Cesne
J. Pers. Med. 2024, 14(7), 666; https://doi.org/10.3390/jpm14070666 - 21 Jun 2024
Viewed by 916
Abstract
The advent of targeted therapies such as monoclonal antibodies, adoptive T-cell therapies, and antibody–drug conjugates (ADCs) dramatically changed the treatment landscape of diffuse large B-cell lymphoma (DLBCL) over the last two decades. Rituximab was the first one approved. Chimeric antigen receptor T-cells are [...] Read more.
The advent of targeted therapies such as monoclonal antibodies, adoptive T-cell therapies, and antibody–drug conjugates (ADCs) dramatically changed the treatment landscape of diffuse large B-cell lymphoma (DLBCL) over the last two decades. Rituximab was the first one approved. Chimeric antigen receptor T-cells are currently approved as second-line treatment in patients with DLBCL refractory to first-line chemo-immunotherapy. Polatuzumab, a CD79b-targeting ADC, is approved as first-line treatment in high-risk patients in combination with chemo-immunotherapy. Bispecific antibodies (BsAbs) are a novel category of drugs that are also changing the treatment paradigm of patients with DLBCL. They are engineered to bind to two different targets at the same time. To date, two BsAbs (glofitamab and epcoritamab) are approved as monotherapy in third-line treatment in DLBCL. Combination strategies with chemotherapy, immunotherapy, and ADCs are currently under investigation with encouraging results in first-line or subsequent lines of treatment. In the following review, we focus on the structure of BsAbs, the mechanism of action, clinical efficacy, and the mechanisms of resistance to BsAbs. Full article
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