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Precision Medicine in Critical Care Medicine: Novel Challenges and Advances
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Precision Medicine in Critical Care Medicine: Novel Challenges and Advances

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Medical Care".

Deadline for manuscript submissions: 25 January 2026 | Viewed by 11030

Special Issue Editor

Dr. Fernando Ramasco-Rueda

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Guest Editor
Department of Anaesthesiology and Surgical Intensive Care, Hospital Universitario de La Princesa, Diego de León 62, 28006 Madrid, Spain
Interests: hemodynamics; monitoring; infection; perioperative; high-risk patients; life support; multiple organ failure; biomarkers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Advances in precision medicine are redefining the management of critically ill and high-risk perioperative patients. In intensive care and perioperative settings, where time-sensitive and individualized decisions are crucial, the integration of personalized diagnostics and therapies holds the promise of significantly improving outcomes.

This Special Issue of the Journal of Personalized Medicine invites researchers and clinicians to contribute original research articles, narrative reviews, and systematic reviews focused on the application of precision medicine in critical care and perioperative intensive medicine. We aim to provide a platform for innovative studies addressing the challenges and opportunities of tailoring interventions based on individual patient profiles, biomarkers, dynamic monitoring, and advanced support therapies.

We welcome contributions that explore topics such as personalized hemodynamic management, infection control strategies, perioperative optimization of high-risk patients, life-support technologies, multiple organ dysfunction management, and the role of biomarkers in guiding therapy. Papers incorporating artificial intelligence, machine learning, big data analytics, and omics approaches in critical care are particularly encouraged.

Our goal is to gather cutting-edge research that not only advances scientific knowledge but also fosters the clinical translation of precision medicine strategies to improve the care of the most vulnerable patients.

We look forward to receiving your valuable contributions.

Dr. Fernando Ramasco-Rueda
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • critical care medicine
  • intensive care unit (icu)
  • perioperative medicine
  • precision medicine
  • personalized therapy
  • hemodynamic monitoring
  • biomarkers
  • high-risk patients
  • organ support
  • artificial intelligence in critical care
  • sepsis
  • septic shock

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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13 pages, 441 KB  
Article
Frailty as an Independent Predictor of Mortality in Patients with Sepsis
by Alejandro Interián, Fernando Ramasco, Angels Figuerola and Rosa Méndez
J. Pers. Med. 2025, 15(9), 398; https://doi.org/10.3390/jpm15090398 - 26 Aug 2025
Viewed by 687
Abstract
Objectives: Personalized sepsis care requires understanding how pre-existing health status can influence outcomes. The aim of this study is to evaluate its impact on in-hospital and 12-month mortality in patients with sepsis, taking into account age, comorbidities, the Charlson Comorbidity Index, frailty, [...] Read more.
Objectives: Personalized sepsis care requires understanding how pre-existing health status can influence outcomes. The aim of this study is to evaluate its impact on in-hospital and 12-month mortality in patients with sepsis, taking into account age, comorbidities, the Charlson Comorbidity Index, frailty, anemia, and the Sequential Organ Failure Score Assessment (SOFA) in the first 24 h. Methods: An observational and retrospective study was conducted using data from the Sepsis Code program at the Hospital Universitario de La Princesa. The relationship between risk factors and mortality, as well as Intensive Care Unit (ICU) admission, was analyzed for the period 2016–2018 using bivariate and multivariate logistic regression. Results: A total of 547 patients were included. In the multivariate analysis, the risk factors independently associated with mortality were Rockwood Clinical Frailty Scale ≥ 5 (OR 2.45, p < 0.05); SOFA ≥ 4 (OR 2.13, p < 0.05); age (OR 1.98, p < 0.05); anemia (OR 1.85, p < 0.05); and specific comorbidities such as ischemic heart disease (OR 2.34, p < 0.05), severe liver disease (OR 3.62, p < 0.05), and metastatic cancer (OR 3.14, p < 0.05). Patients who were frail, had dementia, or heart failure were less likely to be admitted to the ICU. Conclusions: Frailty, comorbidities, age, and anemia are associated with outcomes in patients with sepsis and could be incorporated into mortality prediction models to guide tailored treatment strategies. Full article
(This article belongs to the Special Issue Precision Medicine in Critical Care Medicine: Novel Challenges and Advances)
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Review

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18 pages, 1898 KB  
Review
Point of View: A Holistic Four-Interface Conceptual Model for Personalizing Shock Resuscitation
by Philippe Rola, Eduardo Kattan, Matthew T. Siuba, Korbin Haycock, Sara Crager, Rory Spiegel, Max Hockstein, Vimal Bhardwaj, Ashley Miller, Jon-Emile Kenny, Gustavo A. Ospina-Tascón and Glenn Hernandez
J. Pers. Med. 2025, 15(5), 207; https://doi.org/10.3390/jpm15050207 - 20 May 2025
Cited by 1 | Viewed by 9927
Abstract
The resuscitation of a patient in shock is a highly complex endeavor that should go beyond normalizing mean arterial pressure and protocolized fluid loading. We propose a holistic, four-interface conceptual model of shock that we believe can benefit both clinicians at the bedside [...] Read more.
The resuscitation of a patient in shock is a highly complex endeavor that should go beyond normalizing mean arterial pressure and protocolized fluid loading. We propose a holistic, four-interface conceptual model of shock that we believe can benefit both clinicians at the bedside and researchers. The four circulatory interfaces whose uncoupling results in shock are as follows: the left ventricle to arterial, the arterial to capillary, the capillary to venular, and finally the right ventricle to pulmonary artery. We review the pathophysiology and clinical consequences behind the uncoupling of these interfaces, as well as how to assess them, and propose a strategy for approaching a patient in shock. Bedside assessment of shock may include these critical interfaces in order to avoid hemodynamic incoherence and to focus on microcirculatory restoration rather than simply mean arterial pressure. The purpose of this model is to serve as a mental model for learners as well as a framework for further resuscitation research that incorporates these concepts. Full article
(This article belongs to the Special Issue Precision Medicine in Critical Care Medicine: Novel Challenges and Advances)
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