Pathogenesis and Personalized Treatment of Respiratory Diseases

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Mechanisms of Diseases".

Deadline for manuscript submissions: 10 March 2025 | Viewed by 609

Special Issue Editors


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Guest Editor
1. Faculty of Nursing, University of Thessaly, 41500 Larissa, Greece
2. Respiratory Medicine Department, Faculty of Medicine, University of Thessaly, 41110 Larissa, Greece
Interests: human pathophysiology; clinical and medical research; medical education
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Respiratory Medicine, Faculty of Medicine, University of Thessaly, 41110 Larissa, Greece
Interests: respiratory medicine; physiology; epidemiology; airway diseases; pleural pathophysiology; cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The Special Issue entitled "Pathogenesis and Personalized Treatment of Respiratory Diseases" provides an in-depth analysis of the biological and environmental contributors to respiratory diseases. By investigating the complex interplay of genetic factors, immune responses, and external influences such as air quality and lifestyle habits, this issue sheds light on the mechanisms driving diseases like asthma, chronic obstructive pulmonary disease (COPD), and pulmonary fibrosis. The articles offer a detailed examination of how pathogens, inflammatory processes, and cellular dysfunction pave the way for these conditions, enhancing our understanding of disease onset and progression. Advancements in diagnostic technologies are crucial for the early detection and management of respiratory diseases, and this Special Issue highlights significant innovations in this field. Personalization of treatment is a central theme of this Special Issue, reflecting a shift towards customized healthcare solutions that account for individual differences in genetics, environment, and lifestyle. It discusses the development and application of personalized medicine in respiratory care, including pharmacogenomics, which tailors drug therapies based on genetic makeup, and the use of biologics to target specific pathways involved in disease processes. The issue also examines the potential of novel therapeutic strategies such as gene therapy and regenerative medicine, offering insights into their current status and future possibilities in treating respiratory diseases. The compilation includes a series of case studies and reviews of clinical trials that illustrate the practical applications and challenges of personalized treatments in respiratory medicine. These real-world examples provide evidence of the benefits and limitations of customized therapies, highlighting patient outcomes, adherence issues, and the economic implications of personalized care. By presenting these case studies, this issue not only showcases successful implementations but also discusses the barriers to the widespread adoption of personalized treatment approaches in clinical settings. Looking forward, this Special Issue delves into the future of research and treatment in respiratory diseases, emphasizing the role of emerging technologies and scientific advancements. It speculates on the potential impacts of artificial intelligence (AI), machine learning, and digital health technologies on disease management and patient care. Furthermore, it encourages publishing research into novel therapeutic targets and treatment modalities that could revolutionize the management of respiratory conditions.

Dr. Ourania S. Kotsiou
Prof. Dr. Konstantinos Gourgoulianis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • copd
  • asthma
  • bronchiectasis
  • small airways
  • biologics
  • epigenetics
  • metabolomics

Published Papers (1 paper)

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Research

11 pages, 1333 KiB  
Article
Proportions and Seasonal Patterns of Respiratory Viruses via Rapid Tests in Adults at a Greek Hospital (Oct. 2023–Mar. 2024)
by Eleni Rousogianni, Garyfallia Perlepe, Stylianos Boutlas, Georgia G. Rapti, Evdoxia Gouta, Eleni Mpaltopoulou, Giorgos Mpaltopoulos, Erasmia Rouka, Dimitrios Papagiannis and Konstantinos I. Gourgoulianis
J. Pers. Med. 2024, 14(8), 824; https://doi.org/10.3390/jpm14080824 - 3 Aug 2024
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Abstract
Background: Respiratory infections pose a major public health threat. The predominant viruses causing viral respiratory infections are influenza A and B (Flu-A, Flu-B), coronaviruses, respiratory syncytial virus (RSV), and adenovirus. This study aims to investigate the proportion of these cases via rapid antigen [...] Read more.
Background: Respiratory infections pose a major public health threat. The predominant viruses causing viral respiratory infections are influenza A and B (Flu-A, Flu-B), coronaviruses, respiratory syncytial virus (RSV), and adenovirus. This study aims to investigate the proportion of these cases via rapid antigen tests and assess seasonal patterns. Methods: Clinical samples were collected from symptomatic adults presenting to the Emergency and Respiratory Medicine Departments of the University Hospital of Larissa (UHL), Greece from 16 October 2023 to 31 March 2024. Nasal specimens were antigen-tested for Flu-A/B, SARS-CoV-2, RSV, and adenovirus. Results: The total sample of specimens collected was 1434, of which 739 (51.5%) were female and 695 were male (48.5%). The mean age of participants was 57 ± 5.5 years. Among the positive results, we recorded a proportion of 40.18% and 11.40% for influenza A and B, respectively, followed by 35.79% for SARS-CoV-2, 10.70% for RSV, and 1.93% for adenovirus. Conclusions: In Greece, surveillance systems in infection control are underutilized. Rapid tests via multiple antigens can quickly identify viral infections, making them a valuable tool with financial benefits for health systems. Early detection of respiratory infections helps allocate resources efficiently, ensures adequate staff and facilities are available, and improves patient care through refined clinical management. Full article
(This article belongs to the Special Issue Pathogenesis and Personalized Treatment of Respiratory Diseases)
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