Pharmacokinetics and Pharmacodynamics in Personalized Medicine
A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Pharmacogenetics".
Deadline for manuscript submissions: closed (10 January 2024) | Viewed by 3534
Special Issue Editor
Special Issue Information
Dear Colleagues,
With the development of medicine, personalized medicine is increasingly recognized by medical staffs, which can greatly aid the advancements of preventive care. The success of personalized medicine depends on accurate diagnostic tests with individual pharmacokinetic (PK) and pharmacodynamics (PD) characteristics. PK and PD are the two main principles determining the relationship between dose and response.
PK helps to determine the dose–response relationship in individual clinical efficacy and drug toxicity. In clinical therapy, drug plasma/serum/blood concentrations are usually detected to monitor drug PK characters, especially for some drugs with narrow therapeutic windows, and patients with liver and kidney insufficiency.
PD is used to measure the clinical outcomes. Due to individual differences, variations in the PD response become more profound.
PK/PD modelling is the discipline establishing quantitative links between PK and PD fundamental features.
New drugs and old drugs with narrow therapeutic windows and higher toxicities usually need PK, PD, and PK/PD studies. These old drugs include, but are not limit to antibiotics, immunosuppressants, cardiovascular drugs, and psychotropic drugs.
Dr. Lijun Zhang
Guest Editor
Manuscript Submission Information
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Keywords
- pharmacokinetics
- pharmacodynamics
- personalized medicine
- antibiotics
- immunosuppressant
- cardiovascular drugs
- psychotropic drugs
- therapeutic drug monitoring