Challenges and Opportunities in Personalized Management of Bone and Joint Infections
A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Clinical Medicine, Cell, and Organism Physiology".
Deadline for manuscript submissions: 31 May 2025 | Viewed by 1609
Special Issue Editor
2. Foisor Clinical Hospital of Orthopedics, Traumatology, and Osteoarticular TB, 021382 Bucharest, Romania
Interests: orthopedic implants biofilm-related infection; diagnosis and treatment of complex bone and joint infections; biofilms; prosthetic joint infections; septic arthritis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Prosthetic joint infections (PJIs) are biofilm-associated infections that occur in a small percentage of patients who have undergone joint replacement surgeries. While the incidence of PJIs is low (1-3%), the increasing frequency of arthroplasties has made it a significant public health issue. PJIs are difficult to manage due to the presence of biofilm, which hinders diagnostics and treatment. The eradication of PJIs requires a combination of surgery and antimicrobial therapy, with the added goal of relieving pain and maintaining joint function. However, not all patients achieve these outcomes.
The Special Issue titled "Challenges and Opportunities in Personalized Management of Bone and Joint Infections" provides novel insights into the prevention, diagnosis, and treatment strategies of bone and joint infections, with a particular focus on PJIs. This Special Issue emphasizes the need for a multidisciplinary approach to manage PJIs and highlights the challenges in accurate diagnosis and effective treatment.
This Special Issue welcomes key papers that address various aspects of PJIs, including microbiological diagnosis, personalized therapies, and prevention strategies. It explores novel approaches in diagnosing PJIs, including the use of state-of-the-art diagnostic techniques like NGS and MALDI-TOF MS, and their role in choosing the best therapeutic strategies, especially in complex cases.
This Special Issue also delves into non-common anti-infective agents like bacteriophages or lysins that target pathogens specifically and have antibiofilm activities.
This Special Issue emphasizes personalized treatment strategies based on the patient's specific condition and clinical health data, with a potential role for machine learning in identifying high-risk patients. It also addresses the economic and health consequences of managing chronic PJIs, including the costs associated with reimplantation and the high rate of subsequent new infections.
Also, papers on the diagnostics and management of septic arthritis in native joints are welcome.
Overall, this Special Issue serves as a comprehensive platform for delivering novel insights into the prevention, diagnosis, and treatment strategies of bone and joint infections, contributing significantly to the field.
We welcome both reviews and original articles, but submissions are not limited to these types of manuscripts. By sharing our knowledge and experience, we can work towards a better understanding and management of bone and joint infections.
I look forward to receiving your submissions.
Dr. Rareş Mircea Bîrluţiu
Guest Editor
Manuscript Submission Information
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Keywords
- bone and joint infections
- prosthetic joint infection
- arthroplasty infection
- definition of prosthetic joint infection
- prosthetic joint infection prevention
- diagnosis of prosthetic joint infection
- prosthetic joint infection management
- antimicrobial therapy of prosthetic joint infection
- diagnostics and management of septic arthritis in native joints
- future research directions for improved patient outcomes
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