Novel Insights in Diagnostics and Personalized Therapeutics in Obstetrics and Gynecology

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".

Deadline for manuscript submissions: 28 June 2026 | Viewed by 898

Special Issue Editors


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Guest Editor
1st Department of Obstetrics and Gynecology, General Hospital of Athens 'ALEXANDRA', National and Kapodistrian University of Athens, Vasilissis Sofias 80 Aven., 11528 Athens, Greece
Interests: fetal medicine; maternal medicine; high risk pregnancy

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Guest Editor
1st Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Alexandra Hospital, 11528 Athens, Greece
Interests: gynecologic oncology; meta-analysis; laparoscopic surgery; cohort studies; obstetric delivery; gynaecological surgery screening; fetal growth restriction; prenatal diagnosis; proteomics; reproductive medicine
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Gynecology, Athens Naval and Veterans Hospital, 11521 Athens, Greece
Interests: gynecological surgery; gynecology; reproductive surgery; gynecologic oncology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, several research groups have published their work on diagnostic markers, numerous diagnostic biochemical and biophysical indices, management strategies, and novel treatment modalities on several areas of Obstetrics and Gynecology. Obstetrics and Gynecology has been and remains a medical field that prioritizes and focuses on individualized care, and, as such, a more personalized approach is constantly sought after. The advancements in this field seem to have contributed to a number of changes in the daily clinical practice and have triggered a more in depth exploration of the undelying mechanisms of both benign and malignant gynecological conditions, as well as, a better understading and assessment of pregnancy complications. The theme of this Special Issue of Journal of Personalized Medicine is ‘Novel insights in Diagnostics and Personalized Therapeutics in Obstetrics and Gynecology’ and it is aimed on enriching the literature with novel insights on the diagnosis,management and treatment of  pregnancy complications and benigh and malignant gynecologic conditions.

This Special Issue is addressed and invites scientific projects dedicated but not limited to the following areas:

  • Novel markers and strategies on the diagnosis, management and treatment of adverse pregnancy outcomes such as Hypertensive Disorders of Pregnancy, Gestational Diabetes, Fetal Growth restriction, Obstetric Cholestasis, Preterm Labor and Birth, (Preterm) Premature Rupture of Membranes.
  • Novel insights on first, second and third trimester fetal ultrasound.
  • Advancements in the detection of fetal congenital anomalies and underlying genetic abnormalities.
  • Advancements in the area of minimal invasive endoscopic gynecologic surgery ( Robotic-, Laparoscopic-, Hysteroscopic-,VNOTES).
  • Diagnostic and Therapeutic advancements in different aspects of gynecologic oncology.

We are soliciting Original Research, Narrative Reviews, Systematic Reviews and Meta-analysis.

Dr. Ioakeim Sapantzoglou
Dr. Vasilios Pergialiotis
Dr. Dimitrios Papageorgiou
Guest Editors

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Keywords

  • pregnancy complications
  • adverse pregnancy outcomes
  • preeclampsia
  • preterm labor
  • gynecologic oncology
  • minimal invasive endoscopic surgery

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Published Papers (1 paper)

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Review

20 pages, 593 KB  
Review
The Effect of Fibrin Sealants on Tubal Reanastomosis: A Comprehensive Review of the Literature
by Dimitrios Papageorgiou, Vasilios Pergialiotis, Ioakeim Sapantzoglou, Eleni Sivylla Bikouvaraki, Nikolaos Salakos, Stylianos Kykalos and Konstantinos Kontzoglou
J. Pers. Med. 2026, 16(1), 12; https://doi.org/10.3390/jpm16010012 - 31 Dec 2025
Cited by 2 | Viewed by 590
Abstract
Background/Objectives: Female tubal factor infertility is a major clinical challenge. While surgical repair of the fallopian tubes remains the traditional standard, biological fibrin sealants have been proposed to reduce tissue trauma and improve reproductive outcomes. Methods: We conducted database searches of [...] Read more.
Background/Objectives: Female tubal factor infertility is a major clinical challenge. While surgical repair of the fallopian tubes remains the traditional standard, biological fibrin sealants have been proposed to reduce tissue trauma and improve reproductive outcomes. Methods: We conducted database searches of PubMed/MEDLINE, EMBASE and Google Scholar until 31 August 2025, using the keywords “tubal anastomosis”, “tubal reanastomosis,” “tubal reanastomosis”, “uterine horn anastomosis”, “fibrin glue”, “fibrin sealant”, “biological sealant”, “tissue adhesive”, “rabbit”, “rat” and “sterilization reversal.” Reference lists of retrieved articles have been examined to find studies which tested end-to-end tubal (or small-animal uterine horn) anastomosis through biological adhesives with or without additional components to evaluate patency success, fertility results and adhesion formation. Results: Thirteen studies met the inclusion criteria (eleven animal; two human). Rat and rabbit models demonstrated that fibrin sealants with intraluminal splints and one-to-two anchoring sutures produced results comparable to microsutures for patency (tubal patency rates of 75–100%) and pregnancy success (pregnancy rates of 60–83%) while reducing surgical time and decreasing peritubal adhesions. The success rates of the procedures depended on the anastomosis locations. Isthmic–isthmic anastomosis produced better results than ampullary repairs which tended to fail or develop stenosis. Fibrin sealant-only repairs without splinting were associated with lower patency (almost 60%) despite acceptable histologic healing. Human data showed similar pregnancy rates (intrauterine pregnancy in about 40–50% of women) and tubal patency but no consistent decrease in adhesions. Ectopic pregnancy rates ranged from 9 to 11%. Conclusions: Fibrin sealants are useful adjuncts to microsurgical tubal repair, but they should not replace the basic repair procedures. The effectiveness of this procedure is dependent on three critical factors: precise segment alignment, proper use of splints and stents, and selection of segments with comparable caliber. In a personalized-medicine framework, fibrin-assisted reanastomosis may offer a tailored option for selected women who desire natural pregnancy. Modern standardized research is required to define indications and analyze how the adaptation of fibrin sealants in minimally invasive procedures affect reproductive outcomes, ectopic pregnancy rates, and adhesion development. Full article
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