Personalized Diagnosis and Personalized Therapy in Chronic Upper Aerodigestive Tract Disorders

Dear Colleagues,

Upper aerodigestive tract (UADW) disorders are among the most frequent chronic diseases. The UADW is a single anatomic tract that performs three different functions, including phonation, swallowing, and breathing, of which the last two are life-sustaining functions. Laryngeal disorders such as chronic sinusitis and otitis are just a small part of the entire list of the UADW diseases that also includes laryngopharyngeal reflux. The crucial position of this anatomical tract makes its pathology the subject of interest of different specialists such as gastroenterologists, otorhinolaryngologists, phoniatricians, and pneumologists. It is known that UADW diseases have a clinical and socio-economic impact because of the high prevalence in paediatric and adult populations.

The rapid development of new techniques and methods in recent years has led to great advances in diagnostics and therapy of UADW diseases. Nevertheless, chronic UADW disorders affect millions of people worldwide, and the number is expected to rise considerably in future years. Chronic diseases are biologically complex and driven by multiple mechanisms. They are  heterogenous in symptoms and co-morbidities, as well as in the way they are diagnosed over the course of disease. Currently, the diagnosis relies on clinical symptoms, standard instrumental assessments, or patient parameters. However, tests are often limited, imprecise, and occur late in the disease’s progression (i.e., obstructive sleep apnoea syndrome (OSAS)). It is of paramount importance to improve patient outcomes with therapy. The aim of this Special Issue is to collect research that provides new methods for diagnosis, particularly for early diagnosis, or new targeting treatments for specific and earlier disease conditions.

Dr. Maria Raffaella Marchese
Guest Editor

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• upper aerodigestive tract
• swallowing
• voice
• rhinitis
• sinonasal diseases
• dysphonia
• tonsillitis
• peritonsillar abscess
• OSAS
• laryngopharyngeal reflux