Genetic Basis and Clinical Determinants of Inherited Heart Disease
A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Mechanisms of Diseases".
Deadline for manuscript submissions: closed (20 October 2021) | Viewed by 8083
Special Issue Editor
Special Issue Information
Individuals with inherited heart disease may exhibit strongly varying disease severity, even within the same family, ranging from being asymptomatic and difficult to recognize carriers to suffering sudden death and/or heart failure at a young age. This variability may stem from genetic factors (modifier genes) and/or clinical factors (comorbidities, lifestyle risk factors, drug use), and it poses a challenge to designing personalized disease management, including risk stratification and personalized treatment.
The aim of this Special Issue of the Journal of Personalized Medicine is to outline recent trends, updates, and progress on how genetic factors and/or clinical factors may impact disease severity in individuals with inherited heart disease.
After the discovery of the various types of inherited heart disease, a monogenic disease model was initially adopted. However, it was soon recognized that such a model could not account for the great variability in disease severity. Additional models were developed, including polygenic risk models and risk scores composed of both genetic and clinical factors. The development of these models has been boosted by the creation of large datasets in international consortia and the increasing availability of affordable methods for large-scale genetic studies.
Multidimensional research is needed and being conducted to resolve the complexity of inherited heart diseases, including genetic, molecular, and clinical studies.
We are inviting the submission of original articles and review articles to this Special Issue that cover the whole spectrum of management of inherited heart disease, covering genetic, molecular, and clinical studies.
Dr. Hanno L. Tan
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Inherited heart disease
- Cardiogenetics
- Inherited arrhythmia syndrome
- Long QT syndrome
- Brugada syndrome
- Cardiomyopathy
- Genetics
- Polygenic risk score
- Risk prediction
- Risk score
