Light, Radiology and Omics in Personalized Medicine: Towards Screening, Diagnostic and Treatment Applications in Clinical Practice

Dear Colleagues,

Contributions in the form of original articles, tutorials, systematic reviews, communications and well-designed case studies from researchers and clinicians working on light-based, radiology and/or omics technologies in personalized medicine, as well as those willing to offer experiences and perspectives about the integration of precision medicine technologies in clinical practice, are invited for this Special Issue.

There has been a growing interest in precision medicine based on monitoring diagnostic and prognostic biomarkers for a multitude of medical conditions. Numerous studies have reported that the utility of monitoring vital signs should be re-evaluated in subspecialty clinics, given that abnormal vital sign measurements may not be captured in time for the appropriate clinical intervention and can vary due to stress or anxiety about surgical procedures or upcoming tests. Currently, technological advances in personalized medicine have enabled not only individual vital signs to be monitored in real time and non-invasively, but also personalized metabolomics, proteomics, peptidomics, transcriptomics and genomics to be obtained. The data collected have brought an unprecedented development to digital health, telemedicine, individualized therapy, pharmacogenomics and omics-based non-drug-related health interventions. This development has been fostered by the implementation of preventive healthcare strategies involving screening programs based on newly identified biomarkers, and/or personalized drug delivery and precise treatment dosimetry.

The implementation of such strategies in clinical practice has been associated with regulatory policies concerning topics such as health insurance coverage and reimbursement. Such implementation has been hindered by missing data and the lack of consistency across coverage policies of different insurers. Thorough implementation of personalized medicine in clinical practice is dependent on sufficient investment in novel technologies for high-throughput screening, biomarker identification, automated dosimetry adjustment, the manufacture of minimally invasive implantables, miniaturized and cost-effective devices, and clinical trials to evaluate such technologies. Finally, timely and consistent research is needed to adjust personalized medicine not only to the context of the individual, but also to temporal effects across populations including potential physiological effects of COVID-19 and vaccines, which can lead to different considerations across medical specialties and subspecialties.

This Special Issue welcomes original articles, tutorials, systematic reviews, communications and well-designed case studies on the development, evaluation and implementation of light-based, radiology and/or omics technologies in personalized medicine and their associated resources (including software, graphical user interfaces and web applications). We also welcome reports of empirical work presenting experiences and perspectives about the integration of precision medicine in clinical practice. We will consider in vitro, ex vivo and in vivo experiments for the screening, diagnostics and treatment of medical conditions. Submissions are open to any medical specialty. Topics of interest include (but are not restricted to) personalized medicine in:

• Diagnostic and prognostic biomarker identification;
• Precision medicine in clinical practice;
• Opportunities enabled by digital health and telemedicine;
• Statistics including biostatistics and artificial intelligence/machine learning;
• Preventive healthcare strategies;
• Organ transplantation;
• Chronic and autoimmune diseases;
• Cancer and oncology;
• Surgery and surgical procedures;
• Critical care/intensive care medicine;
• Public health;
• Pediatrics and geriatrics;
• Oral science, dentistry and healthcare;
• Eating disorders and nutrition;
• Gastrointestinal diseases;
• Cardiovascular diseases;
• Management of COVID-19;
• Neurological conditions including Alzheimer's, Parkinson's disease, epilepsy, migraines, multiple sclerosis, stroke and palsy;
• Inflammation and infection;
• Orthopedics, rheumatology and traumatology;
• Ophthalmology and eye diseases;
• Lung and respiratory diseases;
• Bioethics, reimbursement, regulatory and precision medicine ecosystem;
• Nanomedicine;
• Drug delivery, uptake, kinetics, dosimetry and metabolism;
• Microfluidics, implantables, wearables and mobile healthcare;
• Phototherapy and photodynamic therapy;
• Spectroscopy, imaging, tomography or topography;
• Virtual, augmented and mixed reality;
• Metabolomics, proteomics, peptidomics, transcriptomics and genomics;
• Light, ultrasound and electromagnetic radiation (ionizing or non-ionizing) technologies.

Dr. Marcelo Saito Nogueira

Dr. Chris. Kiang Wei Kho

Guest Editors

Dr. Marcelo Saito Nogueira
Prof. Dr. Kiang Wei Kho
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.