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Precision Medicine in Neurosurgery
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Precision Medicine in Neurosurgery

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Clinical Medicine, Cell, and Organism Physiology".

Deadline for manuscript submissions: closed (25 September 2024) | Viewed by 2079

Special Issue Editors

Dr. Filippo Maria Polli

E-Mail Website
Guest Editor
Department of Neurosurgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
Interests: spine surgery; spinal cord tumors; neuro-oncology; neurotraumatology; hydrocephalus; neuro-navigation; clinical informatics
Dr. Nicola Montano

E-Mail Website
Guest Editor
Functional Neurosurgery Operative Unit, Gemelli University Hospital, Rome, Italy
Interests: neuro-oncology; spine surgery; functional neurosurgery; neurovascular conflicts; traumatic brain injury; hydrocephalus
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Precision medicine is an innovative approach for the prevention and treatment of diseases, which has the aim of identifying a tailored treatment for each patient at the right time. It uses different methodologies, such as big data collection, the various omics and pharmaco-omics, artificial intelligence, and the study of social and environmental factors. Furthermore, in precision medicine, all these data are integrated with preventive and population medicine.

Given the potential dramatic impact of neurosurgical diseases and treatments on patient quality of life and survival, neurosurgery has always been at the frontier of surgical research.

The personalized approach through precision medicine methods may significantly impact on different neurosurgical fields. For example, the integration of molecular information in brain tumor diagnosis and treatment and the study of genetic and biochemical factors in movement disorders, hydrocephalus, chronic pain, spinal degenerative and tumoral pathologies could significantly affect our understanding of the pathophysiology of diseases and improve the response to different neurosurgical treatments. Moreover, cutting-edge technologies and novel surgical instrumentation allow neurological surgeons to deliver effective treatments together with minimally invasive surgical approaches.

The aim of this Special Issue of the Journal of Precision Medicine is to collect outstanding original articles, reviews and communications highlighting innovative and personalized approaches to the diagnosis and surgical treatment of neurosurgical diseases.

Dr. Filippo Maria Polli
Dr. Nicola Montano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Keywords

  • neurosurgery
  • surgical techniques
  • spine surgery
  • neuro-oncology
  • neurotraumatology
  • functional neurosurgery
  • traumatic brain injury
  • spinal cord
  • neuro-navigation
  • neuroimaging

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Published Papers (2 papers)

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Research

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9 pages, 230 KiB  
Article
The Role of Psychosomatic Traits in Tailored Workup for Anterior Cervical Discectomy and Fusion—A Case Series
by Marco Battistelli, Edoardo Mazzucchi, Mario Muselli, Filippo Maria Polli, Gianluca Galieri, Paola Bazzu, Fabrizio Pignotti, Alessandro Olivi, Giovanni Sabatino and Giuseppe La Rocca
J. Pers. Med. 2024, 14(5), 454; https://doi.org/10.3390/jpm14050454 - 25 Apr 2024
Cited by 1 | Viewed by 1243
Abstract
Study design: Prospective study. Objective: To evaluate the influence of preoperatively assessed psychosomatic traits on postoperative pain, disability, and quality of life outcomes. Summary of background data: Anterior cervical discectomy and fusion (ACDF) is a widely employed surgical procedure for treating cervical spondylosis. [...] Read more.
Study design: Prospective study. Objective: To evaluate the influence of preoperatively assessed psychosomatic traits on postoperative pain, disability, and quality of life outcomes. Summary of background data: Anterior cervical discectomy and fusion (ACDF) is a widely employed surgical procedure for treating cervical spondylosis. Despite its effectiveness, various studies have reported non-success rates in terms of alleviating disability and pain. Psychological factors have become increasingly recognized as critical determinants of surgical outcomes in various medical disciplines. The full extent of their impact within the context of ACDF remains insufficiently explored. This case series aims to assess the influence of preoperative psychological profiling on long-term pain, disability and quality of life outcomes. Methods: We conducted a prospective cohort study of prospectively collected data from 76 consecutive patients who underwent ACDF with PEEK inter-fixed cages from July 2019 to November 2021. The preoperative psychological traits were assessed using the Symptom Checklist 90 (SCL-90) questionnaire. The Oswestry Disability Index (ODI), Visual Analogue Scale (VAS), Neck Disability index (NDI), EuroQol-5D (EQ-5D), and Short Form-36 (SF-36) were collected preoperatively, one month postoperatively, and at least one year after the surgical procedure. Results: The correlation analyses revealed associations between psychosomatic traits and multiple preoperative and postoperative outcome measures. The univariate analyses and linear regression analyses demonstrated the influence of the Global Severity Index (GSI) over the final follow-up scores for the ODI, VAS, NDI, EQ-5D, and SF-36. The GSI consistently exhibited a stronger correlation with the final follow-up pain, disability, and quality of life outcomes with respect to the correspondent preoperative values. Conclusion: This study highlights the importance of psychosomatic traits as predictive factors for ACDF outcomes and emphasizes their relevance in preoperative assessment for informing patients about realistic expectations. The findings underscore the need to consider psychological profiles in the preoperative workup, opening avenues for research into medications and psychological therapies. Recognizing the influence of psychosocial elements informs treatment strategies, fostering tailored surgical approaches and patient care. Full article
(This article belongs to the Special Issue Precision Medicine in Neurosurgery)

Other

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11 pages, 4090 KiB  
Systematic Review
Clinical Implication of Brain Metastases En-Bloc Resection: Surgical Technique Description and Literature Review
by Roberto Altieri, Sergio Corvino, Giuseppe La Rocca, Fabio Cofano, Antonio Melcarne, Diego Garbossa and Manlio Barbarisi
J. Pers. Med. 2024, 14(11), 1110; https://doi.org/10.3390/jpm14111110 - 19 Nov 2024
Viewed by 335
Abstract
Background: The role of brain metastases (BM) surgery is of paramount importance for patients’ progression-free and overall survival. “En-bloc” and “piecemeal” resection represent the main surgical techniques. Although en-bloc resection remains the best surgical option, it is not widely adopted or feasible as [...] Read more.
Background: The role of brain metastases (BM) surgery is of paramount importance for patients’ progression-free and overall survival. “En-bloc” and “piecemeal” resection represent the main surgical techniques. Although en-bloc resection remains the best surgical option, it is not widely adopted or feasible as the first choice. We describe our point of view about the en-bloc surgical technique with an illustrative case and discuss its indications with pros and cons through a comprehensive literature review. Materials and methods: A Medline search up to December 2023 in the Embase and PubMed online electronic databases was made and PRISMA statement was followed. An illustrative case of “en-bloc” resection from our surgical series was also added as a technical note. Results: We describe tips and tricks of our surgical technique and added a surgical video from our series. The literature review disclosed 19 studies. Resulting data suggested that “en-bloc” resection, when feasible, provides lesser risk of leptomeningeal dissemination, local recurrence rates, intraoperative bleeding occurrence and perioperative complications; in addition, it preserves the normal anatomy. Conclusions: En-bloc resection is the gold standard technique for surgical treatment of brain metastases especially for patients with superficial lesions that are small in size and far from eloquent areas. Full article
(This article belongs to the Special Issue Precision Medicine in Neurosurgery)
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