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Special Issues
Clinical and Experimental Surgery in Personalized Molecular Medicine
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Clinical and Experimental Surgery in Personalized Molecular Medicine

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Clinical Medicine, Cell, and Organism Physiology".

Deadline for manuscript submissions: 15 July 2025 | Viewed by 1645

Special Issue Editors

Dr. Apostolos E. Papalois

E-Mail Website
Guest Editor
2nd Department of Surgery, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
Interests: new molecule development; pre-clinical studies; translational research; new technologies in surgery; education and simulation; leadership in research
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Manousos M. Konstadoulakis

E-Mail Website
Guest Editor
Director 2nd Department of Surgery, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
Interests: surgical oncology; laparoscopic surgery; Gastrointestinal surgery

Special Issue Information

Dear Colleagues,

Surgical research can encompass a variety of different fields, like the evaluation of new technologies, biomaterials, a new molecule with pharmaceutical activity, predictive interventions, and prognostic interventions, as well as combinations of all the described methods.

This new approach can be implemented at an experimental as well as a clinical level.

Under the modern prism of personalized molecular medicine and the future applications in clinical practice, surgical research opens a new window on innovation and the implementation of these modern methods for the benefit of the patients.

This Special Issue focuses on the publication of both experimental and clinical surgical research papers, in combination with personalized molecular methods, aiming at promoting scientific knowledge and multidisciplinary approaches in future medical therapies.

Dr. Apostolos E. Papalois
Prof. Dr. Manousos M. Konstadoulakis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • personalized molecular medicine
  • clinical practice
  • surgical research
  • surgical oncology
  • multidisciplinary approaches

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

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Research

12 pages, 1624 KiB  
Article
Expression of Tissue Remodeling- and Inflammation-Related Factors During the Wound-Healing Process in Humans
by Dimitrios Vardakostas, Athanasios Moustogiannis, Zoe Garoufalia, Elli Karatza, Anastassios Philippou, Gregory Kouraklis, Michael Koutsilieris and Dimitrios Mantas
J. Pers. Med. 2025, 15(1), 14; https://doi.org/10.3390/jpm15010014 - 2 Jan 2025
Viewed by 645
Abstract
Background/Objectives: There is a growing interest in the research of wound healing mechanisms worldwide. Particular attention has been paid to the expression of tissue remodeling- and inflammation-related factors. Herein, we investigate the expression patterns of TGF-β1, IL-6, TNF-a, uPA, uPA receptors, MMP-2, [...] Read more.
Background/Objectives: There is a growing interest in the research of wound healing mechanisms worldwide. Particular attention has been paid to the expression of tissue remodeling- and inflammation-related factors. Herein, we investigate the expression patterns of TGF-β1, IL-6, TNF-a, uPA, uPA receptors, MMP-2, and MMP-9 through the four phases of the normal wound-healing process in humans. Methods: Twenty-two individuals presenting with a first episode of pilonidal sinus underwent surgical excision and the wound was left to heal by secondary intention. Sequential biopsies were collected on day 0 (operation), day 2 (inflammatory phase), day 9 (proliferative phase), and day 14 (tissue remodeling phase). The expression levels of the proteins were evaluated using reverse transcription–quantitative PCR. Statistical analyses were performed using GraphPad Prism software. One-way analysis of variance (ANOVA) with Dunn’s Multiple Comparison post hoc test was used. Results: The results showed statistically significant differences in the expressions of the factors during wound healing (p < 0.05). TGF-b1 increased on days 2 and 9. TNF-a increased on day 2 and then decreased on day 9. Il-6 was increased on day 2 and decreased on days 9 and 14. uPa mRNA increased up to day 9 but its receptor exhibited high expression throughout the observation time. Finally, MMP-2 mRNA expression increased on day 2 and declined on days 9 and 14, while MMP-9 was highly expressed until the 14th postoperative day. Conclusions: Each factor investigated in this study has an important and distinct role in the normal wound repair procedure. Further investigation is required to evaluate the tissue-specific regulation of these factors and their potential use as therapeutic targets or prognostic biomarkers in wound healing. Full article
(This article belongs to the Special Issue Clinical and Experimental Surgery in Personalized Molecular Medicine)
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10 pages, 987 KiB  
Article
Cerebral Aneurysms and Arteriovenous Malformation: Preliminary Experience with the Use of Near-Infrared Fluorescence Imaging Applied to Endoscopy
by Denis Aiudi, Alessio Iacoangeli, Andrea Mattioli, Alessio Raggi, Mauro Dobran, Gabriele Polonara, Riccardo Gigli, Maurizio Iacoangeli and Maurizio Gladi
J. Pers. Med. 2024, 14(12), 1117; https://doi.org/10.3390/jpm14121117 - 22 Nov 2024
Viewed by 546
Abstract
Background/Objectives: Indocyanine green video angiography, integrated into the operative microscope, is frequently used in cerebrovascular surgery. This technology is often preferred, for cost or availability, to Doppler or intraoperative DSA (digital subtraction angiography). With the same assumption it was possible, in our preliminary [...] Read more.
Background/Objectives: Indocyanine green video angiography, integrated into the operative microscope, is frequently used in cerebrovascular surgery. This technology is often preferred, for cost or availability, to Doppler or intraoperative DSA (digital subtraction angiography). With the same assumption it was possible, in our preliminary experience, to partially vicariate the aforementioned devices using the SPY mode of the Stryker endoscope; it allowed the visualization of fluorescence in high definition. Methods: A retrospective analysis was conducted on a series of five patients suffering from cerebral aneurysm or AVM (arteriovenous malformation) who underwent, during the last year, surgical treatment with the aid of the microscope supported by the Stryker endoscope in the SPY mode for the visualization of the fluorescence emitted by indocyanine green. Results: All aneurysms were completely excluded from the cerebrovascular circulation in the absence of residues in the collar and occlusion of adjacent vessels; the complete removal of the nidus in all the AVMs was achieved with no residues. Conclusions: The intraoperative use of indocyanine green was a safe, rapid, and effective technique within a preliminary case study of “regular—not giant” aneurysms and superficially located AVM. The endoscopic technique in the SPY mode has allowed to partially vicariate the use of Doppler, intraoperative angiography, and integrated microscope video angiography. For these purposes, we propose, in selected cases, the support of the endoscope in the SPY mode during the microsurgical procedure in order to visualize the green fluorescence of indocyanine. Full article
(This article belongs to the Special Issue Clinical and Experimental Surgery in Personalized Molecular Medicine)
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