Atherosclerosis: From Pathogenesis to Treatment and Outcomes

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Mechanisms of Diseases".

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 3834

Special Issue Editor


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Guest Editor
1. Laboratory of Molecular Genetics, National Medical Research Center for Therapy and Preventive Medicine, Ministry of Health of the Russian Federation, Moscow, Russia
2. Department of General and Medical Genetics, Pirogov Russian National Research Medical University, Moscow, Russia
Interests: cardiology; atherosclerosis; familial hypercholesterolemia; noncompact cardiomyopathy; genetic testing

Special Issue Information

Dear Colleagues,

Research in the field of atherosclerosis has been actively carried out for over 150 years. However, there are currently black holes in our knowledge of the disease. This Special Issue of the Journal of Personalized Medicine aims to show some of the latest findings in the field of atherosclerosis. We invite researchers in this field to submit original research and review articles, including studies on the discovery of novel biomarkers (including genetic and epigenetic biomarkers) and new targets for therapeutic interventions; assessment of the treatment efficacy and outcomes in patients with different genetic forms of monogenic dyslipidemia; the contribution of the microbiome to disease development. Scientific advances in the field of atherosclerosis will provide the path towards developing personalized medicine.

Dr. Alexey N. Meshkov
Guest Editor

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Keywords

  • atherosclerosis
  • biomarkers
  • molecular genetic
  • monogenic dyslipidemias
  • epigenetics
  • microbiome
  • treatment
  • outcomes

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Published Papers (1 paper)

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Research

11 pages, 13196 KiB  
Article
Macrophages of the “Heart-Kidney” Axis: Their Dynamics and Correlations with Clinical Data and Outcomes in Patients with Myocardial Infarction
by Maria Kercheva, Vyacheslav Ryabov, Aleksandra Gombozhapova, Maria Rebenkova and Julia Kzhyshkowska
J. Pers. Med. 2022, 12(2), 127; https://doi.org/10.3390/jpm12020127 - 18 Jan 2022
Cited by 6 | Viewed by 3533
Abstract
Changes in the macrophage infiltration of kidneys in rodents under ischemic conditions may affect cardiac macrophages and lead to development of adaptive cardiac remodeling. The aim of our study was to translate experimental findings into clinically relevant applications and assess the features of [...] Read more.
Changes in the macrophage infiltration of kidneys in rodents under ischemic conditions may affect cardiac macrophages and lead to development of adaptive cardiac remodeling. The aim of our study was to translate experimental findings into clinically relevant applications and assess the features of macrophage infiltration of the kidney and its correlations with changes in macrophage infiltration of the myocardium and with clinical data in patients who experienced a fatal myocardial infarction (MI). We examined fragments of both organs taken from patients (n = 30) who suffered from fatal MI. Macrophage infiltration was assessed by immunohistochemistry. Macrophage infiltration of the kidneys in patients with fatal MI is heterogeneous. The early period of MI was shown to be characterized by the prevalence of CD163+ and CD68+ cells, and in the long-term period by only CD163+ cells. However, only the level of CD206+ cells in the kidneys showed the dynamics representing the late MI period. Its decrease accompanied increase in the numbers of cardiac CD68+, CD163+, CD206+, and stabilin-1+ cells in the infarct area. Kidney CD206+ cells had more correlations with cardiac macrophages than other cells, and the presence of these cells also correlated with impairment of renal function and early death. Full article
(This article belongs to the Special Issue Atherosclerosis: From Pathogenesis to Treatment and Outcomes)
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