Personalized Treatment and Hereditary Causes of Nephrotic Syndrome
A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Mechanisms of Diseases".
Deadline for manuscript submissions: closed (10 July 2021) | Viewed by 6271
Special Issue Editor
Interests: kidney; renal genomics; human glomerular disease modeling; focal segmental glomerulosclerosis (FSGS); clinical nephrology; health care
Special Issue Information
Dear Colleagues,
Nephrotic Syndrome (NS) is a major cause of chronic and end-stage kidney disease worldwide. While the mechanisms of NS are not fully understood, advances in renal genetics over the past three decades have highlighted glomerular visceral epithelial cells (i.e., podocytes) as the principal cell type affected in disease pathogenesis. It is now clear that podocyte injury or loss is a necessary precursor of glomerular dysfunction in NS and studies of familial forms of the disease have identified a variety of molecular targets involved in podocyte actin cytoskeletal dynamics, slit diaphragm and basement membrane assembly, calcium transport, mitochondrial energetics, nuclear transport and gene expression and cell cycle regulation. Despite these discoveries, few have translated into potential therapies for NS. In this Special Issue of the Journal of Personalized Medicine entitled “Personalized Treatment and Hereditary Causes of Nephrotic Syndrome,” we will highlight:
- Emerging technologies for characterizing podocyte biology
- Novel insights into the mechanisms of podocyte injury
- Novel model systems for modeling podocyte injury (i.e., ex vivo or in vivo)
- Novel methods or approaches for high throughput screening of candidate compounds for podocytopathies
- Exploration of podocyte transcriptomics and proteomics in health and disease to identify novel therapeutic targets
We will be accepting submissions in these areas to assemble a Special Issue focused on the translation of findings in renal genetics into rational therapies for nephrotic syndrome.
Dr. Gentzon Hall
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- nephrotic syndrome (NS)
- renal genetics
- podocyte
- biology
- mechanisms of podocyte injury
- transcriptomics and proteomics
- personalized therapy
