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Journal of Personalized Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Personalized Medicine in Hematologic Malignancies: Advances and Prospects

edited by Khalil Saleh

submission deadline 30 Nov 2026 | Viewed by 233 | Submission Open

Keywords: CAR T-cells; bispecific antibodies; antibody– drug conjugates; bispecific T-cell engagers; artificial intelligence; mechanisms of resistance; biomarkers

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Molecular and Technological Horizons in Ophthalmology: Precision Medicine from Artificial Intelligence to Optogenetic Vision Restoration

edited by

Caterina Gagliano

José Fernando Maya-Vetencourt

and

Dario Rusciano

submission deadline 30 Nov 2026 | Viewed by 194 | Submission Open

Keywords: ophthalmology; precision medicine; biomolecules; artificial intelligence; optogenetics; retinal degeneration; gene therapy; neuroprosthetics; nanocarriers; molecular diagnostics; vision restoration; oculomics

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Application of Medical Informatics and Knowledge-Based Ecosystem Management in Disease Diagnosis

edited by

Bernd Blobel

submission deadline 30 Nov 2026 | Viewed by 162 | Submission Open

Keywords: medical informatics; knowledge-based systems; disease diagnosis; personalized medicine; clinical decision support systems; artificial intelligence; data integration; knowledge mapping

(This special issue belongs to the Section Diagnostics in Personalized Medicine)

Management of Cardiac Arrhythmias: Towards Personalized Management

edited by

Dimitris L. Tsiachris

submission deadline 30 Nov 2026 | Viewed by 147 | Submission Open

Keywords: atrial fibrillation; ventricular arrhythmias; antiarrhythmic drugs; catheter ablation; anticoagulants; risk stratification; stroke prevention; energy sources

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Diagnostic Pathology: Current Status and Future Prospects

edited by

Pietro Tralongo

and

Guido Fadda

submission deadline 30 Nov 2026 | Viewed by 142 | Submission Open

Keywords: diagnostic pathology; personalized medicine; molecular pathology; digital pathology; artificial intelligence in pathology; biomarkers; histopathology; cytopathology; hematopathology; precision diagnostics; translational pathology; predictive and prognostic markers

(This special issue belongs to the Section Diagnostics in Personalized Medicine)

Advancing Spine Surgery: Innovations in Personalized Medicine

edited by Mitchell K. Ng

submission deadline 30 Nov 2026 | Viewed by 140 | Submission Open

Keywords: personalized spine surgery; precision medicine; artificial intelligence; spine innovations; endoscopic spine surgery; degenerative spinal disorders

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Liquid Biopsy: Basic Research and Clinical Utility

edited by

Jens Claus Hahne

submission deadline 30 Nov 2026 | Viewed by 135 | Submission Open

Keywords: liquid biopsy; circulating tumour cells (CTCs); circulating tummour DNA (ctDNA); cell free DNA (cfDNA); non-coding RNAs; protein biomarker; personalised medicine

(This special issue belongs to the Section Precision Oncology)

New Updates and Challenges in Personalized Orthopaedics

edited by Stephen M. Mcdonnell and Rahul Bhattacharyya

submission deadline 30 Nov 2026 | Viewed by 134 | Submission Open

Keywords: knee arthroscopy; knee replacement; partial knee replacement (sometimes called knee resurfacing); revision knee replacement; ACL reconstruction; hip replacement surgery; hip arthroscopy; knee replacement; knee arthroscopy

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Current Trends and Future Challenges in Precision Neuroimaging

edited by Chiara Gaudino and

Stefania Elena Navone

submission deadline 30 Nov 2026 | Viewed by 128 | Submission Open

Keywords: neuro-oncology; neurodegenerative disorders; ischemic and hemorrhagic stroke; head and neck pathologies

(This special issue belongs to the Section Diagnostics in Personalized Medicine)

Wearable Sensors, Machine Learning and Large Language Models for Personalized and Precision Healthcare

edited by

Iqram Hussain

submission deadline 30 Nov 2026 | Viewed by 89 | Submission Open

Keywords: wearable sensors; digital health; personalized healthcare; precision medicine; machine learning; deep learning; large language models; generative AI; artificial intelligence in healthcare; wearable signal processing (EEG; ECG; EMG; PPG; IMU); remote patient monitoring; flexible and stretchable sensors; Internet of things (IoT); smart healthcare systems; activity recognition; sleep medicine; data privacy and security; energy-efficient sensing; sustainability; digital twin; smart cities

(This special issue belongs to the Section Personalized Medical Care)

Personalized Approaches in Bladder Cancer Treatment: A Clinical and Translational Research Perspective

edited by

Vladimir Bilim

submission deadline 3 Dec 2026 | 1 articles | Viewed by 1087 | Submission Open

Keywords: bladder cancer (BC); systemic therapy; tailored therapy; immune checkpoint inhibitors; antibody– drug conjugates (ADCs); molecular targeted therapy

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Medicine in Endometriosis

edited by Christine Bekos

submission deadline 10 Dec 2026 | 3 articles | Viewed by 3049 | Submission Open

Keywords: microbiome; epigenetics; fatigue; laparoscopic surgery; lifestyle changes; endometriosis

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Diagnosis and Treatment of Digestive System Disorders

edited by Gengqing Song

submission deadline 10 Dec 2026 | 1 articles | Viewed by 2753 | Submission Open

Keywords: personalized medicine; gastrointestinal disorders; precision diagnostics; functional GI disorders; gastrointestinal motility; microbiome; pharmacogenomics; gastrointestinal oncology

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Advances in Precision Medicine of Oncology Radiotherapy

edited by

Giuseppe Iatí

and Silvana Parisi

submission deadline 15 Dec 2026 | 1 articles | Viewed by 1519 | Submission Open

Keywords: novel radiotherapy approaches; novel drugs; novel diagnostic approaches; immunomodulation; omics; biomarkers; metabolic alterations; personalised medicine

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Multidisciplinary Management of Acute Trauma and Emergency Surgery

edited by Oluwafemi Patrick Owodunni

submission deadline 15 Dec 2026 | 1 articles | Viewed by 1244 | Submission Open

Keywords: trauma; emergency surgery; acute care surgery; trauma systems; prehospital care; resuscitation; critical care; hem-orrhage control; damage control surgery; trauma outcomes

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Interventional Radiology: Towards Personalized Medicine—2nd Edition

edited by

Fabio Corvino

submission deadline 15 Dec 2026 | Viewed by 144 | Submission Open

Keywords: interventional radiology; trauma management; interventional radiology tailored to patients; interventional oncology; diagnostic and interventional radiology; image-guided biopsy

(This special issue belongs to the Section Diagnostics in Personalized Medicine)

Diagnostics and Therapeutics in Ophthalmology—2nd Edition

edited by

Yousif Subhi

submission deadline 20 Dec 2026 | 5 articles | Viewed by 16038 | Submission Open

Keywords: ophthalmology; retina; myopia; glaucoma; cataract; clinical studies; systematic reviews; meta-analyses

(This special issue belongs to the Section Evidence Based Medicine)

Depression and Anxiety: Recent Advances in Personalized Treatment and Management

edited by

Stefano Eleuteri

submission deadline 20 Dec 2026 | 2 articles | Viewed by 5536 | Submission Open

Keywords: personalized treatment; mood disorders and anxiety; treatment; therapy; depression and anxiety

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Management and Treatment in Geriatrics

edited by

Carmen da Casa

and

Juan F. Blanco

submission deadline 20 Dec 2026 | 1 articles | Viewed by 723 | Submission Open

Keywords: geriatrics; personalized health care; artificial intelligence; comprehensive geriatric assessment; ageing; biomedical technology; health promotion; chronic disease management; rehabilitation; pharmacogenetics; neurodegenerative diseases

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

New Approaches in Pharmacogenomics and Functional Genomics

edited by

Su-Jun Lee

submission deadline 20 Dec 2026 | Viewed by 97 | Submission Open

Keywords: personalized medicine; functional genomics; AI-driven tools; machine-learning algorithms; in silico functional prediction platforms; integrative multi-omics analyses; pharmacogenomics education program; drug response; genomic biomarker; healthcare system

(This special issue belongs to the Section Pharmacogenetics)

Personalized Medicine and Surgery in Cardiovascular Disorders

edited by

Quynh Nguyen

and Edward D. Percy

submission deadline 25 Dec 2026 | 2 articles | Viewed by 1842 | Submission Open

Keywords: precision medicine; cardiovascular disorders; cardiogenetics; translational medicine; genomic and multi-omics approaches to cardiovascular diseases

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Personalized Medicine in Urology Surgery: New Challenges and Future Perspectives

edited by

Zisis Kratiras

submission deadline 25 Dec 2026 | Viewed by 100 | Submission Open

Keywords: targeted therapy; molecular markers; minimally invasive interventions; robotic surgery; laparoscopic surgery; targeted therapy; urologic surgery

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Precision Medicine in Cranio-Maxillo-Facial Surgery: Updates and Challenges

edited by

Sergio Olate

submission deadline 28 Dec 2026 | Viewed by 170 | Submission Open

Keywords: maxillofacial surgery; facial plastic surgery; 3D facial surgery; craniomaxillofacial surgery; precision facial treatment

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Diagnosis and Treatment of Hematological Malignancies

edited by Adam S. Zayac

submission deadline 30 Dec 2026 | 1 articles | Viewed by 1039 | Submission Open

Keywords: hematologic malignancies; targeted therapies; myeloid neoplasms; non-hodgkin lymphoma; plasma cell neoplasms; supportive care; immunotherapies; cellular therapies

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Advances in Atrial Fibrillation and Cardiac Arrhythmias: Mechanisms, Diagnosis, and Therapy

edited by Antonios P. Antoniadis and

Paschalis Karakasis

submission deadline 31 Dec 2026 | 3 articles | Viewed by 5828 | Submission Open

Keywords: atrial fibrillation; arrhythmias; pathophysiological mechanisms; electrophysiological; molecular mechanisms; novel approaches; diagnosis; risk prediction; therapeutic strategies; atrial fibrillation ablation; digital health; artificial intelligence; imaging; wearable devices

(This special issue belongs to the Section Mechanisms of Diseases)

Musculoskeletal Diseases: Diagnosis, Rehabilitation and Personalized Treatment

edited by

Giacomo Farì

submission deadline 31 Dec 2026 | 1 articles | Viewed by 4318 | Submission Open

Keywords: rehabilitation; regenerative medicine; telemedicine; musculoskeletal pain; sport; telemedicine; osteoarthritis

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Personalized Medicine in Cardiovascular and Metabolic Diseases

edited by

Gaetano Santulli

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2476 | Submission Open

Keywords: cardiovascular disease; metabolic syndrome; precision health; telemedicine; biomarkers; pharmacogenomics; artificial intelligence; machine learning; epigenetics; diabetes

(This special issue belongs to the Section Mechanisms of Diseases)

Translational Research and Novel Therapeutics in Cutaneous Melanoma

edited by Maja Tolušić Levak and Martina Mihalj

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2463 | Submission Open

Keywords: cutaneus melanoma; immunopathology of melanoma; biomarkers; novel treatments; early diagnosis

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

The Ethnoracial Diversity of Diabetes: Insights into Epidemiology, Genetics, Disease Management, and Personalized Therapies

edited by

Alberto Barcelo

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1690 | Submission Open

Keywords: diabetes disparities; ethnoracial diversity; genetic epidemiology; personalized therapy; health equity

(This special issue belongs to the Section Epidemiology)

Breast Cancer: New Advances in Diagnosis and Personalized Therapies

edited by Pierluigi Maria Rinaldi and Sabatino D'Archi

submission deadline 31 Dec 2026 | 2 articles | Viewed by 1459 | Submission Open

Keywords: breast cancer; Breast Imaging Reporting and Data System 3 (BI-RADS 3); imaging; radiomics; therapy; AI

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

From Biomarkers to Breakthroughs: Advancing Lung Cancer Research

edited by

Konstantinos Syrigos

and

Georgios Evangelou

submission deadline 31 Dec 2026 | 1 articles | Viewed by 726 | Submission Open

Keywords: lung cancer; biomarkers; personalized medicine; molecular diagnostics; targeted therapy; non-small cell lung cancer; small cell lung cancer; resistance mechanisms; translational research; precision oncology

(This special issue belongs to the Section Disease Biomarkers)

Genomics and Precision Medicine

edited by

Trias Thireou

and Louis Papageorgiou

submission deadline 31 Dec 2026 | Viewed by 589 | Submission Open

Keywords: genomics; precision medicine; diagnostics; treatment; genomic test; big data; genomic screening; genomic medicine; genomic biomarker; functional genomics

(This special issue belongs to the Section Omics/Informatics)

Application of Genetic Diagnosis in Pediatrics

edited by Avinash Veerappa

submission deadline 31 Dec 2026 | Viewed by 273 | Submission Open

Keywords: pediatric diagnosis; rare diseases; genome sequencing; exome sequencing; genetic diseases; mutations

(This special issue belongs to the Section Omics/Informatics)

Regenerative Medicine in Cardiovascular Disease

edited by Jaimy Saif and

Claire Stocker

submission deadline 31 Dec 2026 | Viewed by 131 | Submission Open

Keywords: cardiac regeneration; induced pleuripotent stem cells (iPSCs); engineered heart tissue; extracellular vesicles/exosomes; gene and base editing (CRISPR); biomaterials/injectable hydrogels

(This special issue belongs to the Section Mechanisms of Diseases)

Personalized Medicine in Pancreatic Cancer

edited by Nirav Thosani

submission deadline 31 Dec 2026 | Viewed by 104 | Submission Open

Keywords: pancreatic cancer; pancreatic ductal adenocarcinoma; precision oncology; liquid biopsy; tumor microenvironment; radiomics; patient-derived organoids; biomarker-driven therapy; early detection strategies

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Novel and Personalized Treatment Concepts in Gynecologic Cancer—2nd Edition

edited by

Stephan Polterauer

and

Christoph Grimm

submission deadline 15 Jan 2027 | 1 articles | Viewed by 2603 | Submission Open

Keywords: ovarian cancer; endometrial cancer; vulvar cancer; cervical cancer; homologous recombination; targeted therapy; DNA damage repair; biomarkers; imaging; individualized treatment

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Molecular Imaging Application in Personalized Diagnosis and Therapy

edited by

Raheleh Roudi

submission deadline 15 Jan 2027 | Viewed by 88 | Submission Open

Keywords: molecular imaging; positron emission tomography; magnetic resonance imaging; optical imaging; artificial intelligence– driven image analysis; personalized diagnostic

(This special issue belongs to the Section Diagnostics in Personalized Medicine)

Cardiac Disease in Pregnancy: Diagnosis, Management and Outcomes

edited by David S. Majdalany

submission deadline 20 Jan 2027 | 1 articles | Viewed by 2290 | Submission Open

Keywords: maternal cardiac disease; cardio-obstetrics; pregnancy and heart disease; cardiac disease in pregnancy; maternal-fetal medicine

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

New Technologies and Personalized Medicine in Gastrointestinal Surgery

edited by

Marco Inama

submission deadline 20 Jan 2027 | 1 articles | Viewed by 2204 | Submission Open

Keywords: new technologies; robotic surgery; surgical innovation; AI in surgery; new materials in surgery; minimally invasive surgery; personalized medicine; theranostics in gastrointestinale cancer

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

New Insights into Personalized Care in Advance Care Planning

edited by

Mitsunori Nishikawa

submission deadline 25 Jan 2027 | 3 articles | Viewed by 5486 | Submission Open

Keywords: advance care planning; choices about future medical care; cultural differences; diversity; personalized care choices

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Atrial Fibrillation: Toward Personalized Medicine

edited by

Vincenzo Mirco La Fazia

submission deadline 25 Jan 2027 | 1 articles | Viewed by 2855 | Submission Open

Keywords: atrial fibrillation; personalized medicine; genetic predisposition; electroanatomical mapping; pulsed field ablation; genomics; substrate characterization; tailored ablation strategies

(This special issue belongs to the Section Mechanisms of Diseases)

Advanced Imaging and Artificial Intelligence in Personalized Medicine: Innovations and Future Directions

edited by

Amir Hajjam El Hassani

submission deadline 25 Jan 2027 | 1 articles | Viewed by 2531 | Submission Open

Keywords: precision imaging; personalized medicine; radiomics; molecular imaging; artificial intelligence; imaging biomarkers; theranostics; multi-omics integration; predictive modeling; translational research

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Clinical Updates on Personalized Upper Gastrointestinal Surgery

edited by Dimitrios Kehagias

submission deadline 25 Jan 2027 | Viewed by 1322 | Submission Open

Keywords: upper gastrointestinal tract; minimally invasive surgery; anti-reflux surgery; hiatal hernia; achalasia; oesophagogastric resection; personalized treatment; fluorescence guided upper gastrointestinal surgery; anastomotic leakage and perforation of the upper gastrointestinal tract; benign and malignant esophageal diseases; benign and malignant gastric diseases

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Cardiothoracic Surgery: Treatment and Management

edited by

Dania Nachira

submission deadline 25 Jan 2027 | 2 articles | Viewed by 1209 | Submission Open

Keywords: lung cancer; mediastinum; VATS; RATS; cardiothoracic surgery; new technologies; thoracic anesthesia; regional anesthesia

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Emerging Trends in Diagnostic and Interventional Radiology: Towards Personalized Medicine

edited by

Nicola Maggialetti

submission deadline 25 Jan 2027 | 1 articles | Viewed by 670 | Submission Open

Keywords: CT; MRI; interventional radiology; personalized medicine; artificial intelligence; radiomics

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Precision Medicine in Gastrointestinal Neoplasms

edited by Juan Torres-Melero and

María Jose Serrano

submission deadline 25 Jan 2027 | Viewed by 634 | Submission Open

Keywords: digestive cancers; molecular biology; gastrointestinal cancers; gynecological cancers

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Precision Medicine in Otorhinolaryngology: From Diagnostics to Personalized Therapy

edited by

Francesco Giombi

and

Luca Malvezzi

submission deadline 25 Jan 2027 | Viewed by 289 | Submission Open

Keywords: personalized medicine; sinusitis; OSA; molecular antibodies; rhinology; oncology; head and neck; artificial intelligence

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Diagnosis and Treatment of Heart Failure

edited by

Manuel Méndez Bailon

submission deadline 25 Jan 2027 | Viewed by 220 | Submission Open

Keywords: heart failure; acute heart failure; personalized medicine; comorbidities; cardiac electrophysiology; cardiology

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Complex and High-Risk Coronary Interventional Procedures

edited by

Zoltan Ruzsa

, Toth-Gayor Gabor and

Alexandru Achim

submission deadline 31 Jan 2027 | 3 articles | Viewed by 5251 | Submission Open

Keywords: complex high-risk intervention (CHIP); coronary bifurcation; coronary chronic total occlusion; severe coronary calcification; protected PCI; access site I during CHIP procedures

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Advances in Colorectal Cancer: Diagnosis and Personalized Treatment

edited by Georgios Polychronidis

submission deadline 31 Jan 2027 | 3 articles | Viewed by 2950 | Submission Open

Keywords: colorectal cancer; diagnosis; personalized medicine; targeted therapy; immunotherapy; liquid biopsy; molecular profiling; surgical oncology; artificial intelligence; precision oncology

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

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