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Life
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Immune Alteration and Immune Response in Human Diseases
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Immune Alteration and Immune Response in Human Diseases

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 3589

Special Issue Editors

Dr. Laura Ancuta Pop

E-Mail Website
Guest Editor
Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania
Interests: next generation sequencing, cancer, genomics; genetics
Special Issues, Collections and Topics in MDPI journals
Dr. Cristina Ciocan

E-Mail Website
Guest Editor
Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania

Special Issue Information

Dear Colleagues,

This Special Issue highlights recent work related to immune alterations and response in human diseases related to different infections, microbiome profiles and immunity. We would like to compare specific biological and biochemical processes to the immunity of different patients with different diseases. 

We are seeking contributions (research and review articles) that cover a broad range of topics associated with immune alteration, disorders of the immune system, immunity and aging, including (but not limited to) the following:

  • Methods for studying immune response in human diseases;
  • Alteration of the immune system in human diseases;
  • Immune system and aging;
  • Microbiome and immunity;
  • Immunity and children;
  • Immune and tumor microenvironment alteration in cancer.

Dr. Laura Ancuta Pop
Dr. Cristina Ciocan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • immune alterations
  • microbiome
  • immune response
  • immunity
  • aging
  • cancer

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

10 pages, 603 KiB  
Article
The Challenge of Misleading Information: Does the Interaction between Zinc and Vitamin D Influence the Immune Response against SARS-CoV-2 in the Elderly Population?
by Deise Maria Rego Rodrigues Silva, Pedro Henrique Macedo Moura, Rajiv Gandhi Gopalsamy, Eloia Emanuelly Dias Silva, Marina dos Santos Barreto, Ronaldy Santana Santos, Pamela Chaves de Jesus, Jessiane Bispo de Souza, Lucas Alves da Mota Santana, Adriana Gibara Guimarães and Lysandro Pinto Borges
Life 2024, 14(10), 1277; https://doi.org/10.3390/life14101277 - 8 Oct 2024
Viewed by 1367
Abstract
Immunization is a challenge for the elderly population and can leave this group more vulnerable to opportunistic pathogens such as SARS-CoV-2. Due to this situation, while vaccines were in the development phase, hypotheses were raised about the role of vitamins and minerals in [...] Read more.
Immunization is a challenge for the elderly population and can leave this group more vulnerable to opportunistic pathogens such as SARS-CoV-2. Due to this situation, while vaccines were in the development phase, hypotheses were raised about the role of vitamins and minerals in immunization. In Brazil, there was a controversy regarding the well-known COVID-19 Kit, a standardized prescription for positive cases that contained zinc, and vitamin D, and anti-parasitic drugs. There was great controversy in scientific circles, since COVID-19 brought a major challenge for health professionals and public authorities: misleading information. In this study, we evaluated the role of vitamin D and zinc in the production of anti-SARS-CoV-2 neutralizing antibodies (NAbs) in a group of elderly residents in a nursing home in northeastern Brazil. Serum levels of COVID-19 NAbs were assessed, along with vitamin D and zinc, in two phases. The first (T1) was in August 2022 with 26 elderly people, and the second (T2) was in March 2023 with 21, due to the death of five participants. Overall, we observed satisfactory levels for vitamin D, with no participants showing a deficiency in either test, and zinc, with only two participants having a negative result at T1 and three at T2. However, a drop in the average number of NAbs was observed, especially in women (T1 = 89 ± 19 vs. T2 = 57 ± 44), highlighting the importance of monitoring this immunological parameter in the population studied. Based on the results, we suggest that there is no synergism between the micronutrients studied and NAbs (p > 0.05). Further studies are needed to consolidate the findings of an absence of synergism between vitamin D and zinc in the maintenance of NAbs. Full article
(This article belongs to the Special Issue Immune Alteration and Immune Response in Human Diseases)
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12 pages, 3039 KiB  
Article
Struggling with COVID-19 in Adult Inborn Errors of Immunity Patients: A Case Series of Combination Therapy and Multiple Lines of Therapy for Selected Patients
by Patrick Bez, Giancarlo D’ippolito, Carla Maria Deiana, Renato Finco Gambier, Andrea Pica, Giulia Costanzo, Giulia Garzi, Riccardo Scarpa, Nicholas Landini, Francesco Cinetto, Davide Firinu and Cinzia Milito
Life 2023, 13(7), 1530; https://doi.org/10.3390/life13071530 - 8 Jul 2023
Cited by 5 | Viewed by 1756
Abstract
Background: The SARS-CoV-2 infection is now a part of the everyday lives of immunocompromised patients, but the choice of treatment and the time of viral clearance can often be complex, exposing patients to possible complications. The role of the available antiviral and monoclonal [...] Read more.
Background: The SARS-CoV-2 infection is now a part of the everyday lives of immunocompromised patients, but the choice of treatment and the time of viral clearance can often be complex, exposing patients to possible complications. The role of the available antiviral and monoclonal therapies is a matter of debate, as are their effectiveness and potential related adverse effects. To date, in the literature, the amount of data on the use of combination therapies and on the multiple lines of anti-SARS-CoV-2 therapy available to the general population and especially to inborn error of immunity (IEI) patients is small. Methods: Here, we report a case series of five adult IEI patients managed as inpatients at three Italian IEI referral centers (Rome, Treviso, and Cagliari) treated with combination therapy or multiple therapeutic lines for SARS-CoV-2 infection, such as monoclonal antibodies (mAbs), antivirals, convalescent plasma (CP), mAbs plus antiviral, and CP combined with antiviral. Results: This study may support the use of combination therapy against SARS-CoV-2 in complicated IEI patients with predominant antibody deficiency and impaired vaccine response. Full article
(This article belongs to the Special Issue Immune Alteration and Immune Response in Human Diseases)
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