Immune Alteration and Immune Response in Human Diseases

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 1560

Special Issue Editors


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Guest Editor
Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania
Interests: next generation sequencing, cancer, genomics; genetics
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania

Special Issue Information

Dear Colleagues,

This Special Issue highlights recent work related to immune alterations and response in human diseases related to different infections, microbiome profiles and immunity. We would like to compare specific biological and biochemical processes to the immunity of different patients with different diseases. 

We are seeking contributions (research and review articles) that cover a broad range of topics associated with immune alteration, disorders of the immune system, immunity and aging, including (but not limited to) the following:

  • Methods for studying immune response in human diseases;
  • Alteration of the immune system in human diseases;
  • Immune system and aging;
  • Microbiome and immunity;
  • Immunity and children;
  • Immune and tumor microenvironment alteration in cancer.

Dr. Laura Ancuta Pop
Dr. Cristina Ciocan
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • immune alterations
  • microbiome
  • immune response
  • immunity
  • aging
  • cancer

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Published Papers (1 paper)

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Research

12 pages, 3039 KiB  
Article
Struggling with COVID-19 in Adult Inborn Errors of Immunity Patients: A Case Series of Combination Therapy and Multiple Lines of Therapy for Selected Patients
by Patrick Bez, Giancarlo D’ippolito, Carla Maria Deiana, Renato Finco Gambier, Andrea Pica, Giulia Costanzo, Giulia Garzi, Riccardo Scarpa, Nicholas Landini, Francesco Cinetto, Davide Firinu and Cinzia Milito
Life 2023, 13(7), 1530; https://doi.org/10.3390/life13071530 - 8 Jul 2023
Cited by 3 | Viewed by 1269
Abstract
Background: The SARS-CoV-2 infection is now a part of the everyday lives of immunocompromised patients, but the choice of treatment and the time of viral clearance can often be complex, exposing patients to possible complications. The role of the available antiviral and monoclonal [...] Read more.
Background: The SARS-CoV-2 infection is now a part of the everyday lives of immunocompromised patients, but the choice of treatment and the time of viral clearance can often be complex, exposing patients to possible complications. The role of the available antiviral and monoclonal therapies is a matter of debate, as are their effectiveness and potential related adverse effects. To date, in the literature, the amount of data on the use of combination therapies and on the multiple lines of anti-SARS-CoV-2 therapy available to the general population and especially to inborn error of immunity (IEI) patients is small. Methods: Here, we report a case series of five adult IEI patients managed as inpatients at three Italian IEI referral centers (Rome, Treviso, and Cagliari) treated with combination therapy or multiple therapeutic lines for SARS-CoV-2 infection, such as monoclonal antibodies (mAbs), antivirals, convalescent plasma (CP), mAbs plus antiviral, and CP combined with antiviral. Results: This study may support the use of combination therapy against SARS-CoV-2 in complicated IEI patients with predominant antibody deficiency and impaired vaccine response. Full article
(This article belongs to the Special Issue Immune Alteration and Immune Response in Human Diseases)
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