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Life
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Advances in Treatments of Oral Cancer/Tumor
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Advances in Treatments of Oral Cancer/Tumor

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: closed (29 January 2024) | Viewed by 716

Special Issue Editors

Dr. Shankargouda Patil

E-Mail Website
Guest Editor
College of Dental Medicine, Roseman University of Health Sciences, South Jordan, UT 84095, USA
Interests: oral oncology; regenerative medicine; stem cells
Special Issues, Collections and Topics in MDPI journals
Dr. Claudia M. Tellez Freitas

E-Mail Website
Guest Editor
College of Dental Medicine, Roseman University of Health Sciences, South Jordan, UT 84095, USA
Interests: Artificial Intelligence; cancer immunotherapy; cancer vaccines; checkpoint inhibitors; personalized medicine; target gene therapy

Special Issue Information

Dear Colleagues,

The standard protocol for the treatment of oral tumors including oral squamous cell carcinoma is surgical resection with adjunct chemotherapy and/or radiotherapy. A common issue with the current treatment protocol is the resistance shown by cancer cells. In addition, radical surgical interventions and the cytotoxic effects of adjunct therapies often lead to significant morbidity, drastically reducing the quality of life. Thus, a modality capable of targeting the cancer cells, overcoming any potential resistance, and minimizing any potential morbidity is needed. Examples of new avenues working in this effort are immunotherapies, gene therapy, and even intraarterial chemotherapy. The main purpose of these novel avenues to treat oral cancer is to improve the survival and quality of life of oral cancer patients. The present Special Issue focuses on innovative research work aimed at developing improved or novel therapeutic strategies targeting oral tumors.

Prof. Dr. Shankargouda Patil
Dr. Claudia M. Tellez Freitas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Artificial Intelligence
  • cancer immunotherapy
  • cancer vaccines
  • checkpoint inhibitors
  • personalized medicine
  • target gene therapy

Published Papers (1 paper)

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Research

16 pages, 1325 KiB  
Article
Downstream Target Analysis for miR-365 among Oral Squamous Cell Carcinomas Reveals Differential Associations with Chemoresistance
by Brendon Yu, Nathaniel Kruse, Katherine M. Howard and Karl Kingsley
Life 2024, 14(6), 741; https://doi.org/10.3390/life14060741 - 10 Jun 2024
Viewed by 427
Abstract
Expression of microRNAs, such as miR-365, is known to be dysregulated in many tumors, including oral cancers, although little is known about their role or functions. The objective of this project is to evaluate the downstream targets of miR-365 to determine any potential [...] Read more.
Expression of microRNAs, such as miR-365, is known to be dysregulated in many tumors, including oral cancers, although little is known about their role or functions. The objective of this project is to evaluate the downstream targets of miR-365 to determine any potential pathways or effects. Downstream targets for miR-365 (miRdatabase target scores > 90) were used for qPCR screening of oral cancer cell lines (SCC4, SCC9, SCC15, SCC25, CAL27). Each oral cancer cell line expressed miR-365 downstream targets molybdenum cofactor synthesis-2 (MOCS2), erythropoietin receptor (EPOR), IQ motif containing-K (IQCK), carboxypeptidase A3 (CPA3), solute carrier family 24 member-3 (SLC24A3), and coiled-coil domain containing 47 (CCDC47)—although the expression levels varied somewhat. However, differential results were observed with ubiquitin protein ligase E3 component n-recognin-3 (UBR3), nudix hydrolase-12 (NUDT12), zinc finger CCHC-type containing-14 (ZCCHC14), and homeobox and leucine zipper encoding (HOMEZ). These data suggest that many of the miR-365 targets are expressed in the oral cancers screened, with the differential expression of UBR3, ZCCHC14, HOMEZ, and NUDT12, which may be correlated with chemoresistance among two specific oral cancer cell lines (SCC25, SCC9). These results suggest this differential expression may signal potential targets for patient treatment with tumors exhibiting miR-365 and chemotherapeutic resistance. Full article
(This article belongs to the Special Issue Advances in Treatments of Oral Cancer/Tumor)
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