The Health Impact of Changes in the Microbiota

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Microbiology".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 2012

Special Issue Editor


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Guest Editor
1. Center of Biomedical Research, Institute of Nutrition and Food Technology “José Mataix”, University of Granada, Avda. del Conocimiento s/n., Armilla, 18016 Granada, Spain
2. Instituto de Investigación Biosanitaria ibs.GRANADA, Complejo Hospitalario Universitario de Granada, 18014 Granada, Spain
3. Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, 18071 Granada, Spain
Interests: microbiota; cancer; metabolic disorders; gut microbiota; diet; liver
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Special Issue Information

Dear Colleagues,

The gut microbiota is a complex population of microorganisms, including viruses, bacteria, archaea and fungi, which subsists within the gastrointestinal ecosystem. In human health, the gut microbiota is involved in a dynamic interplay with the host from birth to the senescence settled during childhood. Its primary function is to maintain a balance with the host, playing both local and remote roles in critical physiological processes, particularly inflammation and immune response. The composition of gut microbiota is mediated by various factors, such as host characteristics, environmental pollutants, geographical location, bacterial infections, antibiotic treatment, lifestyle, surgical procedures, nutrition and age. Alterations in this complex system have been related to the risk of many disease.

This Special Issue aims to provide new insights into the relationship between gut microbes and health. We welcome papers, including original research articles and up-to-date reviews, exploring the mechanisms involved in the gut microbiota changes and determining the influence of those changes on the predisposition or risk of disease development.

Dr. Ana Isabel Alvarez-Mercado
Guest Editor

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Keywords

  • microbiota/microbiome and health
  • dysbiosis
  • environmental pollutants
  • xenobiotic
  • metabolic disorders
  • diet
  • health
  • microbiota–host symbiosis
  • age diet
  • probiotics
  • prebiotics

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Published Papers (1 paper)

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16 pages, 1650 KiB  
Systematic Review
Epigenetics, Microbiota, and Breast Cancer: A Systematic Review
by Alba Soldado-Gordillo and Ana Isabel Álvarez-Mercado
Life 2024, 14(6), 705; https://doi.org/10.3390/life14060705 - 30 May 2024
Viewed by 1737
Abstract
Breast cancer is the most frequently diagnosed cancer in women worldwide. According to recent studies, alterations in the microbiota and epigenetic modulations are risk factors for this disease. This systematic review aims to determine the possible associations between the intestinal and mammary microbial [...] Read more.
Breast cancer is the most frequently diagnosed cancer in women worldwide. According to recent studies, alterations in the microbiota and epigenetic modulations are risk factors for this disease. This systematic review aims to determine the possible associations between the intestinal and mammary microbial populations, epigenetic modifications, and breast cancer. To achieve this objective, we conducted a literature search in the PubMed, Web of Science, and Science Direct databases following the PRISMA guidelines. Although no results are yet available in humans, studies in mice suggest a protective effect of maternal dietary interventions with bioactive compounds on the development of breast tumors in offspring. These dietary interventions also modified the gut microbiota, increasing the relative abundance of short-chain fatty acid-producing taxa and preventing mammary carcinogenesis. In addition, short-chain fatty acids produced by the microbiota act as epigenetic modulators. Furthermore, some authors indicate that stress alters the gut microbiota, promoting breast tumor growth through epigenetic and gene expression changes in the breast tumor microenvironment. Taken together, these findings show the ability of epigenetic modifications and alterations of the microbiota associated with environmental factors to modulate the development, aggressiveness, and progression of breast cancer. Full article
(This article belongs to the Special Issue The Health Impact of Changes in the Microbiota)
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