Hand Soft Tissue Disorders: Mechanisms and Therapeutic Advances

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 26 August 2025 | Viewed by 690

Special Issue Editor


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Guest Editor
1. Department of Plastic and Reconstructive Surgery, Frankston Hospital, Peninsula Health, Frankston, VIC 3199, Australia
2. Faculty of Medicine and Surgery, Monash University, Melbourne, VIC 3800, Australia
Interests: hand surgery; trauma surgery; artificial intelligence; breast surgery

Special Issue Information

Dear Colleagues,

Hand soft tissue disorders encompass various conditions, including Dupuytren’s disease, trigger finger, and tendon injuries, which significantly impact hand function and quality of life. Recent advancements in genomics, molecular biology, and biomarker identification have shed new light on the mechanisms underlying these disorders, paving the way for innovative therapeutic strategies. This Special Issue, entitled "Hand Soft Tissue Disorders: Mechanisms and Therapeutic Advances," aims to bring together cutting-edge research exploring the etiology, pathophysiology, and use of artificial intelligence in the clinical management of hand soft tissue disorders. Key topics include the role of genomics in precision medicine, biomarker discovery for diagnosis and treatment monitoring, and the development of novel interventions, including surgical, pharmacological, and regenerative approaches. We invite submissions that encompass original research and reviews, with a focus on integrating basic science with clinical applications. By fostering multidisciplinary collaboration, this Special Issue seeks to advance understanding and improve patient outcomes for these complex conditions.

Dr. Ishith Seth
Guest Editor

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Keywords

  • dupuytren’s disease
  • hand soft tissue disorders
  • genomics
  • biomarkers
  • artificial intelligence

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Published Papers (1 paper)

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13 pages, 2012 KiB  
Systematic Review
Collagenase Clostridium Histolyticum Versus Percutaneous Needle Fasciotomy for Dupuytren’s Disease: A Systematic Review and Meta-Analysis
by Ishith Seth, Vicki McClure, Bryan Lim, Roberto Cuomo, Richard J. Ross and Warren M. Rozen
Life 2025, 15(2), 259; https://doi.org/10.3390/life15020259 - 8 Feb 2025
Viewed by 543
Abstract
Minimally invasive treatments for Dupuytren’s disease (DD), such as percutaneous needle fasciotomy (PNF) and collagenase clostridium histolyticum (CCH), have become alternatives to open surgeries. This meta-analysis compared these treatments in terms of complications, patient satisfaction, clinical outcomes, and recurrence. Relevant studies up to [...] Read more.
Minimally invasive treatments for Dupuytren’s disease (DD), such as percutaneous needle fasciotomy (PNF) and collagenase clostridium histolyticum (CCH), have become alternatives to open surgeries. This meta-analysis compared these treatments in terms of complications, patient satisfaction, clinical outcomes, and recurrence. Relevant studies up to June 2024 were identified through major databases, following PRISMA guidelines, and the study was registered on PROSPERO. Statistical analysis using Review Manager 5.4 found PNF had lower post-operative rates of oedema (RR = 0.15, 95% CI [0.09, 0.27], p < 0.00001), lymphadenopathy (RR = 0.09, 95% CI [0.02, 0.38], p = 0.0010), and pruritus (RR = 0.1, 95% CI [0.01, 0.73], p = 0.02) compared to CCH. However, there were no significant differences in skin tears, recurrence, reintervention, extension deficit, or residual flexion at metacarpal and proximal interphalangeal joints (p > 0.05). Patient-reported outcomes, including QuickDASH and URAM scores, also showed no significant differences. Eleven studies involving 1443 patients were analysed, and most were at a low-to-moderate risk of bias, as assessed using the Cochrane or Newcastle–Ottawa tools. While PNF showed fewer minor complications, overall clinical and patient-reported outcomes were comparable between the treatments. These findings highlight the need to tailor treatment choices to patient preferences and clinical context. Full article
(This article belongs to the Special Issue Hand Soft Tissue Disorders: Mechanisms and Therapeutic Advances)
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