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Life
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Personalized Medicine in Ophthalmic Diseases: Updated Challenges and Opportunities
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Personalized Medicine in Ophthalmic Diseases: Updated Challenges and Opportunities

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 29 August 2025 | Viewed by 2958

Special Issue Editor

Dr. Camelia Margareta Bogdanici

E-Mail Website
Guest Editor
Department of Ophthalmology, University of Medicine and Pharmacy “Grigore T. Popa”, 700115 Iasi, Romania
Interests: pediatric ophthalmology; glaucoma; neuroophthalmology; ocular surface disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Medical practice in ophthalmology is always advancing. With the continuous development of novel diagnostic and treatment technologies, such as gene therapy, imaging modalities, nanotechnology, and molecular treatment, and by using artificial intelligence, we hope to gain access to a more personalized form of ophthalmic care for our patients.

This Special Issue aims to facilitate the understanding of the challenges that ophthalmic diseases present and how they affect each patient, while also providing the opportunity of sharing and discussing recent ophthalmological knowledge in a comprehensive manner.   

Therefore, we invite you to contribute to this Special Issue with original articles and reviews based on clinical and experimental research. Papers from all subspecialities of ophthalmology are welcome, as they could provide a more personal approach to ophthalmological conditions.

Dr. Camelia Margareta Bogdanici
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • vision-related quality of life
  • personalized medicine
  • artificial intelligence
  • ophthalmology and nutrition
  • optical coherence tomography
  • ocular surface diseases
  • retinal vascular diseases

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

8 pages, 629 KiB  
Article
Preoperative Ocular Biometric Parameters as Predictors of Intraocular Pressure Reduction After Phacoemulsification Cataract Surgery in Non-Glaucomatous Eyes
by Feyzahan Uzun, Hüseyin Findik and Muhammet Kaim
Life 2025, 15(3), 381; https://doi.org/10.3390/life15030381 - 28 Feb 2025
Viewed by 466
Abstract
Purpose: This study aimed to evaluate the relationship between preoperative ocular biometric parameters and intraocular pressure (IOP) reduction after phacoemulsification in non-glaucomatous eyes. Methods: The charts of non-glaucomatous patients who underwent phacoemulsification and lens implantation were retrospectively reviewed. IOP was measured preoperatively and [...] Read more.
Purpose: This study aimed to evaluate the relationship between preoperative ocular biometric parameters and intraocular pressure (IOP) reduction after phacoemulsification in non-glaucomatous eyes. Methods: The charts of non-glaucomatous patients who underwent phacoemulsification and lens implantation were retrospectively reviewed. IOP was measured preoperatively and 3 months after surgery. The change in IOP and its relation to ocular biometric parameters, including anterior chamber depth (ACD), lens thickness (LT), axial length (AL), and central corneal thickness (CCT), measured preoperatively by LENSTAR LS 900 (Haag-Streit, Inc., Koeniz, Switzerland), were evaluated. The impact of each parameter on the alteration in IOP was assessed using a regression model. Results: The analysis included 171 eyes of 145 patients, with a mean age of 68.7 ± 11 years. The average IOP reduction following cataract surgery was 3.0 ± 2.9 mmHg, decreasing from a preoperative mean of 16.3 ± 2.8 mmHg. The amount of IOP reduction showed statistically significant correlations with preoperative ocular parameters. Eyes with shallower anterior chambers demonstrated a greater IOP reduction (r = −0.307, p = 0.034), as did those with thicker lenses (r = 0.383, p = 0.026). Multivariate regression analysis further confirmed that higher preoperative IOP, shallower ACD, and thicker lenses were independently associated with greater postoperative IOP decreases (p < 0.001). AL and CCT did not exhibit significant associations with IOP reduction. Conclusions: The amount of IOP reduction is significantly greater in eyes with higher preoperative IOP, thicker lenses, and shallower anterior chamber after cataract surgery in non-glaucomatous eyes. Full article
(This article belongs to the Special Issue Personalized Medicine in Ophthalmic Diseases: Updated Challenges and Opportunities)
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11 pages, 3000 KiB  
Article
Variabilities in Retinal Hemodynamics Across the Menstrual Cycle in Healthy Women Identified Using Optical Coherence Tomography Angiography
by Vlad Constantin Donica, Alexandra Lori Donica, Irina Andreea Pavel, Ciprian Danielescu, Anisia Iuliana Alexa and Camelia Margareta Bogdănici
Life 2025, 15(1), 22; https://doi.org/10.3390/life15010022 - 28 Dec 2024
Viewed by 667
Abstract
Background: Numerous conditions, both physiological and pathological, can influence changes in the retinal vascular architecture. In order to be able to highlight pathological aspects of systemic diseases with ocular activity, it is necessary to understand how physiological fluctuations can influence circulation at the [...] Read more.
Background: Numerous conditions, both physiological and pathological, can influence changes in the retinal vascular architecture. In order to be able to highlight pathological aspects of systemic diseases with ocular activity, it is necessary to understand how physiological fluctuations can influence circulation at the retinal level. The present study attempts to evaluate retinal and choroidal vascular and structural changes in healthy female subjects over the course of a menstrual cycle using OCT-A. Methods: We analyzed 22 eyes from healthy reproductive women with a regular menstrual cycle. We performed five OCT-A scans of the subjects every 7–8 days over the course of a month starting from the first day of the menstrual cycle and ending with the first day of the next cycle, measuring perfusion density in the superficial and deep vascular plexuses, choroidal thickness, and FAZ perimeter. Results: There are physiological variations in retinal hemodynamics that can be identified using OCT-A, choroidal thickness having statistically significant increased values in the parafoveal nasal sector during the ovulatory phase (289.18 µm) compared to the early follicular phase (281.9 µm), and the subfoveal sector during the ovulatory phase (319.04 µm) compared to the early follicular phase (308.27 µm). Conclusions: These findings along with abnormally small FAZ perimeters indicate that the menstrual cycle phase should be considered whenever interpreting OCT-A results. Further studies that include larger cohorts, control groups, and hormone serum levels are necessary to confirm and correlate retinal vascular alterations and the phase of the menstrual cycle using OCT-A. Full article
(This article belongs to the Special Issue Personalized Medicine in Ophthalmic Diseases: Updated Challenges and Opportunities)
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14 pages, 2160 KiB  
Article
Tracking Macular Sensitivity and Inner Retinal Thickness in Long-Term Type 1 Diabetes: A Five-Year Prospective Examination in Patients without Diabetic Retinopathy
by Guisela Fernández-Espinosa, Elvira Orduna-Hospital, María Sopeña-Pinilla, Marta Arias-Álvarez, Ana Boned-Murillo, María Dolores Díaz-Barreda, Ana Sánchez-Cano and Isabel Pinilla
Life 2024, 14(9), 1152; https://doi.org/10.3390/life14091152 - 12 Sep 2024
Viewed by 969
Abstract
The aim of the study is to compare macular sensitivity and retinal thickness in patients with long-term type 1 diabetes mellitus (DM1) without diabetic retinopathy (DR) after 5 years of follow-up. Thirty-two eyes from 32 long-term DM1 patients without DR were included. All [...] Read more.
The aim of the study is to compare macular sensitivity and retinal thickness in patients with long-term type 1 diabetes mellitus (DM1) without diabetic retinopathy (DR) after 5 years of follow-up. Thirty-two eyes from 32 long-term DM1 patients without DR were included. All participants underwent a complete ophthalmological examination, including microperimetry and spectral domain optical coherence tomography (SD-OCT). The data were compared with results from 5 years prior. The mean age of the DM1 patients was 43.19 ± 10.17 years, with a mean disease duration of 29.84 ± 8.98 years and good glycemic control. In 2023, patients exhibited a significantly worse best corrected visual acuity (BCVA) compared to 2018 (p < 0.001). DM1 patients did not show statistically significant changes in macular sensitivity over the 5-year follow-up period. Macular integrity showed significant differences between the two time points (p = 0.045). Retinal thickness showed significant differences, particularly in inner retinal layers (IRL) across most of the ETDRS areas. Long-term DM1 patients without DR lesions showed worsened macular integrity and a lower BCVA in 2023. Additionally, they displayed significant alterations in retinal thicknesses, especially in the IRL, between 2018 and 2023. These findings suggest that even in the absence of visible DR, long-term DM1 patients may experience subclinical retinal changes and functional deterioration over time, highlighting the importance of regular monitoring for the early detection and management of potential complications. Full article
(This article belongs to the Special Issue Personalized Medicine in Ophthalmic Diseases: Updated Challenges and Opportunities)
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