Mitochondrial Bioenergetics and Redox Metabolism in Neuronal Health and Disease
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: closed (28 February 2024) | Viewed by 203
Special Issue Editors
Interests: mitochondrial function, active oxygen species and nitric oxide metabolism in the nervous system; studies of aging and drug neurotoxicity
Interests: mitochondrial function; intrasynaptic mitochondria properties; mitochondria in neurotransmission; neurotoxic drugs
Interests: mitochondrial carriers; mitochondria; excitotoxicity; myelination; neuroprotection; mitochondrial disorders; neurodegeneration; neuroenergetics; Aralar/AGC1; malate-aspartate NADH shuttle
Special Issue Information
Dear Colleagues,
Neuronal function and survival critically depend upon mitochondrial function. Mitochondrial generation of ATP from the respiratory chain and oxidative phosphorylation is essential to satisfy the high energy requirements associated with the maintenance of ion gradients, firing and propagation of action potentials, and calcium buffering during neurotransmission. In addition, mitochondria play a crucial role in the generation of reactive oxygen species, which have lately emerged as special molecules involved in the modulation of transcription factors and signaling pathways associated with the intracellular response to oxidative stress.
Due to the complex architecture of neurons, mitochondria need to be moved up to distal neuronal zones to reach the nerve terminals through axonal transport, which represents another high-energy-demanding process. Regarding mitochondrial fusion–fission properties, mitochondria reshaping and mitophagy are among some of the events that can be involved in the response to different stimuli. Alterations in mitochondrial trafficking and dynamics, bioenergetic function, and oxidative stress have been established as important features in neurodegenerative pathologies, such as Parkinson’s diseases, Alzheimer’s diseases, and Huntington’s disease, as well as well as multiple sclerosis, among others. In addition, alterations in several neurotransmitter systems associated with schizophrenia and autism disorders can affect mitochondrial bioenergetics, redox balance impairment, and calcium deregulation in the brain. Finally, the ability of mitochondria to sense and respond to stressors can be crucial to cell fate in situations of physiological stress and post-traumatic stress disorder.
The Special Issue “Mitochondrial Bioenergetics and Redox Metabolism in Neuronal Health and Disease” will be focused on synaptic bioenergetic function and redox status both in brain health and in neurodegenerative disorders.
Dr. Silvia Lores-Arnaiz
Dr. Georgina Rodríguez de Lores Arnaiz
Prof. Dr. Beatriz Pardo Merino
Guest Editors
Manuscript Submission Information
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Keywords
- mitochondrial bioenergetics
- intrasynaptic mitochondria
- active oxygen species
- redox metabolism
- neurodegenerative diseases
- brain disorders
