Alzheimer's Disease: From Pathogenesis to Therapy
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: closed (26 January 2024) | Viewed by 4423
Special Issue Editors
Interests: Alzheimer's disease; immunogenetics; HLA typing; neurodegenerative diseases
Special Issues, Collections and Topics in MDPI journals
Interests: Alzheimer's disease; autoimmunity; immunogenetics; neurodegenerative diseases; neuroinflammation; multiple sclerosis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Alzheimer's disease (AD) is the most common neurodegenerative disorder in elderly individuals. Characterized by a complex pathogenic and clinical profile involving neuronal dysfunction, progressive brain atrophy, and cognitive decline, AD is the leading cause of dementia worldwide, with approximately 50 million cases, and poses a substantial medical and socio-economic burden. Despite significant advancements in recent decades, the processes leading to AD-related pathology remain poorly understood. Ongoing efforts to unravel the key cellular and molecular players involved in the development of amyloid and tau pathology, neuroinflammation, neurodegeneration, and other abnormalities offer promising prospects for the identification of new screening and diagnostic biomarkers, as well as the development of novel therapeutic strategies.
In this Special Issue, we aim to publish review and original research articles on the etiology, pathogenesis, diagnostics, and therapy of AD. We invite submissions addressing a broad range of topics including, but not limited to, the following aspects of AD:
- Genetic, epigenetic, environmental, and life-style risk factors for AD;
- The role of the immune system, oxidative stress, mitochondrial dysfunction, endocrine, metabolic and other alterations in the development of AD;
- The potential link between the gut microbiome and AD;
- Novel biomarkers for AD diagnostics;
- Emerging therapeutic approaches.
We welcome contributions that shed light on these areas and advance our understanding of Alzheimer's disease.
Dr. Ivana Shawkatová
Dr. Juraj Javor
Guest Editors
Manuscript Submission Information
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Keywords
- Alzheimer's disease
- biomarkers
- epigenetics
- genetics
- genomics
- immune mediators
- neurodegeneration
- neuroinflammation
- proteomics, risk factors
- therapy
- transcriptomics
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