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Life
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Endothelial Dysfunction in Cardiopulmonary Diseases—Effects of the Micro- and Macro-Environment
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Endothelial Dysfunction in Cardiopulmonary Diseases—Effects of the Micro- and Macro-Environment

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: closed (24 June 2022) | Viewed by 5443

Special Issue Editors

Dr. Olga Tura-Ceide

E-Mail Website
Guest Editor
Department of Pulmonary Medicine, Dr. Josep Trueta University Hospital de Girona, Santa Caterina Hospital de Salt and the Girona Biomedical Research Institut (IDIBGI), 17190 Girona, Spain
Interests: endothelial progenitor cells; angiogenesis; pulmonary hypertension; endothelial dysfunction; thromboembolism
Special Issues, Collections and Topics in MDPI journals
Dr. Robert Szulcek

E-Mail Website
Guest Editor
Institute of Physiology, Charité-Universitätsmedizin Berlin and German Heart Center Berlin (DHZB), 13353 Berlin, Germany
Interests: endothelial cells; vascular biology; mechanobiology; space biology; respiratory diseases; pulmonary hypertension; pulmonary thrombosis; disease modeling
Dr. Elena López-Ruíz

E-Mail Website
Guest Editor
1. Excellence Research Unit "Modeling Nature" (MNat), Department of Health Sciences, University of Jaén, Jaén, Spain
2. Biosanitary Research Institute of Granada (ibs.GRANADA), Granada, Spain
Interests: tissue engineering; regenerative medicine; biomaterials; bioinks; 3D bioprinting; decellularized matrix; stem cells
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue will focus on the importance of endothelial dysfunction in the appearance and development of many cardiopulmonary diseases. We seek new, promising novel biomarkers of endothelial dysfunction and the development of innovative 2D and 3D in vitro and in vivo models to recapitulate the disease. Studies on tissue engineering, lung-on-a-chip systems, metabolomics, human cell-derived systems, etc. will be welcomed. Additionally, the Special Issue will particularly focus on the definition of the (patho)physiological endothelial responses to micro- and macro-environmental influences that trigger endothelial dysfunction and pathological abnormalities.

Dr. Olga Tura-Ceide
Dr. Robert Szulcek
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Endothelial dysfunction
  • Cardiovascular diseases
  • Respiratory diseases
  • In vitro models
  • Patient-derived cell assays
  • Angiogenesis
  • Animal models
  • Bioprinting
  • 3D assays
  • Environmental influences
  • Epigenetics

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Published Papers (2 papers)

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Research

14 pages, 2565 KiB  
Article
Linking In Vitro Models of Endothelial Dysfunction with Cell Senescence
by Francisco R. Jimenez Trinidad, Marta Arrieta Ruiz, Núria Solanes Batlló, Àngela Vea Badenes, Joaquim Bobi Gibert, Antoni Valera Cañellas, Mercè Roqué Moreno, Xavier Freixa Rofastes, Manel Sabaté Tenas, Ana Paula Dantas, Olga Tura-Ceide and Montserrat Rigol Muxart
Life 2021, 11(12), 1323; https://doi.org/10.3390/life11121323 - 30 Nov 2021
Cited by 6 | Viewed by 2475
Abstract
Endothelial cell dysfunction is the principal cause of several cardiovascular diseases that are increasing in prevalence, healthcare costs, and mortality. Developing a standardized, representative in vitro model of endothelial cell dysfunction is fundamental to a greater understanding of the pathophysiology, and to aiding [...] Read more.
Endothelial cell dysfunction is the principal cause of several cardiovascular diseases that are increasing in prevalence, healthcare costs, and mortality. Developing a standardized, representative in vitro model of endothelial cell dysfunction is fundamental to a greater understanding of the pathophysiology, and to aiding the development of novel pharmacological therapies. We subjected human umbilical vein endothelial cells (HUVECs) to different periods of nutrient deprivation or increasing doses of H2O2 to represent starvation or elevated oxidative stress, respectively, to investigate changes in cellular function. Both in vitro cellular models of endothelial cell dysfunction-associated senescence developed in this study, starvation and oxidative stress, were validated by markers of cellular senescence (increase in β-galactosidase activity, and changes in senescence gene markers SIRT1 and P21) and endothelial dysfunction as denoted by reductions in angiogenic and migratory capabilities. HUVECs showed a significant H2O2 concentration-dependent reduction in cell viability (p < 0.0001), and a significant increase in oxidative stress (p < 0.0001). Furthermore, HUVECs subjected to 96 h of starvation, or exposed to concentrations of H2O2 of 400 to 1000 μM resulted in impaired angiogenic and migratory potentials. These models will enable improved physiological studies of endothelial cell dysfunction, and the rapid testing of cellular efficacy and toxicity of future novel therapeutic compounds. Full article
(This article belongs to the Special Issue Endothelial Dysfunction in Cardiopulmonary Diseases—Effects of the Micro- and Macro-Environment)
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9 pages, 1929 KiB  
Article
Experimental Setting for Applying Mechanical Stimuli to Study the Endothelial Response of Ex Vivo Vessels under Realistic Pathophysiological Environments
by Ana Osuna, Anna Ulldemolins, Hector Sanz-Fraile, Jorge Otero, Núria Farré, Ramon Farré and Isaac Almendros
Life 2021, 11(7), 671; https://doi.org/10.3390/life11070671 - 8 Jul 2021
Cited by 1 | Viewed by 2037
Abstract
This paper describes the design, construction and testing of an experimental setting, making it possible to study the endothelium under different pathophysiological conditions. This novel experimental approach allows the application of the following stimuli to an ex vivo vessel in a physiological bath: [...] Read more.
This paper describes the design, construction and testing of an experimental setting, making it possible to study the endothelium under different pathophysiological conditions. This novel experimental approach allows the application of the following stimuli to an ex vivo vessel in a physiological bath: (a) a realistic intravascular pressure waveform defined by the user; (b) shear stress in the endothelial layer since, in addition to the pressure waveform, the flow through the vessel can be independently controlled by the user; (c) conditions of hypo/hyperoxia and hypo/hypercapnia in an intravascular circulating medium. These stimuli can be applied alone or in different combinations to study possible synergistic or antagonistic effects. The setting performance is illustrated by a proof of concept in an ex vivo rabbit aorta. The experimental setting is easy to build by using very low-cost materials widely available. Online Supplement files provide all the technical information (e.g., circuits, codes, 3D printer drivers) following an open-source hardware approach for free replication. Full article
(This article belongs to the Special Issue Endothelial Dysfunction in Cardiopulmonary Diseases—Effects of the Micro- and Macro-Environment)
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