Emerging Biomarkers: Recent Findings and Application in Pathological Condition Detection—2nd Edition

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 27 September 2024 | Viewed by 847

Special Issue Editor


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Guest Editor
Department of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, 86100 Campobasso, Italy
Interests: laboratory medicine; biomarkers; metabolomics; stem cell; cystic fibrosis; neurologic diseases
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Special Issue Information

Dear Colleagues,

With the first volume of this Special Issue being a great success (https://www.mdpi.com/journal/life/special_issues/Emerging_Biomarkers), we invite you to publish your research in the second volume.

In recent years, the search for disease biomarkers has been gaining increasing attention of the scientific community, since new strategies are needed for early and accurate diagnosis, and new therapeutic approaches, as well as to identify or modify the course of several diseases. The surge of interest in biomarker research is leading to the development of new predictive, diagnostic and prognostic products in medical practice, and biomarkers are also playing an increasingly important role in the discovery and development of new drugs.

Understanding the relationship between measurable biological processes and clinical outcomes is crucial to expanding our chances of treating several diseases, and deepening our understanding of physiological conditions.

The use of biomarkers in basic and clinical research, as well as in clinical practice has become so wide that their presence as primary endpoints in clinical trials is widely accepted.

In this Special Issue, advances will be presented in the identification of reliable, sensitive, specific, non-invasive, inexpensive and easily detectable biomarkers that could provide a dynamic and powerful approach, useful in understanding the broad spectrum of the various pathologies.

All contributions from researchers dealing with the identification of biomarkers, the elucidation of their role and the formalization of their application in modern medicine are welcome.

Dr. Antonella Angiolillo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomarkers
  • biological fluids
  • early diagnosis
  • laboratory medicine

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Published Papers (1 paper)

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Review

23 pages, 3503 KiB  
Review
Endotyping Chronic Respiratory Diseases: T2 Inflammation in the United Airways Model
by Pasquale Ambrosino, Giuseppina Marcuccio, Giuseppina Raffio, Roberto Formisano, Claudio Candia, Fabio Manzo, Germano Guerra, Ennio Lubrano, Costantino Mancusi and Mauro Maniscalco
Life 2024, 14(7), 899; https://doi.org/10.3390/life14070899 - 19 Jul 2024
Viewed by 603
Abstract
Over the past 15 years, the paradigm of viewing the upper and lower airways as a unified system has progressively shifted the approach to chronic respiratory diseases (CRDs). As the global prevalence of CRDs continues to increase, it becomes evident that acknowledging the [...] Read more.
Over the past 15 years, the paradigm of viewing the upper and lower airways as a unified system has progressively shifted the approach to chronic respiratory diseases (CRDs). As the global prevalence of CRDs continues to increase, it becomes evident that acknowledging the presence of airway pathology as an integrated entity could profoundly impact healthcare resource allocation and guide the implementation of pharmacological and rehabilitation strategies. In the era of precision medicine, endotyping has emerged as another novel approach to CRDs, whereby pathologies are categorized into distinct subtypes based on specific molecular mechanisms. This has contributed to the growing acknowledgment of a group of conditions that, in both the upper and lower airways, share a common type 2 (T2) inflammatory signature. These diverse pathologies, ranging from allergic rhinitis to severe asthma, frequently coexist and share diagnostic and prognostic biomarkers, as well as therapeutic strategies targeting common molecular pathways. Thus, T2 inflammation may serve as a unifying endotypic trait for the upper and lower airways, reinforcing the practical significance of the united airways model. This review aims to summarize the literature on the role of T2 inflammation in major CRDs, emphasizing the value of common biomarkers and integrated treatment strategies targeting shared molecular mechanisms. Full article
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