The Importance of Fatty Acids in Perinatal Life

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Reproductive and Developmental Biology".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 2164

Special Issue Editor

Department of Biochemistry and Medical Chemistry, Medical School, University of Pecs, Pecs, Hungary
Interests: fatty acids; perinatal life; human milk; pregnancy; type 1 diabetes mellitus; lipids; nutrition; paediatrics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Long-chain polyunsaturated fatty acids (LCPUFAs) play a key role in the maturation of the nervous system in perinatal life, i.e., during the third trimester and after birth, in the first years of life, with an adequate fetal fatty acid supply during pregnancy provided by the maternal stores and diet. The importance of LCPUFAs in fetal life is also supported by the presence of fatty acid transfer proteins in the placenta. After birth, the exclusive fatty acid source for newborns is breast milk or, in the absence of breastfeeding, infant formulas. Maternal LCPUFAs, mainly DHA, can be greatly influenced by diet, as high levels have been observed in those who regularly consume seafood or fish. The breast milk lipid and LCPUFA content is also influenced by several factors, such as the gestational age at delivery, course of lactation, time of sampling or nationality. An adequate fatty acid (mainly DHA) supply can, therefore, affect the maturation of the infant’s nervous system, visual acuity as well as the immune system, and can also reduce the prevalence of maternal postpartum depression. The role of major LCPUFAs in the early nervous system development has been extensively researched and the importance of DHA intake is evident during this period; however, other less-researched fatty acids, such as nervonic acid or trans fatty acids, may also affect perinatal growth and development.

This Special Issue will focus on the role of different fatty acids in the perinatal life period and their possible effect on a neonatal or infant, as well as the maternal health.

Dr. Eva Szabo
Guest Editor

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Keywords

  • fatty acids
  • arachidonic acid
  • docosahexaenoic acid
  • pregnancy
  • delivery
  • newborn
  • infant
  • diet
  • nutrition
  • breastfeeding
  • human milk
  • formula feeding
  • complementary feeding
  • fetal development
  • visual acuity
  • nervous system
  • neonatal growth

Published Papers (1 paper)

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Review

19 pages, 1567 KiB  
Review
Dietary Implications of Polyunsaturated Fatty Acids during Pregnancy and in Neonates
by Emilio Herrera and Henar Ortega-Senovilla
Life 2023, 13(8), 1656; https://doi.org/10.3390/life13081656 - 29 Jul 2023
Cited by 3 | Viewed by 1507
Abstract
Certain limitations exist for animals to modify fatty acid changes. Besides the role of arachidonic acid (AA), docosahexaenoic acid (DHA) and other 20-carbon long-chain polyunsaturated fatty acids (LCPUFAs) for the synthesis of inflammatory mediators as eicosanoids, different LCPUFAs have many other effects, including [...] Read more.
Certain limitations exist for animals to modify fatty acid changes. Besides the role of arachidonic acid (AA), docosahexaenoic acid (DHA) and other 20-carbon long-chain polyunsaturated fatty acids (LCPUFAs) for the synthesis of inflammatory mediators as eicosanoids, different LCPUFAs have many other effects, including their abilities to regulate gene expression and downstream events. LCPUFAs are susceptible to autoxidation, which is prevented by the action of antioxidants in the form of enzymes like superoxide dismutases, catalases and peroxidases, as well as antioxidant compounds that protect against oxidation or repair the damage caused. Under normal conditions, the fetus needs both essential fatty acids (EFAs) and LCPUFAs, which are obtained from its mother by placental transfer. In early pregnancy, dietary derived fatty acids are accumulated in maternal adipose tissue. However, during late pregnancy, corresponding to the period of the highest fetal growth, maternal adipose tissue becomes catabolic and LCPUFAs are released into the circulation by adipose lipolytic activity. The released LCPUFAs are taken up by maternal liver to be esterified and released back to the circulation as triacylglycerides (TAGs) in very-low-density lipoprotein (VLDL) that become available to the placenta to be transferred to the fetus in the form of non-esterified fatty acids (NEFAs). An enhanced adipose tissue lipolysis is maintained around parturition and esterified LCPUFAs are diverted to mammary glands thanks to an increased activity of lipoprotein lipase for milk production. Throughout this process, LCPUFAs become available to the newborn during suckling. The important role of both DHA and AA for the development of the nervous system and for growth has motivated their dietary supplement during different postnatal stages. This has been especially important in preterm infants both because under normal conditions, the fetus acquires most of these fatty acids during late pregnancy, and because the immaturity of the enzyme systems for the synthesis of AA and DHA from their respective EFAs. Full article
(This article belongs to the Special Issue The Importance of Fatty Acids in Perinatal Life)
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