The Role of Immune Cells in Multiple Sclerosis
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Cell Biology and Tissue Engineering".
Deadline for manuscript submissions: closed (10 June 2022) | Viewed by 2228
Special Issue Editors
Interests: microglia; monocyte; multiple sclerosis
Special Issue Information
Dear Colleagues,
Multiple sclerosis (MS) is a complex chronic inflammatory demyelinating disease of the central nervous system (CNS). One of the fundamental pathomechanisms involves the activation of myelin-specific autoreactive T cells, which in turn initiate a cell- and humoral-mediated immune response in the CNS. Accordingly, past therapeutic interventions mainly focused on the depletion or blockade of lymphocytes. However, recent evidence obtained from new genetically modified animal models and high-dimensional single-cell technologies has indicated a much more complex picture of MS pathophysiology. These methodologies uncovered Th17 cells as the main pathogenic lymphocyte subset due to the release of the effector cytokine GM-CSF, which plays a critical role in the instruction of tissue-destructive monocytes. Further, dendritic cells, natural killer cells, microglia, and other immune cells have been shown to contribute to disease progression. On top of these organism-intrinsic factors, environmental parameters such as diet, fasting, and a deregulated circadian rhythm also have an effect on immune cell functions and indirectly influence the course of disease.
These data show that MS is a multifaceted disease in which more than one immune cell population is involved in tissue damage. Accordingly, in this Special Issue, we would like to collect review articles that summarize the current knowledge of immunological components of MS. Our goal is to provide the reader with a wide range of immune cell activities and how these cells influence the disease course of MS.
Dr. Alexander Mildner
Dr. Chotima Böttcher
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
