Novel Intervention Technology for Arresting Pathogen Transmission

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Epidemiology".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 1762

Special Issue Editor


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Guest Editor
Division of Environmental & Population Health Biosciences, Environmental & Occupational Health Sciences Institute (EOHSI), Rutgers University, Piscataway, NJ 08854, USA
Interests: antimicrobial technology development; nanotechnology; antibiotic resistance; high-voltage electrical discharges

Special Issue Information

Dear Colleagues,

Despite the development of a large array of antibiotics and vaccines, infectious diseases continue to affect hundreds of millions of people each year with serious outcomes, impacting public health adversely. Incorrect prescription of antibiotics and their overuse has led to the most dangerous rise in antibiotic resistance. Developing newer classes of antibiotics is an arduous and costly process, often taking years. Recently, the COVID-19 pandemic caused by the SARS-CoV-2 coronavirus has underscored the threat of emerging viral infections. In a highly interconnected world, the ease with which a virus such as SARS-CoV-2 has spread, leading to a global crisis, is highly alarming. The rapid spread of these pathogens is mostly through surface contamination and aerosol droplets. A major avenue for arresting the spread of these deadly pathogens is through non-clinical intervention technologies that inactivate the microbes in the environment, i.e., on surfaces and in the air. There is a vital need to develop novel technologies to tackle potentially antibiotic-resistant pathogens and novel viruses that might emerge.

In this Special Issue, we would like to highlight the cutting-edge research currently being carried out at the forefront of the battle against these pathogens. We invite high-quality research studies detailing the development of effective antimicrobial intervention technologies against surface and aerosol transmission. The scope of this issue consists of the following:

  • Ultraviolet and light-based technologies;
  • Nanotechnology-based intervention methods;
  • High pressure and thermal methods;
  • Electrical discharge-based and microwave devices.

We look forward to featuring your exciting research in this field, which would be of great interest to the readers of the journal and the broad scientific community in general. Thank you.

Dr. Nachiket Vaze
Guest Editor

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Keywords

  • fomites
  • ultraviolet disinfection
  • bioaerosol transmission
  • air disinfection
  • antimicrobial intervention technologies

Published Papers (1 paper)

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Research

10 pages, 1231 KiB  
Article
Comparative Assessment of Pulsed and Continuous LED UV-A Lighting for Disinfection of Contaminated Surfaces
by Erik Kvam, Brian Davis and Kevin Benner
Life 2022, 12(11), 1747; https://doi.org/10.3390/life12111747 - 31 Oct 2022
Cited by 4 | Viewed by 1458
Abstract
The germicidal efficacy of LED UV-A lighting has scarcely been compared in continuous and pulsed modes for contaminated surfaces. Herein, we compare the disinfection properties of pulsed versus continuous lighting at equal irradiances using a 365 nm LED device that replicates the doses [...] Read more.
The germicidal efficacy of LED UV-A lighting has scarcely been compared in continuous and pulsed modes for contaminated surfaces. Herein, we compare the disinfection properties of pulsed versus continuous lighting at equal irradiances using a 365 nm LED device that replicates the doses of occupied-space continuous disinfection UV-A products. Representative organisms evaluated in this study included human-infectious enveloped and non-enveloped viruses (lentivirus and adeno-associated virus, respectively), a bacterial endospore (Bacillus atrophaeus), and a resilient gram-positive bacterium (Enterococcus faecalis). Nominal UV-A irradiances were tested at or below the UL standard limit for continuous human exposure (maximum irradiance of 10 W/m2). We observed photoinactivation properties that varied by organism type, with bacteria and enveloped virus being more susceptible to UV-A than non-enveloped virus and spores. Overall, we conclude that continuous-mode UV-A lighting is better suited for occupied-space disinfection than pulsing UV-A at equivalent low irradiances, and we draw comparisons to other studies in the literature. Full article
(This article belongs to the Special Issue Novel Intervention Technology for Arresting Pathogen Transmission)
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