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Life
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Urological Dysfunction: State of the Art
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Urological Dysfunction: State of the Art

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: closed (8 July 2022) | Viewed by 14675

Special Issue Editors

Dr. Giovanni Palleschi

E-Mail Website
Guest Editor
Medica San Carlo – Nephrology & Dialysis Center, 00044 Frascati, Italy
Interests: neurourology; bladder outlet obstruction; urinary incontinence
Dr. Mario Falsaperla

E-Mail Website
Guest Editor
Chairman Department of Urology, ARNAS (Healtcare Conpany of National Relief and High Specialization) Garibaldi of Catania, 95123 Catania, Italy
Interests: benign prostate hyperplasia; bladder outlet obstruction; chronic urinary retention

Special Issue Information

Dear Colleagues,

It is a pleasure for me to invite you to support this project aiming to publish a Special Issue on the State of the Art of Urological Dysfunction. We will collect a series of topics resuming the most recent data about knowledge on the pathophysiology and therapy of urological dysfunctions. Most urological pathologies have a dysfunctional origin; the depth of knowledge on the pathophysiology that underlies them has today allowed the availability of excellent therapeutical strategies. On the other hand, in the uro-oncological field, surgery is often characterized by important functional changes that often result in complications, decreasing quality of life. In this work, we will be able to set up an update on the current pathophysiological knowledge of urological dysfunctions, both primary and consequent to surgical acts, and their treatment aspects.

Dr. Giovanni Palleschi
Dr. Mario Falsaperla
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bladder outlet obstruction
  • urinary incontinence
  • chronic urinary retention
  • urological dysfunction

Published Papers (4 papers)

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Research

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11 pages, 461 KiB  
Article
The Occurrence of Nephrolithiasis in Gout Patients: A Longitudinal Follow-Up Study Using a National Health Screening Cohort
by So Young Kim, Dae Myoung Yoo, Ji Hee Kim, Mi Jung Kwon, Joo-Hee Kim, Jung Woo Lee, Woo Jin Bang and Hyo Geun Choi
Life 2022, 12(5), 653; https://doi.org/10.3390/life12050653 - 28 Apr 2022
Viewed by 1941
Abstract
The association of gout with nephrolithiasis has been suggested. The current study investigated the risk of nephrolithiasis in patients with gout. The relationship of nephrolithiasis with gout was assessed according to patient characteristics. Individuals in the Korean National Health Insurance Service–Health Screening Cohort [...] Read more.
The association of gout with nephrolithiasis has been suggested. The current study investigated the risk of nephrolithiasis in patients with gout. The relationship of nephrolithiasis with gout was assessed according to patient characteristics. Individuals in the Korean National Health Insurance Service–Health Screening Cohort were examined. The 17,043 participants with gout were paired with 68,172 comparison participants. The diagnosis of nephrolithiasis was examined in both the gout and control groups. The possible risk of nephrolithiasis in the gout group was analyzed using a stratified Cox proportional hazards model. Subcategory analyses were conducted according to demographic features and comorbidities. The rate of nephrolithiasis was 3.3% (569/17,043) in the gout group and 2.6% (1786/68,172) in the control group. The adjusted hazard ratio (aHR) of gout for nephrolithiasis was 1.23 (95% confidence intervals [95% CI] = 1.12–1.36) in the overall study population. The < 60 years and male groups showed an increased risk of nephrolithiasis related to gout (aHR = 1.26 [1.13–1.42] for the < 60 years group; aHR = 1.27 [1.15–1.41] for the male group). Regarding comorbidities, all subgroups except for the underweight, overweight, total cholesterol ≥ 240 mg/dL, fasting blood glucose ≥ 100 mg/dL, and CCI score 1 and ≥ 2 groups showed a higher risk of nephrolithiasis in gout patients. The gout patients presented an increased occurrence of nephrolithiasis. The middle-aged, male, and healthy populations showed consistently higher HRs of nephrolithiasis related to gout. Full article
(This article belongs to the Special Issue Urological Dysfunction: State of the Art)
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Review

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12 pages, 897 KiB  
Review
Stem Cell Therapy for Erectile Dysfunction: A Step towards a Future Treatment
by Xabier Pérez-Aizpurua, María Garranzo-Ibarrola, Carlos Simón-Rodríguez, Juan Vicente García-Cardoso, César Chávez-Roa, Leticia López-Martín, Jaime Jorge Tufet i Jaumot, Josué Alonso-Román, Jesús Maqueda-Arellano, Blanca Gómez-Jordana, Joaquín Ruiz de Castroviejo-Blanco, Felipe Osorio-Ospina, Carmen González-Enguita and Mariano García-Arranz
Life 2023, 13(2), 502; https://doi.org/10.3390/life13020502 - 11 Feb 2023
Cited by 3 | Viewed by 4374
Abstract
Background: The improvement of absent or partial response in the medical treatment of erectile dysfunction (ED) has led to the development of minimally invasive new treatment modalities in the field of regenerative medicine. Methods: A literature review on stem cell therapy [...] Read more.
Background: The improvement of absent or partial response in the medical treatment of erectile dysfunction (ED) has led to the development of minimally invasive new treatment modalities in the field of regenerative medicine. Methods: A literature review on stem cell therapy for the treatment of ED was performed. We searched for the terms “erectile dysfunction” and “stem cell therapy” in PubMed and Clinicaltrials.gov. Literature searching was conducted in English and included articles from 2010 to 2022. Results: New treatment modalities for ED involving stem cell therapy are not only conceived with a curative intent but also aim to avoid unnecessary adverse effects. Several sources of stem cells have been described, each with unique characteristics and potential applications, and different delivery methods have been explored. A limited number of interventional studies over the past recent years have provided evidence of a safety profile in their use and promising results for the treatment of ED, although there are not enough studies to generate an appropriate protocol, dose or cell lineage, or to determine a mechanism of action. Conclusions: Stem cell therapy is a novel treatment for ED with potential future applications. However, most urological societies agree that further research is required to conclusively prove its potential benefit. Full article
(This article belongs to the Special Issue Urological Dysfunction: State of the Art)
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17 pages, 375 KiB  
Review
Neobladder “Function”: Tips and Tricks for Surgery and Postoperative Management
by Daniela Fasanella, Michele Marchioni, Luigi Domanico, Claudia Franzini, Antonino Inferrera, Luigi Schips and Francesco Greco
Life 2022, 12(8), 1193; https://doi.org/10.3390/life12081193 - 4 Aug 2022
Cited by 6 | Viewed by 3643
Abstract
Orthotopic neobladder (ONB) reconstruction is a continent urinary diversion procedure increasingly used in patients with muscle-invasive bladder cancer following radical cystectomy (RC). It represents a valid alternative to the ileal duct in suitable patients who do not prefer a stoma and are motivated [...] Read more.
Orthotopic neobladder (ONB) reconstruction is a continent urinary diversion procedure increasingly used in patients with muscle-invasive bladder cancer following radical cystectomy (RC). It represents a valid alternative to the ileal duct in suitable patients who do not prefer a stoma and are motivated to undergo adequate training of the neobladder. Careful patient selection, taking into account the absolute and relative contraindications for ONB as well as an adequate recovery protocol after surgery are integral to the success of this procedure and the oncological and functional outcomes. The objective of this review is to summarize the current data on RC with ONB in terms of patient selection, preoperative preparation, surgical techniques and functional (continence and sexual activity) and oncological outcomes, with particular attention to the management of complications and the impact on quality of life (QoL). Full article
(This article belongs to the Special Issue Urological Dysfunction: State of the Art)

Other

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6 pages, 916 KiB  
Case Report
Extraperitoneal Laparoscopic Prostatectomy in a Prostate Cancer Patient Undergoing Continuous Ambulatory Peritoneal Dialysis
by Damian Widz, Iga Kuliniec, Andriy Yadlos, Damian Sudoł, Michał Godzisz, Agata Wisz, Paweł Płaza, Przemysław Mitura, Michał Cabanek and Krzysztof Bar
Life 2022, 12(3), 413; https://doi.org/10.3390/life12030413 - 12 Mar 2022
Viewed by 4161
Abstract
Radical prostatectomy (RP) in patients on continuous ambulatory peritoneal dialysis (CAPD) is a challenging procedure. The following key points need to be considered: the peritoneal cavity integrity, adjustment of the trocar positions to the peritoneal dialysis (PD) tube location, and the oncological and [...] Read more.
Radical prostatectomy (RP) in patients on continuous ambulatory peritoneal dialysis (CAPD) is a challenging procedure. The following key points need to be considered: the peritoneal cavity integrity, adjustment of the trocar positions to the peritoneal dialysis (PD) tube location, and the oncological and functional outcomes. We present a clinical case of a patient on CAPD, incidentally diagnosed with prostate cancer (PCa) during the pre-transplant evaluation. The patient suffered from LUTS, due to bladder outlet obstruction (BOO). A transurethral bladder neck incision (TUNI), with median lobe resection, was performed. A PCa Gleason score of six (3 + 3) was found in the histopathological specimen. The primary procedure was complicated by bladder neck sclerosis and acute urinary retention (AUR), resolved by suprapubic cystostomy. After proper staging determination, the patient was qualified for laparoscopic extraperitoneal RP. The standard trocar placement was modified to align with the route of the PD tube, and Retzius’ space scarring was released to allow extraperitoneal prostatectomy. There were no signs of peritoneal wall damage or dialysis tube displacement. Peritoneal dialysis was resumed after 4 weeks. Laparoscopic extraperitoneal RP should be considered as an acceptable treatment method for selected patients with localized prostate cancer, allowing CAPD resumption. To the best of our knowledge, this is the first report of retroperitoneal laparoscopic RP being used in the PD population. Full article
(This article belongs to the Special Issue Urological Dysfunction: State of the Art)
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