Clinical Management and Prevention of Adverse Pregnancy Outcomes

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Reproductive and Developmental Biology".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 776

Special Issue Editors


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Guest Editor
Capio Specialized Center for Gynecology, 171 45 Solna, Sweden
Interests: molecular, ultrasound and clinical characterization of pregnancy complications; placental histology
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Guest Editor
Department of Obstetrics and Gynecology, University of Szeged, 6725 Szeged, Hungary
Interests: perinatal ultrasound; serum markers for complications of pregnancy; histopathology of the placenta; neonatal pathological conditions
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The clinical characteristics of various pregnancy complications are pivotal to prevent maternal and neonatal morbidity and mortality. Molecular, sonographic and clinical screening are essential to optimize the management of complicated pregnancies. Pre-eclampsia and gestational diabetes are among the most common complications and are unique to humans. Chronic diseases also represent risk for fetoplacental development. Therapeutic strategies completed with novel screening methods help augment early screening during gestation. Significant advances can be provided in the prediction and prevention of preterm birth if multiple risk factors can be identified. Increasing evidence points to the substantial role of genetic, immunologic and other fetoplacental development-related factor levels in screening for pregnancy outcomes. Cytogenetic and molecular mapping are identified as a useful tool in almost every complication of pregnancies, and even in stillbirth. Gestational diseases (such as gestational diabetes mellitus or intrahepatic cholestasis) are a growing public health problem worldwide, and nutrigenetic and epigenetic characterization may decrease the short- and long-term complications for both mother and offspring. Pregnancy affected by any complication might have a transgenerational effect. Inventing additional screening specifics may help us to better understand the clinical course of pregnancies and chronic pathologies, and avoid adverse outcomes.

Dr. Zoltan Kozinszky
Dr. Andrea Suranyi
Guest Editors

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Keywords

  • pathologic pregnancies
  • ultrasound
  • clinical and molecular characteristics
  • fetal pathologies

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Published Papers (1 paper)

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9 pages, 1730 KiB  
Case Report
Multidisciplinary Approach in the Diagnosis and Treatment of Twin Anemia Polycythemia Sequence in Monochorionic Twin Pregnancies: Case Report
by Marina Fortún Agud, María Marfil González, Susana Monis Rodríguez, Maria Suarez Arana, Marta Blasco Alonso, Jesus Jimenez Lopez and Isidoro Narbona Arias
Life 2024, 14(9), 1071; https://doi.org/10.3390/life14091071 - 27 Aug 2024
Viewed by 507
Abstract
Twin anemia–polycythemia sequence (TAPS) in monochorionic twin pregnancies is a potentially serious complication caused by unidirectional vascular anastomoses in the placenta, resulting in one anemic donor twin and one polycythemic recipient twin. Diagnosis of this condition is achieved through Doppler ultrasound assessment of [...] Read more.
Twin anemia–polycythemia sequence (TAPS) in monochorionic twin pregnancies is a potentially serious complication caused by unidirectional vascular anastomoses in the placenta, resulting in one anemic donor twin and one polycythemic recipient twin. Diagnosis of this condition is achieved through Doppler ultrasound assessment of the difference between the MoM of the peak systolic velocity of the middle cerebral artery between the twins, establishing the diagnosis with a delta value >0.5 MoM. Management of this situation is individualized and may include intrauterine transfusions, intrauterine laser treatment, and expectant management through ultrasound monitoring of both fetuses to prevent complications. In severe cases, pregnancy termination may be necessary. It is essential that these pregnancies are managed by a multidisciplinary team of professionals, including obstetricians specialized in fetal medicine and neonatologists, to ensure the best possible outcome for both the mother and the fetuses. Early detection and treatment are crucial in the management of pregnancies complicated by twin anemia–polycythemia sequence. The main objective of this article is to conduct a review of the existing literature on the anemia–polycythemia sequence in monochorionic pregnancies, emphasizing the exceptional nature of the presented case due to its spontaneous occurrence, which has a very low prevalence compared to post-laser TAPS cases. It also discusses the different treatment options, highlighting the importance of expectant management and individualization in each case. Full article
(This article belongs to the Special Issue Clinical Management and Prevention of Adverse Pregnancy Outcomes)
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