New Advances in Retinal Research: Basic, Clinical and Translational Approaches
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 3183
Special Issue Editors
2. Biosanitary Research Institute of Murcia-Virgen de la Arrixaca (IMIB-Arrixaca), C/ Campo, 12, El Palmar, 30120 Murcia, Spain
Interests: retina; retinal degeneration; retinal diseases; retinal ganglion cells; eyes; photoreceptor cells; eye diseases; taurine; contact lenses; dry eye; myopia control; optometry
Special Issues, Collections and Topics in MDPI journals
2. Department of Immunology, Ophthalmology and ENT, Faculty of Optics and Optometry, Complutense University of Madrid, 28040 Madrid, Spain
Interests: neurodegeneration; retina; Alzheimer’s; glaucoma; ALS; microglia; astrocytes; retinal ganglion cells; Müller cells; optical coherence tomography; optometry; ophthalmology
Interests: retinal ganglion cells; melanopsin; optic nerve; ocular hypertension; axotomy; photoreceptors; phototoxicity; microglia
Special Issue Information
Dear Colleagues,
The great value of the retina as a “genuine neural center” was recognized a century ago by the Spanish neuroscientist Santiago Ramón y Cajal. As part of the central nervous system, the retina is a window to the brain that provides an excellent and accessible tissue for detailed anatomical, physiological and pharmacological research. In addition, the easy in vivo observation of the retinal structure and its vascular network provides insight into the progress of pathologies that are not specific to the eye, such as neurodegenerative diseases including Alzheimer's, amyotrophic lateral sclerosis, Friedreich ataxia, and diabetes.
Retinal research is currently dealing with major causes of blindness, including some untreatable retinal diseases. Among them, retinal degenerative diseases represent one of the greatest challenges, as they lead to irreversible blindness. In recent years, researchers have proposed different therapeutic options that include therapies aimed at halting or slowing retinal degeneration such as neurotrophic factors; antiapoptotic, antioxidant or anti-inflammatory drugs; and therapies aimed at photoreceptor replacement such as stem-cell therapies and photoreceptor or retinal prosthetic transplants. However, there is currently no existing effective treatment capable of preventing, restoring or reversing retinal degeneration or, ultimately, preventing or reversing the devastating effects of retinal remodeling following photoreceptor loss. Furthermore, functional studies could, to a certain extent, allow us to predict or anticipate irreversible damage such as electroretinographic or visual-field defects in glaucoma patients with damage to the retinal ganglion cell axons that form the optic nerve. All of the above make retinal research an exciting field of study that deserves our full attention.
The present Special Issue, edited by Dr. García-Ayuso, Dr. Salobrar-García and Dr. Valiente-Soriano, will focus on the latest advances in retinal research, including basic, translational and clinical sciences, with the purpose of expanding the therapeutic perspective of retinal degeneration as well as the impact that certain systemic diseases can have on the retina.
Authors are cordially invited to contribute original research papers or reviews to this Special Issue of Life.
Dr. Diego García-Ayuso
Dr. Elena Salobrar-García
Dr. Francisco Javier Valiente-Soriano
Guest Editors
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Keywords
- Photoreceptor degeneration
- Inherited retinal degeneration
- Glaucoma
- Retinal ganglion cells
- Melanopsin
- Phototoxicity
- Alzheimer´s disease
- Neurodegeneration
- Neuroprotection
- Stem cells
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