Viral Subversion of Host Cell Biochemical and Structural Architecture

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Epidemiology".

Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 9066

Special Issue Editor


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Guest Editor
National Center for Advancing Translational Sciences (NCATS), Rockville, MD 20852, USA
Interests: COVID-19; Ebola; Zika; fluorescent biosensors; high-content imaging; high-throughput screening; fluorescence microscopy; phenotypic profiling; cell biology; in vitro models; pharmacology; drug discovery; neuropharmacology

Special Issue Information

Dear Colleagues,

It is well known that viruses use host cells to propagate. What is less understood are the mechanisms by which viruses and cells interact. New information about how viruses use subcellular machinery in various parts of the viral life-cycle is being discovered every day. Uncovering the viral utilization of host cell biochemical and structural architecture is important for battling viral pandemics now and in the future. This topic will include articles describing viral–host interactions with emphasis on biochemical signaling pathways, subcellular compartmentalization, viral structural organization, and cellular structure as it relates to viral infection and replication. Studies concerning post-translational modifications of host and viral proteins, mechanisms of viral cytopathic effect compared to viral replication without cell death, and differences between tissue and cell-type infectivity are also acceptable in the context of biochemical and structural architectures of the cell. Translational applications of such research to drug discovery can be included. Studies pertaining to the current SARS-CoV-2 pandemic and the resulting COVID-19 will be prioritized.

Dr. Kirill Gorshkov
Guest Editor

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Keywords

  • viruses

Published Papers (1 paper)

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Review

25 pages, 20143 KiB  
Review
Flavivirus: From Structure to Therapeutics Development
by Rong Zhao, Meiyue Wang, Jing Cao, Jing Shen, Xin Zhou, Deping Wang and Jimin Cao
Life 2021, 11(7), 615; https://doi.org/10.3390/life11070615 - 25 Jun 2021
Cited by 27 | Viewed by 7814
Abstract
Flaviviruses are still a hidden threat to global human safety, as we are reminded by recent reports of dengue virus infections in Singapore and African-lineage-like Zika virus infections in Brazil. Therapeutic drugs or vaccines for flavivirus infections are in urgent need but are [...] Read more.
Flaviviruses are still a hidden threat to global human safety, as we are reminded by recent reports of dengue virus infections in Singapore and African-lineage-like Zika virus infections in Brazil. Therapeutic drugs or vaccines for flavivirus infections are in urgent need but are not well developed. The Flaviviridae family comprises a large group of enveloped viruses with a single-strand RNA genome of positive polarity. The genome of flavivirus encodes ten proteins, and each of them plays a different and important role in viral infection. In this review, we briefly summarized the major information of flavivirus and further introduced some strategies for the design and development of vaccines and anti-flavivirus compound drugs based on the structure of the viral proteins. There is no doubt that in the past few years, studies of antiviral drugs have achieved solid progress based on better understanding of the flavivirus biology. However, currently, there are no fully effective antiviral drugs or vaccines for most flaviviruses. We hope that this review may provide useful information for future development of anti-flavivirus drugs and vaccines. Full article
(This article belongs to the Special Issue Viral Subversion of Host Cell Biochemical and Structural Architecture)
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