Recent Trends in Carbohydrate-Based Therapeutics

A special issue of Macromol (ISSN 2673-6209).

Deadline for manuscript submissions: 30 September 2025 | Viewed by 1421

Special Issue Editor


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Guest Editor
Department of Chemistry, University of Florida, Gainesville, FL 32611, USA
Interests: glycoconjugates; glycoconjgate cancer vaccines; vaccine adjuvants; complex carbohydrate synthesis; glycosphingolipids; glycolipilds; organic chemistry

Special Issue Information

Dear Colleagues,

Carbohydrates are widely found in a variety of plants, animals, and microorganisms. Their essential biological roles have been well established. Carbohydrates are encountered in many applications across diverse fields, including glycobiology, pharmaceuticals, genetics, material chemistry, polymer chemistry, and the food industry. Particularly in medicine and advanced therapeutics, carbohydrates serve as key components. It is now recognized that carbohydrate molecules play a crucial role in various diseases, including lysosomal storage diseases, diabetes (iminosugars), cancers, Alzheimer’s disease, autoimmune diseases, and bacterial and infectious diseases. Carbohydrates demonstrate significant potential for the future of therapeutic development and have gained a central role in many therapeutic applications. Many efforts have been devoted to developing advanced and effective carbohydrate-based therapeutics for human health. Numerous carbohydrate-based drugs have received approval worldwide in this discipline, among the more than 200 drugs approved in recent decades. This Special Issue highlights recent advancements in carbohydrate-based therapeutics. It aims to engage researchers interested in developing innovative diagnostic tools, drug delivery systems, and treatments for various infectious diseases. It provides information on the growing importance of carbohydrates in fields such as chemical biology, medicinal chemistry, and materials science. We invite contributions from experts in different areas of carbohydrates. This issue explores sophisticated views on carbohydrate-based molecular scaffolding and its significance in fields such as medicinal chemistry, chemical biology, immunology, and glycomaterials.

Dr. Rajendra Rohokale
Guest Editor

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Keywords

  • glycobiology
  • chemical biology
  • immunotherapy
  • carbohydrates
  • drug discovery
  • drug design
  • glycoconjugates
  • vaccines
  • drug delivery

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Published Papers (1 paper)

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Research

17 pages, 2194 KiB  
Article
Polysaccharides from Brown Seaweeds (Padina boergesenii and Sargassum euryphyllum) as Promising Inhibitors of SARS-CoV-2: Characterization, Mechanisms, and Therapeutic Potential
by Saly Gheda, Ali M. Karkour, Shimaa El Shafay, Mohamed GabAllah, João Cotas and Leonel Pereira
Macromol 2025, 5(2), 18; https://doi.org/10.3390/macromol5020018 - 10 Apr 2025
Viewed by 964
Abstract
Unexpected mutations in SARS-CoV-2 produce unique variations. While numerous vaccines and antiviral medications are available for SARS-CoV-2, their use in controlling and preventing COVID-19 is restricted in some areas and countries due to accessibility and cost issues. This study investigated polysaccharides produced from [...] Read more.
Unexpected mutations in SARS-CoV-2 produce unique variations. While numerous vaccines and antiviral medications are available for SARS-CoV-2, their use in controlling and preventing COVID-19 is restricted in some areas and countries due to accessibility and cost issues. This study investigated polysaccharides produced from two brown seaweed (Padina boergesenii and Sargassum euryphyllum) for their capacity to inhibit SARS-CoV-2. The seaweed polysaccharides were characterized and identified using ultraviolet and visible (UV/VIS) and Fourier transform infrared attenuated total reflectance (FTIR-ATR) spectra. The polysaccharides inhibited SARS-CoV-2 propagation with inhibitory concentration 50% (IC50) values ranging from 24.2 to 29.3 µg/mL and cytotoxicity concentration 50% (CC50) values for Vero-E6 cells ranging from 587.7 to 396.4 µg/mL for P. boergesenii and S. euryphyllum, respectively. P. boergesenii polysaccharide had a more substantial antiviral potential than S. euryphyllum against SARS-CoV-2 and appeared more promising. At a concentration of 575 µL/mL of P. boergesenii polysaccharide, the virucidal mechanism was found to be the most effective, followed by viral adsorption and replication, with viral inhibition percentages of 68.6% ± 0.8, 57.1% ± 1.4, and 37.2 ± 3, respectively, compared to remdesivir as an antiviral drug. Thus, we concluded that brown seaweed alginate polysaccharides efficiently inhibit SARS-CoV-2 from spreading by preventing viral entry. Finally, P. boergesenii polysaccharide looked promising as a potential therapeutic candidate for the treatment of COVID-19. Full article
(This article belongs to the Special Issue Recent Trends in Carbohydrate-Based Therapeutics)
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