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Magnetochemistry
Special Issues
Applications of Magnetic Materials in Medicine: Knowledge and Perspectives
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Applications of Magnetic Materials in Medicine: Knowledge and Perspectives

A special issue of Magnetochemistry (ISSN 2312-7481). This special issue belongs to the section "Magnetic Materials".

Deadline for manuscript submissions: closed (20 November 2022) | Viewed by 11219

Special Issue Editor

Prof. Dr. Redha Taiar

E-Mail Website
Guest Editor
Department of Physical Education and Sports (EPS), University of Reims Champagne-Ardenne, Reims, France
Interests: biomechanics of health disease and rehabilitation; industry engineering for medicine and high-level sport
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The effectiveness of biological systems can be very complex, requiring a visible interaction between the physical sciences (metrology), sciences and technologies of information and sciences of life (materials, fabrics, organs and members).

The purpose of this Special Issue is to define and understand the latest research regarding the utilization of magnetic particles and their ability to carry data, permitting the comprehension and improvement of human behavior, with the main aim to explore and understand biological problems in medicine.

We encourage papers promoting the latest research concerning the field of magnetic material applications in medicine and providing recommendations. In fact, magnetic particles (MPs) have proved to be valuable tools for the manipulation of cells or biomolecules, for the transportation of chemical substances, the transfer of energy to defined target sites in biological systems and for clinical diagnostics and therapeutics—both in vitro as well as in vivo.

We hope to help prevent functional decline and frailty following a life-course perspective approach through the utilization of the latest research showing the importance of the application of magnetic materials in humans and their applications targeted at all stages of life aimed at the prevention, performance improvement and management of diseases.

Prof. Dr. Redha Taiar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Magnetochemistry is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • health
  • human behavior
  • engineering of magnetic materials
  • disorders
  • medicine
  • molecular magnetism
  • magnetic nanostructures
  • magnetic recording
  • theoretical models and calculations
  • applications of magnetic materials

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Published Papers (4 papers)

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Research

17 pages, 13138 KiB  
Article
Doxorubicin-Loaded Magnetic Nanoparticles: Enhancement of Doxorubicin’s Effect on Breast Cancer Cells (MCF-7)
by Elisa Parcero Hernandes, Raquel Dosciatti Bini, Karina Midori Endo, Verci Alves de Oliveira Junior, Igor Vivian de Almeida, Gustavo Sanguino Dias, Ivair Aparecido dos Santos, Paula Nunes de Oliveira, Veronica Elisa Pimenta Vicentini and Luiz Fernando Cotica
Magnetochemistry 2022, 8(10), 114; https://doi.org/10.3390/magnetochemistry8100114 - 23 Sep 2022
Cited by 10 | Viewed by 2603
Abstract
The incidence of female breast cancer has increased; it is the most commonly diagnosed cancer, at 11.7% of the total, and has the fourth highest cancer-related mortality. Magnetic nanoparticles have been used as carriers to improve selectivity and to decrease the side effects [...] Read more.
The incidence of female breast cancer has increased; it is the most commonly diagnosed cancer, at 11.7% of the total, and has the fourth highest cancer-related mortality. Magnetic nanoparticles have been used as carriers to improve selectivity and to decrease the side effects on healthy tissues in cancer treatment. Iron oxide (mainly magnetite, Fe3O4), which presents a low toxicity profile and superparamagnetic behavior, has attractive characteristics for this type of application in biological systems. In this article, synthesis and characterization of magnetite (NP-Fe3O4) and silica-coated magnetite (NP-Fe3O4/SiO2) nanoparticles, as well as their biocompatibility via cellular toxicity tests in terms of cell viability, are carefully investigated. MCF-7 cells, which are commonly applied as a model in cancer research, are used in order to define prognosis and treatment specifics at a molecular level. In addition, HaCaT cells (immortalized human keratinocytes) are tested, as they are normal, healthy cells that have been used extensively to study biocompatibility. The results provide insight into the applicability of these magnetic nanoparticles as a drug carrier system. The cytotoxicity of nanoparticles in breast adenocarcinoma (MCF-7) and HaCat cells was evaluated, and both nanoparticles, NP-Fe3O4/SiO2 and NP-Fe3O4, show high cell viability (non-cytotoxicity). After loading the anti-tumor drug doxorubicin (Dox) on NP-Fe3O4/Dox and NP-Fe3O4/SiO2/Dox, the cytotoxicity against MCF-7 cells increases in a dose-dependent and time-dependent manner at concentrations of 5 and 10 μg/mL. HaCat cells also show a decrease in cell viability; however, cytotoxicity was less than that found in the cancer cell line. This study shows the biocompatibility of NP-Fe3O4/SiO2 and NP-Fe3O4, highlighting the importance of silica coating on magnetic nanoparticles and reinforcing the possibility of their use as a drug carrier system against breast adenocarcinoma cells (MCF-7). Full article
(This article belongs to the Special Issue Applications of Magnetic Materials in Medicine: Knowledge and Perspectives)
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11 pages, 3564 KiB  
Article
Ferromagnetic Coupling and Single-Ion Magnet Phenomenon in Mononuclear Ruthenium(III) Complexes Based on Guanine Nucleobase
by Marta Orts-Arroyo, Nicolás Moliner, Francesc Lloret and José Martínez-Lillo
Magnetochemistry 2022, 8(8), 93; https://doi.org/10.3390/magnetochemistry8080093 - 17 Aug 2022
Cited by 2 | Viewed by 1972
Abstract
Two mononuclear RuIII complexes of formula trans-[RuCl4(Hgua)(dmso)]·2H2O (1) and trans-[RuCl4(Hgua)(gua)]·3H2O (2) [Hgua = protonated guanine (gua), dmso = dimethyl sulfoxide] have been synthesized and characterized magnetostructurally. 1 and [...] Read more.
Two mononuclear RuIII complexes of formula trans-[RuCl4(Hgua)(dmso)]·2H2O (1) and trans-[RuCl4(Hgua)(gua)]·3H2O (2) [Hgua = protonated guanine (gua), dmso = dimethyl sulfoxide] have been synthesized and characterized magnetostructurally. 1 and 2 crystallize in the monoclinic system with space groups P21/n and Pc, respectively. Each RuIII ion in 1 and 2 is bonded to four chloride ions and one (1) or two (2) nitrogen atoms from guanine molecules and one sulfur atom (1) of a dmso solvent molecule, generating axially compressed octahedral geometries in both cases. In their crystal packing, the RuIII complexes are connected through an extended network of N-H⋯Cl hydrogen bonds and π⋯Cl intermolecular interactions, forming novel supramolecular structures of this paramagnetic 4d ion. Variable-temperature dc magnetic susceptibility data were obtained from polycrystalline samples of 1 and 2 and their plots show a different magnetic behavior. While 1 is a ferromagnetic compound at low temperature, 2 exhibits a behavior of magnetically isolated mononuclear RuIII complexes with S = 1/2. The study on ac magnetic susceptibility data reveal slow relaxation of the magnetization, when external dc fields are applied, only for 2. These results highlight the presence of field-induced single-ion magnet (SIM) behavior for this mononuclear guanine-based RuIII complex. Full article
(This article belongs to the Special Issue Applications of Magnetic Materials in Medicine: Knowledge and Perspectives)
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23 pages, 8116 KiB  
Article
Titan Yellow and Congo Red Removal with Superparamagnetic Iron-Oxide-Based Nanoparticles Doped with Zinc
by Paulina Pietrzyk, Nguyen Thu Phuong, Sunday Joseph Olusegun, Nguyen Hong Nam, Dinh Thi Mai Thanh, Michael Giersig, Paweł Krysiński and Magdalena Osial
Magnetochemistry 2022, 8(8), 91; https://doi.org/10.3390/magnetochemistry8080091 - 14 Aug 2022
Cited by 18 | Viewed by 3095
Abstract
In this work, we present magnetic nanoparticles based on iron oxide doped with zinc synthesized using the wet co-precipitation method for environmental application. The morphology of the samples was revealed by SEM and TEM, which showed particles of granular shape and size of [...] Read more.
In this work, we present magnetic nanoparticles based on iron oxide doped with zinc synthesized using the wet co-precipitation method for environmental application. The morphology of the samples was revealed by SEM and TEM, which showed particles of granular shape and size of about 15 nm. The specific surface areas of the materials using the BET method were within the range of 85.7 to 101.5 m2 g−1 depending on the zinc content in the superparamagnetic iron oxide nanoparticles (SPIONs). Magnetometry was performed to determine the magnetic properties of the particles, indicating superparamagnetism. Synthesized magnetic nanoparticles with different amounts of zinc dopant were used as an adsorbent to remove model pollutant Titan yellow (TY) from the aqueous solutions. Adsorption was determined by investigating the effects of sorbent amount, dye concentration, and contact time. The synthesized material removed Titan yellow quickly and efficiently within the physical adsorption. The adsorption isotherms were consistent with the models proposed by Langmuir and Redlich-Peterson. The monolayer adsorption capacities were 30 and 43 mg g−1 for Fe3O4 and Fe3O4@10%Zn, respectively, for the removal of TY. However, that of Congo red is 59 mg g−1 by Fe3O4@10%Zn. The proposed nanoparticles offer fast and cost-effective water purification, and they can be separated from solution using magnets. Full article
(This article belongs to the Special Issue Applications of Magnetic Materials in Medicine: Knowledge and Perspectives)
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17 pages, 10707 KiB  
Article
Influence of Experimental Conditions during Synthesis on the Physicochemical Properties of the SPION/Hydroxyapatite Nanocomposite for Magnetic Hyperthermia Application
by Dinh Thi Mai Thanh, Nguyen Thu Phuong, Do Thi Hai, Ha Ngan Giang, Nguyen Thi Thom, Pham Thi Nam, Nguyen Trung Dung, Michael Giersig and Magdalena Osial
Magnetochemistry 2022, 8(8), 90; https://doi.org/10.3390/magnetochemistry8080090 - 12 Aug 2022
Cited by 9 | Viewed by 2608
Abstract
In this work, we report on the fabrication of nanocomposites based on superparamagnetic iron oxide nanoparticles (SPIONs) in combination with hydroxyapatite (HAp) as a platform for drug delivery and magnetic hyperthermia application. First, the influence of experimental conditions such as co-precipitant, bath temperature, [...] Read more.
In this work, we report on the fabrication of nanocomposites based on superparamagnetic iron oxide nanoparticles (SPIONs) in combination with hydroxyapatite (HAp) as a platform for drug delivery and magnetic hyperthermia application. First, the influence of experimental conditions such as co-precipitant, bath temperature, and pH on the morphology and magnetic properties of SPIONs was investigated. Then, the superparamagnetic particles were coated with the hydroxyapatite layer for further loading of anticancer drugs, determining the optimal thickness of the HAp shell. The composite was fabricated by the wet chemical process and was characterized by optimizing the experimental conditions of the wiring synthesis to obtain the superparamagnetic spherical material with a high HAp loading as a platform for drug uptake. SEM and TEM studies confirmed the round shape of the magnetic core up to 15 nm in size with a well-defined HAp shell. After checking the material’s superparamagnetic properties, the temperature dependence on time and alternating magnetic field strength was tested and optimized in hyperthermia experiments. Full article
(This article belongs to the Special Issue Applications of Magnetic Materials in Medicine: Knowledge and Perspectives)
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