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9.6
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Journals
Marine Drugs
Special Issues
Application of Marine Nature Products to Reduce Oxidative Stress
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Application of Marine Nature Products to Reduce Oxidative Stress

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Pharmacology".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 205

Special Issue Editor

Prof. Dr. Chieh-Hsi Wu

E-Mail Website
Guest Editor
School of Pharmacy, Taipei Medical University, Taipei 110, Taiwan
Interests: restenosis; gene therapy; cancer research
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oxidative stress has been known as one of the major causes of many devastating diseases, including cancer, heart attack, liver cirrhosis, Alzheimer's disease, and Parkinson's disease. Many marine natural products have been extensively studied for their antioxidative properties as potential pharmaceutical remedies. Compared to land natural products, marine products may have distinct profiles, including different compositions and biological natures. Given your strong dedication and extensive research experience with marine natural products, we would greatly appreciate your contribution to this Special Issue on “Application of Marine Nature Products to Reduce Oxidative Stress”. I truly believe that your involvement in this Special Issue will have a tremendous impact on marine natural product research.

Prof. Dr. Chieh-Hsi Wu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • free radicals
  • inflammation
  • marine products
  • microbiota
  • system biology
  • signal transduction

Published Papers (1 paper)

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Research

15 pages, 2231 KiB  
Article
C-Phycoerythrin Prevents Chronic Kidney Disease-Induced Systemic Arterial Hypertension, Avoiding Oxidative Stress and Vascular Dysfunction in Remanent Functional Kidney
by Oscar Iván Florencio-Santiago, Vanesa Blas-Valdivia, José Iván Serrano-Contreras, Placido Rojas-Franco, Gerardo Norberto Escalona-Cardoso, Norma Paniagua-Castro, Margarita Franco-Colin and Edgar Cano-Europa
Mar. Drugs 2024, 22(8), 337; https://doi.org/10.3390/md22080337 - 25 Jul 2024
Abstract
Chronic kidney disease (CKD) is a burden in low- and middle-income countries, and a late diagnosis with systemic arterial hypertension (SAH) is the major complication of CKD. C-phycoerythrin (CPE) is a bioactive compound derived from Phormidium persicinum that presents anti-inflammatory and antioxidant effects [...] Read more.
Chronic kidney disease (CKD) is a burden in low- and middle-income countries, and a late diagnosis with systemic arterial hypertension (SAH) is the major complication of CKD. C-phycoerythrin (CPE) is a bioactive compound derived from Phormidium persicinum that presents anti-inflammatory and antioxidant effects in vitro and nephroprotective effects in vivo. In the current study, we determine the antihypertensive effect of CPE in a 5/6 nephrectomy-induced CKD model using twenty normotensives male Wistar rats, grouped into four groups (n = 5): sham; sham + CPE; 5/6 nephrectomy (NFx); and NFx + CPE. Treatment started a week post-surgery and continued for five weeks, with weekly hemodynamic evaluations. Following treatment, renal function, oxidative stress, and the expression of vascular dysfunction markers were assessed. The renal function analysis revealed CKD hyperfiltration, and the hemodynamic evaluation showed that SAH developed at the third week. AT1R upregulation and AT2R downregulation together with Mas1/p-Akt/p-eNOS axis were also observed. CPE treatment mitigated renal damage, preserved renal function, and prevented SAH with the modulation of the vasodilative AT1R, AT2R, and Mas1/pAKT/peNOS axis. This result reveals that CPE prevented CKD progression to SAH by avoiding oxidative stress and vascular dysfunction in the kidneys. Full article
(This article belongs to the Special Issue Application of Marine Nature Products to Reduce Oxidative Stress)
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