Marine Natural Products in Anti-obesity and Metabolic Syndrome

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine-Derived Ingredients for Drugs, Cosmeceuticals and Nutraceuticals".

Deadline for manuscript submissions: closed (31 October 2024) | Viewed by 2975

Special Issue Editor

College of Life Sciences, Qingdao University, Qingdao, China
Interests: nutrition; functional foods; lipids; peptides; metabolic syndrome

Special Issue Information

Dear Colleagues,

Metabolic syndrome (MS) is a collection of multiple risk factors for type 2 diabetes mellitus and cardiovascular disease, including obesity, insulin resistance, hyperglycemia, dyslipidemia, hypertension and hyperuricemia. It is not a disease but a common complex entity that represents a worldwide epidemic and major public health concern, affecting approximately 30% of adults globally. Currently, the accurate pathogenesis of MS is still unclear, with central obesity and insulin resistance playing critical roles in initiating and perpetuating its pathologic features. To date, lifestyle interventions are still the main therapeutic strategies for the treatment of MS. Nowadays, increasing evidence suggests that marine natural products have effective ameliorative effects on MS-related metabolic abnormalities, explain their emergence as a potential preventive strategy for the syndrome. For this Special Issue, we invite original research papers and reviews on the current knowledge of the protective effects of marine natural products on metabolic syndrome and related metabolic abnormalities.

Dr. Xiang Gao
Guest Editor

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Keywords

  • marine natural products
  • metabolic syndrome
  • anti-obesity
  • cardiovascular disease
  • diabetes mellitus
  • dyslipidemia
  • hypertension

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Published Papers (2 papers)

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Research

15 pages, 1932 KiB  
Article
Elements in Serum, Muscle, Liver, and Kidney of Rabbits Fed Macroalgae-Supplemented Diets
by Sabela Al-Soufi, Marta Miranda, Javier García, Antonio Muíños, Eugenio Cegarra, Nuria Nicodemus, Carlos Herrero-Latorre and Marta López-Alonso
Mar. Drugs 2024, 22(6), 263; https://doi.org/10.3390/md22060263 - 7 Jun 2024
Viewed by 1053
Abstract
The addition of marine macroalgae to animal feed has garnered interest due to the demonstrated benefits of gut health in many livestock species. Most macroalgae have a higher mineral content than terrestrial vegetables, making them an attractive, sustainable source of minerals. However, some [...] Read more.
The addition of marine macroalgae to animal feed has garnered interest due to the demonstrated benefits of gut health in many livestock species. Most macroalgae have a higher mineral content than terrestrial vegetables, making them an attractive, sustainable source of minerals. However, some macroalgae contain elevated concentrations of iodine and arsenic, which may be transferred to the meat of livestock fed with macroalgae. This study evaluated the mineral profile of rabbit serum, muscle, liver, and kidney of rabbits fed diets supplemented with different marine macroalgae, with the goal of improving post-weaning gut health and reducing reliance on antibiotics. We found increased deposition of iodine in muscle, liver, and kidney due to macroalgae supplementation, which is particularly promising for regions with low iodine endemicity. Higher, though relatively low arsenic concentrations, compared to those in other animal meats and food sources, were also detected in the muscle, liver, and kidney of macroalgae-fed rabbits. The absence of apparent interactions with other micronutrients, particularly selenium, suggests that the inclusion of macroalgae in rabbit diets will not affect the overall mineral content. Enhanced bioavailability of elements such as phosphorus and iron may provide additional benefits, potentially reducing the need for mineral supplementation. Full article
(This article belongs to the Special Issue Marine Natural Products in Anti-obesity and Metabolic Syndrome)
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14 pages, 2861 KiB  
Article
Pinctada martensii Hydrolysate Modulates the Brain Neuropeptidome and Proteome in Diabetic (db/db) Mice via the Gut–Brain Axis
by Jiayun Li, Yijun Lv, Yuanqing Wei, Xinzhi Wang, Shenghan Yan, Binyuan Zhao, Jipeng Sun, Rui Liu and Yueyang Lai
Mar. Drugs 2024, 22(6), 249; https://doi.org/10.3390/md22060249 - 28 May 2024
Viewed by 1354
Abstract
Pinctada martensii hydrolysate (PMH) has been proved to have the effect of ameliorating disorders of glucose and lipid metabolism in db/db mice, but the mechanism of its hyperglycemia effect is still unclear. Bacterial communities in fecal samples from a normal control group, a [...] Read more.
Pinctada martensii hydrolysate (PMH) has been proved to have the effect of ameliorating disorders of glucose and lipid metabolism in db/db mice, but the mechanism of its hyperglycemia effect is still unclear. Bacterial communities in fecal samples from a normal control group, a diabetic control group, and a PMH-treated diabetes mellitus type 2 (T2DM) group were analyzed by 16S gene sequencing. Nano LC-MS/MS was used to analyze mice neuropeptides and proteomes. The 16S rDNA sequencing results showed that PMH modulated the structure and composition of the gut microbiota and improved the structure and composition of Firmicutes and Bacteroidetes at the phylum level and Desulfovibrionaceae and Erysipelatoclostridiaceae at the family level. Furthermore, the expressions of functional proteins of the central nervous system, immune response-related protein, and proteins related to fatty acid oxidation in the brain disrupted by an abnormal diet were recovered by PMH. PMH regulates the brain neuropeptidome and proteome and further regulates blood glucose in diabetic mice through the gut–brain axis. PMH may be used as a prebiotic agent to attenuate T2DM, and target-specific microbial species may have unique therapeutic promise for metabolic diseases. Full article
(This article belongs to the Special Issue Marine Natural Products in Anti-obesity and Metabolic Syndrome)
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