Terpenes and Polyketides of Marine Origins

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 1516

Special Issue Editor


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Guest Editor
School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning, China
Interests: bioactive natural products; marine microorganism; terpenes

Special Issue Information

Dear Colleagues,

The marine environment harbors millions of macro- and micro-organisms, which produce a plethora of novel secondary metabolites. To date, more than 20,000 new compounds have been isolated from marine organisms in various countries around the world, many of which are currently the subject of pharmaceutical evaluation and preclinical research.

Terpenes and polyketides are the two most common natural organic compounds found in the ocean, and are mainly derived from seaweed, sponges, soft corals, mollusks, and micro-organisms. Most of these marine terpenes and polyketides are bioactive substances with interesting structures and unique physiological functions.

This Special Issue will focus on terpenes and polyketides of marine origin, including, but not limited to, the isolation–structure elucidation of new substances, the evaluation of their bioactivities, the clarification of their mechanism of action, as well as their biosynthesis and chemical synthesis.

Dr. Fandong Kong
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • terpenes
  • polyketides
  • marine natural products
  • new substances
  • bioactivities
  • mechanism of action

Published Papers (1 paper)

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Research

11 pages, 3210 KiB  
Article
Anti-Inflammatory and Proangiogenic Metabolites from the Hadal Trench-Derived Fungus Acremonium dichromosporum YP-213
by Yan Zhang, Jia-Bao Zhou, Shu-Ting Yang, Xin Liu, Wei Cao, Pei-Hai Li, Hao Chen and Ya-Qin Fan
Mar. Drugs 2024, 22(1), 25; https://doi.org/10.3390/md22010025 - 29 Dec 2023
Viewed by 1370
Abstract
Four new compounds, including two ascochlorin-type meroterpenoids acremocholrins A (1) and B (2), one pyridone alkaloid acremopyridone A (7), and one cyclopentenone derivative acremoketene A (12), together with eight known compounds (36 [...] Read more.
Four new compounds, including two ascochlorin-type meroterpenoids acremocholrins A (1) and B (2), one pyridone alkaloid acremopyridone A (7), and one cyclopentenone derivative acremoketene A (12), together with eight known compounds (36 and 811), were isolated and identified from the hadal trench-derived fungus Acremonium dichromosporum YP-213. Their structures were determined with a detailed spectroscopic analysis of NMR and MS data, NOE analysis, octant rule and quantum chemical calculations of ECD, and NMR (with DP4+ probability analysis). Among the compounds, 7 represent a novel scaffold derived from a pyridone alkaloid by cleavage of the C-16-C-17 bond following oxidation to give a ketone. Compounds 9, 11, and 12 showed potent in vivo anti-inflammatory activity in transgenic zebrafish, while compound 8 exhibited significant proangiogenic activity in transgenic zebrafish. Full article
(This article belongs to the Special Issue Terpenes and Polyketides of Marine Origins)
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