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Marine Drugs
Special Issues
Bioactive Compounds from Marine Bivalves and Associated Micro-Organisms
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Bioactive Compounds from Marine Bivalves and Associated Micro-Organisms

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (15 November 2020) | Viewed by 5980

Special Issue Editor

Dr. Réjean Tremblay

E-Mail Website
Guest Editor
Institut des Sciences de la mer de Rimouski (ISMER), Université du Québec à Rimouski, 310, allée des Ursulines, Rimouski, QC G5L 3A1, Canada
Interests: aquaculture; ecophysiology; recruitment

Special Issue Information

Dear Colleagues,

This Special Issue of Marine Drugs is dedicated to innovative and original research on bioactive compounds originating from marine bivalves and associated micro-organisms. We consider bioactive compounds as a general term for a class of substances capable of modulating metabolic processes and resulting in the promotion of better health. They exhibit beneficial effects or therapeutic potential, such as reducing pro-inflammatory state, promoting antioxidant activity, influencing energy intake, inhibiting receptor activities, and inhibiting or inducting gene expression and enzymes. This issue will be the first Special Issue to complement the existing literature in marine bivalves, which have been recognized to produce a variety of bioactive compounds and which represent a seafood whose popularity has increased steadily over the past few decades. The global marine bivalve production for human consumption represents near 15% of the total marine production in the world for more than 15 million tonnes per year. All sources and species will be included, i.e., traditionally farmed, fished, and the non-exploited ones representing more than 9000 species. Furthermore, the bioactive compounds (peptides, lipids, pigments and others) by the micro-organisms ingested as a food source (planktonic species) and their microbionts will be included in this Special Issue.


Dr. Réjean Tremblay
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Bioactivity
  • Natural compounds
  • Marine bivalves
  • Microbionts
  • Phytoplankton
  • Aquaculture
  • Fisheries
  • Natural stocks

Published Papers (2 papers)

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Research

23 pages, 752 KiB  
Article
Extraction Improvement of the Bioactive Blue-Green Pigment “Marennine” from Diatom Haslea ostrearia’s Blue Water: A Solid-Phase Method Based on Graphitic Matrices
by William Bélanger, Alexandre A. Arnold, François Turcotte, Richard Saint-Louis, Jean-Sébastien Deschênes, Bertrand Genard, Isabelle Marcotte and Réjean Tremblay
Mar. Drugs 2020, 18(12), 653; https://doi.org/10.3390/md18120653 - 18 Dec 2020
Cited by 5 | Viewed by 2673
Abstract
The compound “marennine” is a blue–green pigment produced by the benthic microalgae Haslea ostrearia, with pathogenicity reduction activities against some bacteria and promising potential as a natural pigment in seafood industries. After decades of research, the chemical family of this compound still [...] Read more.
The compound “marennine” is a blue–green pigment produced by the benthic microalgae Haslea ostrearia, with pathogenicity reduction activities against some bacteria and promising potential as a natural pigment in seafood industries. After decades of research, the chemical family of this compound still remains unclear, mainly because structural studies were impaired by the presence of co-extracted compounds in marennine isolates. To improve the purity of marennine extract, we developed a novel extraction method using a graphitic stationary phase, which provides various advantages over the previous procedure using tandem ultrafiltration. Our method is faster, more versatile, provides a better crude yield (66%, compared to 57% for ultrafiltration) and is amenable to upscaling with continuous photobioreactor cultivation. Our goal was to take advantage of the modulable surface properties of the graphitic matrix by optimizing its interactions with marennine. As such, the effects of organic modifiers, pH and reducing agents were studied. With this improvement on marennine purification, we achieved altogether the isolation of a fucoidan-related, sulfated polysaccharide from blue water. Characterization of the polysaccharides fraction suggests that roughly half of UV-absorbing compounds could be isolated from the marennine crude extracts. The identification of sulfated polysaccharides could be a major breakthrough for marennine purification, providing targeted isolation techniques. Likewise, the added value of Haslea ostrearia and the role of polysaccharides in previous marennine chemical characterization and bioactivity studies remain to be determined. Full article
(This article belongs to the Special Issue Bioactive Compounds from Marine Bivalves and Associated Micro-Organisms)
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19 pages, 2115 KiB  
Article
Bioavailability of Orally Administered Active Lipid Compounds from four Different Greenshell™ Mussel Formats
by Matthew R. Miller, Marlena C. Kruger, Chris Wynne, Devonie Waaka, Weili Li, Chris Frampton, Fran M. Wolber and Charles Eason
Mar. Drugs 2020, 18(11), 524; https://doi.org/10.3390/md18110524 - 23 Oct 2020
Cited by 6 | Viewed by 2774
Abstract
Greenshell™ mussel (GSM, Perna canaliculus) is New Zealand’s most important aquaculture species. They are a good source of long chain-polyunsaturated fatty acids (n-3 LC PUFA). Beyond a traditional food product, GSMs are also sold as mussel powders and oil extract [...] Read more.
Greenshell™ mussel (GSM, Perna canaliculus) is New Zealand’s most important aquaculture species. They are a good source of long chain-polyunsaturated fatty acids (n-3 LC PUFA). Beyond a traditional food product, GSMs are also sold as mussel powders and oil extract formats in the nutraceutical markets. In this study, a four-sequence, single dose, randomized crossover human trial with eight evaluable healthy male participants was undertaken to determine the bioavailability of the n-3 LC PUFA in four different GSM formats (oil, powder, food ingredient and half-shell unprocessed whole mussel) by measuring area under the curve (AUC) and maximal concentration (CMax). Blood samples were collected at baseline and up to 48 h after initiation of product consumption in each administration period. There were minor differences between the bioavailability of FA (fatty acid) between the different GSM formats. Eicosapentaenoic acid (EPA) peak concentrations and plasma exposures were significantly lower with GSM oil compared to GSM half-shell and GSM powder formats, which resulted in AUC0–48 for the intake of GSM half-shell mussel and GSM powder being significantly higher than that for GSM oil (p = 0.013, f= 4.84). This equated to a 20.6% and 24.3% increase in the amount of EPA present in the plasma after consumption of half-shell mussels and mussel powder respectively compared to GSM oil. GSM oil produced the shortest median time to maximal plasma n-3 LC PUFA concentration of all evaluated products demonstrated by a shorter maximum measured plasma concentration (TMax = 5 h). Docosahexaenoic acid (DHA) and n-3 LC PUFA plasma exposure parameters were statistically comparable across the four GSM products evaluated. Full article
(This article belongs to the Special Issue Bioactive Compounds from Marine Bivalves and Associated Micro-Organisms)
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