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Marine Drugs
Special Issues
MS- or NMR-Guided Discovery of Marine Specialized Metabolites
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MS- or NMR-Guided Discovery of Marine Specialized Metabolites

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Structural Studies on Marine Natural Products".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 1065

Special Issue Editors

Prof. Dr. Raphael Reher

E-Mail Website
Guest Editor
Institute of Pharmaceutical Biology and Biotechnology, University of Marburg, Marburg, Germany
Interests: specialized metabolites; structure elucidation; drug discovery; chemical ecology; (native) metabolomics; NMR spectroscopy; G protein modulators
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Till F. Schäberle

E-Mail Website
Guest Editor
Institute for Insect Biotechnology, Justus-Liebig-University Giessen, Giessen, 35392, Germany
Interests: specialized metabolites; biosynthesis; drug discovery; anti-infectives Interests: antibiotics; heterologous expression; metabolomics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Once overlooked, marine organisms have emerged as a rich reservoir of marine specialized metabolites, showcasing distinctive structures and bioactivities.

Open-access FAIR-compliant metabolomics databases like MASSIVE (for MS) and NP-MRD (for NMR) provide extensive and highly complementary datasets. Furthermore, downstream computational methods for NMR and MS analysis have greatly expedited the dereplication and prioritization of specialized metabolites, facilitating their structural elucidation.

This Special Issue invites articles from both MS- and/or NMR-driven studies on marine organisms with a focus on marine specialized metabolite discovery and metabolome classification. Articles describing new methods for specialized metabolite discovery are also welcome.

Prof. Dr. Raphael Reher
Prof. Dr. Till F. Schäberle
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine specialized metabolites
  • metabolomics
  • mass spectrometry
  • molecular networking
  • NMR spectroscopy
  • structure elucidation
  • machine learning

Published Papers (1 paper)

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Research

14 pages, 1733 KiB  
Article
Miniaturized Cultivation Profiling (MATRIX)-Facilitated Discovery of Noonazines A–C and Noonaphilone A from an Australian Marine-Derived Fungus, Aspergillus noonimiae CMB-M0339
by Sarani Kankanamge, Paul V. Bernhardt, Zeinab G. Khalil and Robert J. Capon
Mar. Drugs 2024, 22(6), 243; https://doi.org/10.3390/md22060243 - 27 May 2024
Viewed by 872
Abstract
Subjecting the Australian marine-derived fungus Aspergillus noonimiae CMB-M0339 to cultivation profiling using an innovative miniaturized 24-well plate format (MATRIX) enabled access to new examples of the rare class of 2,6-diketopiperazines, noonazines A–C (1–3), along with the known analogue coelomycin [...] Read more.
Subjecting the Australian marine-derived fungus Aspergillus noonimiae CMB-M0339 to cultivation profiling using an innovative miniaturized 24-well plate format (MATRIX) enabled access to new examples of the rare class of 2,6-diketopiperazines, noonazines A–C (1–3), along with the known analogue coelomycin (4), as well as a new azaphilone, noonaphilone A (5). Structures were assigned to 1–5 on the basis of a detailed spectroscopic analysis, and in the case of 1–2, an X-ray crystallographic analysis. Plausible biosynthetic pathways are proposed for 1–4, involving oxidative Schiff base coupling/dimerization of a putative Phe precursor. Of note, 2 incorporates a rare meta-Tyr motif, typically only reported in a limited array of Streptomyces metabolites. Similarly, a plausible biosynthetic pathway is proposed for 5, highlighting a single point for stereo-divergence that allows for the biosynthesis of alternate antipodes, for example, the 7R noonaphilone A (5) versus the 7S deflectin 1a (6). Full article
(This article belongs to the Special Issue MS- or NMR-Guided Discovery of Marine Specialized Metabolites)
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