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Marine Drugs
Special Issues
Vascular Bioactivities of Marine Natural Products
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Vascular Bioactivities of Marine Natural Products

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (20 December 2019) | Viewed by 8627

Special Issue Editor

Prof. Dr. Assunta Pandolfi

E-Mail Website
Guest Editor
Department of Medical, Oral and Biotechnological Sciences, University G. d’Annunzio Chieti-Pescara, Center for Advanced Studies and Technology (CAST), 66100 Chieti, Italy
Interests: inflammation; endothelial cells; tissue regeneration; stem cells; cell differentiation; bioactive compounds; innovative cell cultures
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The constant increase in human life expectancy has significantly accounted for the increase of the risk of cardiovascular diseases among other disorders such as type II diabetes, obesity, neurodegenerative  and oncological diseases. These age-related disorders may be considered one of the most demanding worldwide health problems.

Numerous approaches have been described to delay and possibly treat cardiovascular disease and other age-related disorders; of these, some take account of the use of natural molecules and nutritional supplements.

Notably, the marine ecosystem presents an interesting source of new isolable bioactive compounds with diversified chemical structures, which are also believed to be an effective source of drug discovery.

In the last two decades, in fact, a large screening of marine compounds has been conducted and a wide range of activities, such as anti-inflammatory and/or anti-oxidant activities, have been reported. This supported the development of a recent discipline named marine pharmacology, which investigates the sea milieu looking for potential new pharmaceuticals.

These recent findings have established that such marine natural compounds have potential promising and significant vascular bioactivities, which may trigger the discovery of new drugs for the management of cardiovascular diseases, generally found in elderly people. 

In this Special Issue we invite researchers to contribute original research articles and review articles that address primary and secondary metabolites of marine origin with vascular biological properties, which can be used either as supplements or marine natural products, but also as potential drugs that can delay the morbidity and mortality of related cardiovascular disorders.

As Guest Editor, I invite you to contribute to the Special Issue on the “Vascular Bioactivities of Marine Natural Products”. Original research reports and reviews will be published online in Marine Drugs.

Prof. Assunta Pandolfi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine metabolites
  • antioxidant activity
  • anti-inflammatory activity
  • vascular cells
  • endothelial dysfunction
  • nitric oxide bioavailability
  • cardiovascular disease

Published Papers (2 papers)

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Research

17 pages, 2582 KiB  
Article
Pharmaceutical Development and Safety Evaluation of a GMP-Grade Fucoidan for Molecular Diagnosis of Cardiovascular Diseases
by Cédric Chauvierre, Rachida Aid-Launais, Joël Aerts, Frédéric Chaubet, Murielle Maire, Lucas Chollet, Lydia Rolland, Roberta Bonafé, Silvia Rossi, Simona Bussi, Claudia Cabella, Laszlo Dézsi, Tamas Fülöp, Janos Szebeni, Youssef Chahid, Kang H. Zheng, Erik S. G. Stroes, Dominique Le Guludec, François Rouzet and Didier Letourneur
Mar. Drugs 2019, 17(12), 699; https://doi.org/10.3390/md17120699 - 12 Dec 2019
Cited by 26 | Viewed by 3651
Abstract
The adhesion molecule P-selectin is present on the cell surface of both activated endothelium and activated platelets. The present study describes the pharmaceutical development, safety evaluation, and preclinical efficacy of a micro-dosed radiotracer. The macromolecular nanoscale assembly consisted of a natural compound made [...] Read more.
The adhesion molecule P-selectin is present on the cell surface of both activated endothelium and activated platelets. The present study describes the pharmaceutical development, safety evaluation, and preclinical efficacy of a micro-dosed radiotracer. The macromolecular nanoscale assembly consisted of a natural compound made of a sulfated fucose-rich polysaccharides (fucoidan) and a radionuclide (technetium-99m) for the detection of P-selectin expression in cardiovascular diseases. After extraction and fractionation from brown seaweeds, the good manufacturing practice (GMP) production of a low molecular weight (LMW) fucoidan of 7 kDa was achieved and full physicochemical characterization was performed. The regulatory toxicology study in rats of the GMP batch of LMW fucoidan revealed no adverse effects up to 400 μg/kg (×500 higher than the expected human dose) and pseudoallergy was not seen as well. In a myocardial ischemia-reperfusion model in rats, the GMP-grade LMW fucoidan labeled with technetium-99m detected P-selectin upregulation in vivo. The present study supports the potential of using 99mTc-fucoidan as an imaging agent to detect activated endothelium in humans. Full article
(This article belongs to the Special Issue Vascular Bioactivities of Marine Natural Products)
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14 pages, 1393 KiB  
Article
High-Performance Thin-Layer Chromatography Hyphenated with Microchemical and Biochemical Derivatizations in Bioactivity Profiling of Marine Species
by Snezana Agatonovic-Kustrin, Ella Kustrin, Vladimir Gegechkori and David W. Morton
Mar. Drugs 2019, 17(3), 148; https://doi.org/10.3390/md17030148 - 3 Mar 2019
Cited by 33 | Viewed by 4602
Abstract
Marine organisms produce an array of biologically active natural products, many of which have unique structures that have not been found in terrestrial organisms. Hence, marine algae provide a unique source of bioactive compounds. The present study investigated 19 marine algae and one [...] Read more.
Marine organisms produce an array of biologically active natural products, many of which have unique structures that have not been found in terrestrial organisms. Hence, marine algae provide a unique source of bioactive compounds. The present study investigated 19 marine algae and one seagrass collected from Torquay beach, Victoria, Australia. High-performance thin-layer chromatography (HPTLC) hyphenated with microchemical (DPPH•, p-anisaldehyde, and Fast Blue B) and biochemical (α-amylase and acetylcholine esterase (AChE) enzymatic) derivatizations was used to evaluate antioxidant activity, presence of phytosterols and phenolic lipids, α-amylase and AChE inhibitory activities of extract components. Significant α-amylase and AChE inhibitory activities were observed in samples 2, 6, 8 and 10. Antioxidant activities in the samples were found to be correlated to phytosterol content (R2 = 0.78), but was not found to be related to either α-amylase or AChE inhibitory activities. α-Amylase inhibitory activities were correlated to AChE inhibition (R2 = 0.77) and attributed to the phytosterol content, based on the similar peak position in the chromatograms with the β-sitosterol chromatogram. Samples 1, 8, and especially sample 20, were found to contain phenolic lipids (alkyl resorcinol derivatives) with significant antioxidant activities. The results suggest that these marine species have a significant number of bioactive compounds that warrant further investigation. Full article
(This article belongs to the Special Issue Vascular Bioactivities of Marine Natural Products)
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