Collagen and Chitin from Marine Resources and Their Interdisciplinary Applications—2nd Edition

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Biomaterials of Marine Origin".

Deadline for manuscript submissions: closed (30 September 2025) | Viewed by 6547

Special Issue Editor

Special Issue Information

Dear Colleagues,

Following the success of the first edition this Special Issue, “Collagen and Chitin from Marine Resources and Their Interdisciplinary Applications”, we are delighted to announce its second edition.

Marine collagen and chitin have great potential applications in drug discovery, drug delivery, wound healing, tissue engineering, antiaging, agriculture, and environmental fields. These two biopolymers also exhibit similar hierarchical structural organizations. After cellulose, chitin is the world's second-most important natural polymer and has been identified in bacteria, fungi, plants, and marine invertebrates. Chitin can also be enzymatically deacetylated to chitosan, a more flexible and soluble biopolymer. As mentioned above, it has many applications, including in the biomedical, environmental, and agricultural sectors. Similarly, nature is a source of massive quantities of collagen, especially in marine organisms. Collagen is the main fibrous structural protein in animals' extracellular matrix and connective tissue. It contributes greatly to biotechnology products and medical applications.

As the Guest Editor of this Special Issue, I would like to invite you to submit recent innovations for these two biopolymers, including original studies, reviews, short communications, and innovations in biological sources and their promising applications.

Dr. Azizur Rahman
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine collagen
  • marine chitin
  • chitosan
  • marine proteins and peptides
  • biopolymers
  • corals
  • sponges
  • sea urchins
  • marine fish
  • mollusks/bivalves
  • marine algae
  • marine polysaccharides
  • marine bioactive compounds
  • marine biotechnology
  • marine biomaterials
  • proteomics

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Published Papers (3 papers)

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Research

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24 pages, 2295 KB  
Article
Sea Cucumber (Isostichopus badionotus): Bioactivity and Wound Healing Capacity In Vitro of Small Peptide Isolates from Digests of Whole-Body Wall or Purified Collagen
by Leticia Olivera-Castillo, George Grant, Oscar Medina-Contreras, Honorio Cruz-López, Leydi Carrillo-Cocom, Ariadnna Cruz-Córdova, Frank Segura-Cadiz, Daniel Alejandro Fernández-Velasco, Sergio Rodríguez-Morales, Juan Valerio Cauich-Rodríguez, Rosa Esther Moo-Puc, César Puerto-Castillo, Gabriela de Jesus Moo-Pech, Jonatan Jafet Uuh-Narvaez, Miguel Angel Olvera-Novoa and Rossanna Rodriguez-Canul
Mar. Drugs 2025, 23(11), 411; https://doi.org/10.3390/md23110411 - 22 Oct 2025
Viewed by 674
Abstract
Low-molecular-weight peptides derived from the digestion of body wall proteins in some sea cucumber species have wound-healing and health-promoting properties, but their potency varies widely by species, growth environment, age, and season. For the first time, small peptide (1–3 kDa) fractions have been [...] Read more.
Low-molecular-weight peptides derived from the digestion of body wall proteins in some sea cucumber species have wound-healing and health-promoting properties, but their potency varies widely by species, growth environment, age, and season. For the first time, small peptide (1–3 kDa) fractions have been isolated from the whole-body wall of the sea cucumber Isostichopus badionotus and its constituent collagen and tested for wound healing capacity in vitro. Ultrafiltered digests (1–3 kDa) of the pure collagen, as well as 1–3 kDa digests of the whole-body wall, had potent antioxidant activities and promoted rapid wound healing in a keratinocyte scratch wound assay. Gene expression studies suggested that the wound-healing actions of the individual collagen and body wall 1–3 kDa fractions differed significantly. Low-molecular-weight peptides derived from I. badionotus collagen did promote wound healing in vitro; however, their efficacy may have been modulated by additional factors produced during body wall or collagen digestion. These findings need to be confirmed in vivo. Full article
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16 pages, 3734 KB  
Article
Preparation and Properties of Crosslinked Quaternized Chitosan-Based Hydrogel Films Ionically Bonded with Acetylsalicylic Acid for Biomedical Materials
by Jingjing Zhang, Linqing Wang, Yingqi Mi, Fang Dong and Zhanyong Guo
Mar. Drugs 2024, 22(10), 450; https://doi.org/10.3390/md22100450 - 30 Sep 2024
Cited by 5 | Viewed by 2144
Abstract
The aim of the current study is to develop chitosan-based biomaterials which can sustainably release acetylsalicylic acid while presenting significant biological activity. Herein, an innovative ionic bonding strategy between hydroxypropyl trimethyl ammonium chloride chitosan (HACC) and acetylsalicylic acid (AA) was proposed, skillfully utilizing [...] Read more.
The aim of the current study is to develop chitosan-based biomaterials which can sustainably release acetylsalicylic acid while presenting significant biological activity. Herein, an innovative ionic bonding strategy between hydroxypropyl trimethyl ammonium chloride chitosan (HACC) and acetylsalicylic acid (AA) was proposed, skillfully utilizing the electrostatic attraction of the ionic bond to achieve the controlled release of drugs. Based on this point, six crosslinked N-[(2-hydroxy-3-trimethylammonium)propyl]chitosan acetylsalicylic acid salt (CHACAA) hydrogel films with varying acetylsalicylic acid contents were prepared by a crosslinking reaction. The results of 1H nuclear magnetic resonance spectroscopy (1H NMR) and scanning electron morphology (SEM) confirmed the crosslinked structure, while the obtained hydrogel films possessed favorable thermal stability, mechanical properties, and swelling ability. In addition, the drug release behavior of the hydrogel films was also investigated. As expected, the prepared hydrogel films demonstrated the capability for the sustainable release of acetylsalicylic acid due to ion pair attraction dynamics. Furthermore, the bioactivities of CHACAA-3 and CHACAA-4 hydrogel films with acetylsalicylic acid molar equivalents of 1.25 and 1.5 times those of HACC were particularly pronounced, which not only exhibited an excellent drug sustained-release ability and antibacterial effect, but also had a higher potential for binding and scavenging inflammatory factors, including NO and TNF-α. These findings suggest that CHACAA-3 and CHACAA-4 hydrogel films hold great potential for applications in wound dressing, tissue engineering scaffolds, and drug carriers. Full article
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Review

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25 pages, 2493 KB  
Review
Comprehensive Review on Application Progress of Marine Collagen Cross-Linking Modification in Bone Repairs
by Xiaofei Zhai, Xinrong Geng, Wenjun Li, Hongli Cui, Yunqing Wang and Song Qin
Mar. Drugs 2025, 23(4), 151; https://doi.org/10.3390/md23040151 - 30 Mar 2025
Cited by 7 | Viewed by 2796
Abstract
Bone tissue injuries are a significant health risk, and their repair is challenging. While various materials have potential for bone repair, issues like sourcing and immune rejection limit their use. Marine-derived collagen, abundant and free from religious and disease transmission concerns, is a [...] Read more.
Bone tissue injuries are a significant health risk, and their repair is challenging. While various materials have potential for bone repair, issues like sourcing and immune rejection limit their use. Marine-derived collagen, abundant and free from religious and disease transmission concerns, is a promising biomaterial in bone tissue engineering. Cross-linking modification can enhance its mechanical properties and degradation rate, making it more suitable for bone repair. However, detailed analysis of cross-linking methods, property changes post-cross-linking, and their impact on bone repair is needed. This review examines marine collagen’s modification methods, improved characteristics, and potential in bone tissue repair, providing a foundation for its effective use in bone tissue engineering. Full article
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