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Marine Drugs
Special Issues
Marine Cyclic Peptides: Isolation, Synthesis and Biological Activities
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Marine Cyclic Peptides: Isolation, Synthesis and Biological Activities

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (22 December 2021) | Viewed by 9080

Special Issue Editor

Prof. Dr. Nicolas Inguimbert

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Guest Editor
Laboratoire d'Excellence Corail, Université de Perpignan Via Domitia, 58 Avenue Paul Alduy, 66860 Perpignan, France
Interests: Peptide synthesis; Organic Chemistry; Marine Peptides; SAR studies

Special Issue Information

Dear Colleagues,

Marine Cyclic Peptides are complex compounds exhibiting a wide array of biological activities thanks to their structures containing non-natural amino acids that have no equivalent at the terrestrial level. They are isolated from various marine species which use them as defense tools but they constitute also new chemical scaffolds and pharmaceutically potent molecules from which some are clinically used or in preclinical assays. Further study of these compounds are often impaired by their isolation in minute quantities, thus prompting chemist to engage in their synthesis, which allows in turn structure confirmation.

This special issue is intended to publish research highlighting isolation by biological activities guided protocols. Articles dealing with their synthesis for structure confirmation or the establishment of structure/activity relationships along with their biological activities are welcome. Review articles relating to a particular class of cyclic marine peptides will also be considered.

Prof. Dr. Nicolas Inguimbert
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

 

  • Marine natural compounds
  • Cyclic peptides
  • Lipopeptides
  • bioactive compounds
  • structure activity relationship

 

Published Papers (2 papers)

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Review

45 pages, 13976 KiB  
Review
Thirtieth Anniversary of the Discovery of Laxaphycins. Intriguing Peptides Keeping a Part of Their Mystery
by Laurine Darcel, Sanjit Das, Isabelle Bonnard, Bernard Banaigs and Nicolas Inguimbert
Mar. Drugs 2021, 19(9), 473; https://doi.org/10.3390/md19090473 - 24 Aug 2021
Cited by 5 | Viewed by 2998
Abstract
Lipopeptides are a class of compounds generally produced by microorganisms through hybrid biosynthetic pathways involving non-ribosomal peptide synthase and a polyketyl synthase. Cyanobacterial-produced laxaphycins are examples of this family of compounds that have expanded over the past three decades. These compounds benefit from [...] Read more.
Lipopeptides are a class of compounds generally produced by microorganisms through hybrid biosynthetic pathways involving non-ribosomal peptide synthase and a polyketyl synthase. Cyanobacterial-produced laxaphycins are examples of this family of compounds that have expanded over the past three decades. These compounds benefit from technological advances helping in their synthesis and characterization, as well as in deciphering their biosynthesis. The present article attempts to summarize most of the articles that have been published on laxaphycins. The current knowledge on the ecological role of these complex sets of compounds will also be examined. Full article
(This article belongs to the Special Issue Marine Cyclic Peptides: Isolation, Synthesis and Biological Activities)
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Graphical abstract

17 pages, 6469 KiB  
Review
Improvement on Permeability of Cyclic Peptide/Peptidomimetic: Backbone N-Methylation as A Useful Tool
by Yang Li, Wang Li and Zhengshuang Xu
Mar. Drugs 2021, 19(6), 311; https://doi.org/10.3390/md19060311 - 27 May 2021
Cited by 22 | Viewed by 5491
Abstract
Peptides have a three-dimensional configuration that can adopt particular conformations for binding to proteins, which are well suited to interact with larger contact surface areas on target proteins. However, low cell permeability is a major challenge in the development of peptide-related drugs. In [...] Read more.
Peptides have a three-dimensional configuration that can adopt particular conformations for binding to proteins, which are well suited to interact with larger contact surface areas on target proteins. However, low cell permeability is a major challenge in the development of peptide-related drugs. In recent years, backbone N-methylation has been a useful tool for manipulating the permeability of cyclic peptides/peptidomimetics. Backbone N-methylation permits the adjustment of molecule’s conformational space. Several pathways are involved in the drug absorption pathway; the relative importance of each N-methylation to total permeation is likely to differ with intrinsic properties of cyclic peptide/peptidomimetic. Recent studies on the permeability of cyclic peptides/peptidomimetics using the backbone N-methylation strategy and synthetic methodologies will be presented in this review. Full article
(This article belongs to the Special Issue Marine Cyclic Peptides: Isolation, Synthesis and Biological Activities)
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