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Advanced Bio-Inspired Materials for Biomedical Applications

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (20 June 2024) | Viewed by 1720

Special Issue Editors


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Guest Editor
Department of Life, Health and Environmental Sciences, University of L’Aquila, L'Aquila, Italy
Interests: morphology; microscopy; SEM; TEM; biomaterials; dental sciences
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Life Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy
Interests: anatomy; dentistry; anatomy teaching; innovation in education; oral surgery; regenerative dentistry; oral biofilm; biomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

the advancement of knowledge of the biology of cells, tissues and organs and the pathogenesis of the related diseases, lead in the last year to an increase of interest in the design and production of biomimetic and bioinspired materials. This particular type of biomaterials are defined as a material replicating the key features of natural materials and/or biological structures. Indeed, the emerging science of biomimetics, by means of tissue and design engineering technique, aims to take the biological principles of work and mimics into biomaterials able to interface with cells, tissues, and organs.

This Special Issue aims to present the latest works in the research and development, in form of original articles or reviews, of biomimetic and bioinspired materials, to solicit the most important findings, to highlight the left challenges, and to provide the perspectives on the future direction.

Prof. Dr. Guido Macchiarelli
Dr. Sara Bernardi
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials for biomedical applications 
  • bioinspired materials 
  • bioderived biosensors
  • biomimetic drug delivery systems
  • artificial organs
  • prosthetics
  • tissue-like materials
  • bioscaffolds

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Published Papers (1 paper)

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Research

18 pages, 7328 KiB  
Article
In Vitro Evaluation of Cellular Interactions with Nanostructured Spheres of Alginate and Zinc-Substituted Carbonated Hydroxyapatite
by Jessica Dornelas, Gisele Dornelas, Elena Mavropoulos Oliveira Tude, Carlos Fernando Mourão, Alexandre da Malta Rossi and Gutemberg Gomes Alves
Materials 2024, 17(16), 4092; https://doi.org/10.3390/ma17164092 - 17 Aug 2024
Viewed by 1189
Abstract
The increasing demand for effective bone regeneration materials drives the exploration of biomaterials with enhanced bioactivity and biocompatibility, such as zinc-substituted compounds. This study investigates the in vitro cellular interactions with nanostructured spheres composed of alginate/carbonated hydroxyapatite (CHA), compared to zinc-substituted CHA (ZnCHA). [...] Read more.
The increasing demand for effective bone regeneration materials drives the exploration of biomaterials with enhanced bioactivity and biocompatibility, such as zinc-substituted compounds. This study investigates the in vitro cellular interactions with nanostructured spheres composed of alginate/carbonated hydroxyapatite (CHA), compared to zinc-substituted CHA (ZnCHA). This work aimed to compare the physicochemical properties and biological effects of ZnCHA and CHA on osteoblasts. ZnCHA was synthesized using a wet chemical method, followed by characterization through X-ray diffraction, Fourier transform infrared spectroscopy, total organic carbon analysis, Wavelength-dispersive X-ray spectroscopy, and BET surface area analysis to assess ion release and structural changes. Biological evaluation was conducted using cell viability, proliferation, and biomineralization assays on osteoblasts. Results showed successful incorporation of zinc and carbonate, leading to reduced crystallinity and increased surface area. Cell viability and proliferation assays indicated ZnCHA’s cytocompatibility and enhanced osteoblastic activity, with increased mineralization nodules compared to CHA samples. The study concludes that ZnCHA composites are promising candidates for bone tissue engineering, demonstrating improved cytocompatibility and potential for further preclinical evaluations. Full article
(This article belongs to the Special Issue Advanced Bio-Inspired Materials for Biomedical Applications)
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