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Bone Tissue Engineering Materials: From Preparation to Properties
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Bone Tissue Engineering Materials: From Preparation to Properties

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: 20 February 2025 | Viewed by 5415

Special Issue Editor

Dr. Jakub Szabelski

E-Mail Website
Guest Editor
Department of Materials Science and Engineering, Lublin University of Technology, 20-618 Lublin, Poland
Interests: biomaterials; bone cements; adhesive joints; adhesive materials

Special Issue Information

Dear Colleagues,

This Special Issue titled "Materials for Bone Tissue Engineering: From Preparation to Properties" aims to present the latest research and development progress in the field of biomaterials designed specifically for bone tissue engineering, with a special focus on bone cements. Bone cements play a key role in orthopedic surgery and are essential for implant fixation and bone reconstruction. This Special Issue will therefore cover a wide range of aspects within this topic, including the development of innovative preparation techniques and methods for evaluating the properties and durability of bone cements.

We hope that this Special Issue will be a valuable resource for researchers, engineers and clinicians interested in the latest developments and future directions of biomaterials, particularly bone cements, in bone tissue engineering.

Dr. Jakub Szabelski
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • bone tissue engineering
  • bone cements
  • preparation techniques
  • properties and performance
  • surface modification
  • material degradation
  • biocompatibility
  • mechanical strength
  • porosity
  • antibiotics
  • controlled release

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Published Papers (4 papers)

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Research

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24 pages, 13440 KiB  
Article
Mechanical Properties, Drug Release, Biocompatibility, and Antibacterial Activities of Modified Emulsified Gelatin Microsphere Loaded with Gentamicin Composite Calcium Phosphate Bone Cement In Vitro
by Ming-Hsien Hu, Bo-Sin Shih, Shih-Ming Liu, Ssu-Meng Huang, Chia-Ling Ko and Wen-Cheng Chen
Materials 2024, 17(14), 3578; https://doi.org/10.3390/ma17143578 - 19 Jul 2024
Viewed by 742
Abstract
Bone defects are commonly addressed with bone graft substitutes; however, surgical procedures, particularly for open and complex fractures, may pose a risk of infection. As such, a course of antibiotics combined with a drug carrier is often administered to mitigate potential exacerbations. This [...] Read more.
Bone defects are commonly addressed with bone graft substitutes; however, surgical procedures, particularly for open and complex fractures, may pose a risk of infection. As such, a course of antibiotics combined with a drug carrier is often administered to mitigate potential exacerbations. This study involved the preparation and modification of emulsified (Em) crosslinking-gelatin (gel) microspheres (m-Em) to reduce their toxicity. The antibiotic gentamicin was impregnated into gel microspheres (m-EmG), which were incorporated into calcium phosphate bone cement (CPC). The study investigated the effects of m-EmG@CPC on antibacterial activity, mechanical properties, biocompatibility, and proliferation and mineralization of mouse progenitor osteoblasts (D1 cells). The average size of the gel microspheres ranged from 22.5 to 16.1 μm, with no significant difference between the groups (p > 0.05). Most of the oil content within the microspheres was transferred through modification, resulting in reduced cytotoxicity. Furthermore, antibiotic-impregnated m-EmG did not compromise the intrinsic properties of the microspheres and exhibited remarkably antibacterial effects. After combining with CPC (m-EmG@CPC), the microspheres did not significantly hinder the CPC reaction and produced the main product, hydroxyapatite (HA). However, the compressive strength of the largest microsphere content of 0.5 wt.% m-EmG in CPC decreased significantly from 59.8 MPa of CPC alone to 38.7 MPa of 0.5m-EmG@CPC (p < 0.05). The 0.5m-EmG@CPC composite was effective against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) in drug release and antibacterial tests. Compared with m-EmG alone, the 0.5m-EmG@CPC composite showed no toxicity to mouse fibroblast cells (L929). Additionally, the proliferation and mineralization of mouse osteoblastic osteoprogenitor cells (D1 cells) did not have a negative impact on the 0.5m-EmG@CPC composite over time in culture compared with CPC alone. Results suggest that the newly developed antibacterial 0.5m-EmG@CPC composite bone cement did not negatively affect the performance of osteoprogenitor cells and could be a new option for bone graft replacement in surgeries. Full article
(This article belongs to the Special Issue Bone Tissue Engineering Materials: From Preparation to Properties)
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25 pages, 4500 KiB  
Article
In Vivo Investigation of 3D-Printed Calcium Magnesium Phosphate Wedges in Partial Load Defects
by Elke Hemmerlein, Elke Vorndran, Anna-Maria Schmitt, Franziska Feichtner, Anja-Christina Waselau and Andrea Meyer-Lindenberg
Materials 2024, 17(9), 2136; https://doi.org/10.3390/ma17092136 - 2 May 2024
Viewed by 1039
Abstract
Bone substitutes are ideally biocompatible, osteoconductive, degradable and defect-specific and provide mechanical stability. Magnesium phosphate cements (MPCs) offer high initial stability and faster degradation compared to the well-researched calcium phosphate cements (CPCs). Calcium magnesium phosphate cements (CMPCs) should combine the properties of both [...] Read more.
Bone substitutes are ideally biocompatible, osteoconductive, degradable and defect-specific and provide mechanical stability. Magnesium phosphate cements (MPCs) offer high initial stability and faster degradation compared to the well-researched calcium phosphate cements (CPCs). Calcium magnesium phosphate cements (CMPCs) should combine the properties of both and have so far shown promising results. The present study aimed to investigate and compare the degradation and osseointegration behavior of 3D powder-printed wedges of CMPC and MPC in vivo. The wedges were post-treated with phosphoric acid (CMPC) and diammonium hydrogen phosphate (MPC) and implanted in a partially loaded defect model in the proximal rabbit tibia. The evaluation included clinical, in vivo µ-CT and X-ray examinations, histology, energy dispersive X-ray analysis (EDX) and scanning electron microscopy (SEM) for up to 30 weeks. SEM analysis revealed a zone of unreacted material in the MPC, indicating the need to optimize the manufacturing and post-treatment process. However, all materials showed excellent biocompatibility and mechanical stability. After 24 weeks, they were almost completely degraded. The slower degradation rate of the CMPC corresponded more favorably to the bone growth rate compared to the MPC. Due to the promising results of the CMPC in this study, it should be further investigated, for example in defect models with higher load. Full article
(This article belongs to the Special Issue Bone Tissue Engineering Materials: From Preparation to Properties)
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Review

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23 pages, 4717 KiB  
Review
Polysaccharide-Based Composite Systems in Bone Tissue Engineering: A Review
by Karina Niziołek, Dagmara Słota and Agnieszka Sobczak-Kupiec
Materials 2024, 17(17), 4220; https://doi.org/10.3390/ma17174220 - 27 Aug 2024
Viewed by 1062
Abstract
In recent years, a growing demand for biomaterials has been observed, particularly for applications in bone regenerative medicine. Bone tissue engineering (BTE) aims to develop innovative materials and strategies for repairing and regenerating bone defects and injuries. Polysaccharides, due to their biocompatibility, biodegradability [...] Read more.
In recent years, a growing demand for biomaterials has been observed, particularly for applications in bone regenerative medicine. Bone tissue engineering (BTE) aims to develop innovative materials and strategies for repairing and regenerating bone defects and injuries. Polysaccharides, due to their biocompatibility, biodegradability as well as bioactivity, have emerged as promising candidates for scaffolds or composite systems in BTE. Polymers combined with bioactive ceramics can support osteointegration. Calcium phosphate (CaP) ceramics can be a broad choice as an inorganic phase that stimulates the formation of new apatite layers. This review provides a comprehensive analysis of composite systems based on selected polysaccharides used in bone tissue engineering, highlighting their synthesis, properties and applications. Moreover, the applicability of the produced biocomposites has been analyzed, as well as new trends in modifying biomaterials and endowing them with new functionalizations. The effects of these composites on the mechanical properties, biocompatibility and osteoconductivity were critically analyzed. This article summarizes the latest manufacturing methods as well as new developments in polysaccharide-based biomaterials for bone and cartilage regeneration applications. Full article
(This article belongs to the Special Issue Bone Tissue Engineering Materials: From Preparation to Properties)
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17 pages, 3145 KiB  
Review
Cemented vs. Cementless Fixation in Primary Knee Replacement: A Narrative Review
by Mikołaj Wilczyński, Michał Bieniek, Przemysław Krakowski and Robert Karpiński
Materials 2024, 17(5), 1136; https://doi.org/10.3390/ma17051136 - 29 Feb 2024
Cited by 4 | Viewed by 2010
Abstract
Knee osteoarthritis (OA) is one of the leading causes of disability around the globe. Osteoarthritis is mainly considered a disease affecting the elderly. However, more and more studies show that sports overuse, obesity, or congenital disorders can initiate a pathologic cascade that leads [...] Read more.
Knee osteoarthritis (OA) is one of the leading causes of disability around the globe. Osteoarthritis is mainly considered a disease affecting the elderly. However, more and more studies show that sports overuse, obesity, or congenital disorders can initiate a pathologic cascade that leads to OA changes in the younger population. Nevertheless, OA mostly affects the elderly, and with increasing life expectancy, the disease will develop in more and more individuals. To date, the golden standard in the treatment of the end-stage of the disease is total joint replacement (TJR), which restores painless knee motion and function. One of the weakest elements in TJR is its bonding with the bone, which can be achieved by bonding material, such as poly methyl-methacrylate (PMMA), or by cementless fixation supported by bone ingrowth onto the endoprosthesis surface. Each technique has its advantages; however, the most important factor is the revision rate and survivor time. In the past, numerous articles were published regarding TJR revision rate, but no consensus has been established yet. In this review, we focused on a comparison of cemented and cementless total knee replacement surgeries. We introduced PICO rules, including population, intervention, comparison and outcomes of TJR in a PubMed search. We identified 783 articles published between 2010 and 2023, out of which we included 14 in our review. Our review reveals that there is no universally prescribed approach to fixate knee prostheses. The determination of the most suitable method necessitates an individualized decision-making process involving the active participation and informed consent of each patient. Full article
(This article belongs to the Special Issue Bone Tissue Engineering Materials: From Preparation to Properties)
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