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Development, Characterization, and Biological Performance of Materials for Bone, Periodontal,...
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Development, Characterization, and Biological Performance of Materials for Bone, Periodontal, and Dental Tissue Regeneration

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (30 August 2021) | Viewed by 11545

Special Issue Editor

Prof. France Lambert

E-Mail Website1 Website2
Guest Editor
1. Dental Biomaterial Research Unit (d-BRU), University of Liège, Liege, Belgium
2. Department of Periodontology and Oral surgery, University Hospital Center (CHU) of Liege, Liege, Belgium
Interests: dental biomaterials; tissue regeneration; dental implant; 3D-printed scaffolds; periodontology; oral surgery

Special Issue Information

Dear Colleagues,

While tooth loss or damage is widespread in aging societies, restorative materials and autologous grafts for managing dental tissues repair will be increasingly replaced by regenerative materials. The purpose of this Special Issue is to gather the most recent and major scientific progresses on materials specifically dedicated to intra-oral tissues regeneration, including alveolar bone, cementum, periodontal ligament, enamel, dentin, and pulp, as well as mucosal and gingival tissues. Whether they are under the form of nanoparticles, membranes, hydrogels or scaffolds, new materials perform better and better thanks to the development of manufacturing processes (e.g., 3D printing), nanotechnologies, and recent advances in stem cells-based strategies for tissue engineering. These are designed to be easy to handle, biocompatible, and to regenerate the targeted tissue, ideally associated to an improved healing time.

Moreover, this issue will focus on material development and investigations on materials biomechanical properties, surface topography and chemical composition that have to be meet for dental applications. Last but not least, the materials, as they aim to regenerate tissues, have to demonstrate biological performances in vivo, including clot stabilization, cell invasion or guidance as well as cell proliferation and differentiation to obtain a fully regenerated and functional tissue. 

We kindly invite you to submit a manuscript(s) for this Special Issue. Original research articles, short communications, and systematic reviews are all welcome.

Prof. France Lambert
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Biomaterial development
  • Biomaterial characterization
  • Biological performances
  • Intra-oral tissue regeneration
  • 3D-printing
  • Scaffolds
  • Membranes
  • Hydrogels
  • Nanotechnologies

Published Papers (3 papers)

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Research

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21 pages, 6003 KiB  
Article
Critical Role of Etching Parameters in the Evolution of Nano Micro SLA Surface on the Ti6Al4V Alloy Dental Implants
by Pankaj Chauhan, Veena Koul and Naresh Bhatnagar
Materials 2021, 14(21), 6344; https://doi.org/10.3390/ma14216344 - 23 Oct 2021
Cited by 9 | Viewed by 2453
Abstract
The surface of dental implants plays a vital role in early and more predictable osseointegration. SLA (sandblasted large grit and acid-etched) represents the most widely accepted, long-term clinically proven surface. Primarily, dental implants are manufactured by either commercially pure titanium (CP-Ti) or Ti6Al4V [...] Read more.
The surface of dental implants plays a vital role in early and more predictable osseointegration. SLA (sandblasted large grit and acid-etched) represents the most widely accepted, long-term clinically proven surface. Primarily, dental implants are manufactured by either commercially pure titanium (CP-Ti) or Ti6Al4V ELI alloy. The acid etch behavior of CP-Ti is well known and its effects on the surface microstructure and physicochemical properties have been studied by various researchers in the past. However, there is a lack of studies showing the effect of acid etching parameters on the Ti6Al4V alloy surface. The requirement of the narrow diameter implants necessitates implant manufacturing from alloys due to their high mechanical properties. Hence, it is necessary to have an insight on the behavior of acid etching of the alloy surface as it might be different due to changed compositions and microstructure, which can further influence the osseointegration process. The present research was carried out to study the effect of acid etching parameters on Ti6Al4V ELI alloy surface properties and the optimization of process parameters to produce micro- and nanotopography on the dental implant surface. This study shows that the Ti6Al4V ELI alloy depicts an entirely different surface topography compared to CP-Ti. Moreover, the surface topography of the Ti6Al4V ELI alloy was also different when etching was done at room temperature compared to high temperature, which in turn affected the behavior of the cell on these surfaces. Both microns and nano-level topography were achieved through the optimized parameters of acid etching on Ti6Al4V ELI alloy dental implant surface along with improved roughness, hydrophilicity, and enhanced cytocompatibility. Full article
(This article belongs to the Special Issue Development, Characterization, and Biological Performance of Materials for Bone, Periodontal, and Dental Tissue Regeneration)
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Review

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19 pages, 1678 KiB  
Review
Synthetic Material for Bone, Periodontal, and Dental Tissue Regeneration: Where Are We Now, and Where Are We Heading Next?
by Chia Wei Cheah, Nisreen Mohammed Al-Namnam, May Nak Lau, Ghee Seong Lim, Renukanth Raman, Peter Fairbairn and Wei Cheong Ngeow
Materials 2021, 14(20), 6123; https://doi.org/10.3390/ma14206123 - 15 Oct 2021
Cited by 51 | Viewed by 5138
Abstract
Alloplasts are synthetic, inorganic, biocompatible bone substitutes that function as defect fillers to repair skeletal defects. The acceptance of these substitutes by host tissues is determined by the pore diameter and the porosity and inter-connectivity. This narrative review appraises recent developments, characterization, and [...] Read more.
Alloplasts are synthetic, inorganic, biocompatible bone substitutes that function as defect fillers to repair skeletal defects. The acceptance of these substitutes by host tissues is determined by the pore diameter and the porosity and inter-connectivity. This narrative review appraises recent developments, characterization, and biological performance of different synthetic materials for bone, periodontal, and dental tissue regeneration. They include calcium phosphate cements and their variants β-tricalcium phosphate (β-TCP) ceramics and biphasic calcium phosphates (hydroxyapatite (HA) and β-TCP ceramics), calcium sulfate, bioactive glasses and polymer-based bone substitutes which include variants of polycaprolactone. In summary, the search for synthetic bone substitutes remains elusive with calcium compounds providing the best synthetic substitute. The combination of calcium sulphate and β-TCP provides improved handling of the materials, dispensing with the need for a traditional membrane in guided bone regeneration. Evidence is supportive of improved angiogenesis at the recipient sites. One such product, (EthOss® Regeneration, Silesden, UK) has won numerous awards internationally as a commercial success. Bioglasses and polymers, which have been used as medical devices, are still in the experimental stage for dental application. Polycaprolactone-TCP, one of the products in this category is currently undergoing further randomized clinical trials as a 3D socket preservation filler. These aforementioned products may have vast potential for substituting human/animal-based bone grafts. Full article
(This article belongs to the Special Issue Development, Characterization, and Biological Performance of Materials for Bone, Periodontal, and Dental Tissue Regeneration)
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24 pages, 3877 KiB  
Review
A Review on Multiscale Bone Damage: From the Clinical to the Research Perspective
by Federica Buccino, Chiara Colombo and Laura Maria Vergani
Materials 2021, 14(5), 1240; https://doi.org/10.3390/ma14051240 - 5 Mar 2021
Cited by 18 | Viewed by 3147
Abstract
The investigation of bone damage processes is a crucial point to understand the mechanisms of age-related bone fractures. In order to reduce their impact, early diagnosis is key. The intricate architecture of bone and the complexity of multiscale damage processes make fracture prediction [...] Read more.
The investigation of bone damage processes is a crucial point to understand the mechanisms of age-related bone fractures. In order to reduce their impact, early diagnosis is key. The intricate architecture of bone and the complexity of multiscale damage processes make fracture prediction an ambitious goal. This review, supported by a detailed analysis of bone damage physical principles, aims at presenting a critical overview of how multiscale imaging techniques could be used to implement reliable and validated numerical tools for the study and prediction of bone fractures. While macro- and meso-scale imaging find applications in clinical practice, micro- and nano-scale imaging are commonly used only for research purposes, with the objective to extract fragility indexes. Those images are used as a source for multiscale computational damage models. As an example, micro-computed tomography (micro-CT) images in combination with micro-finite element models could shed some light on the comprehension of the interaction between micro-cracks and micro-scale bone features. As future insights, the actual state of technology suggests that these models could be a potential substitute for invasive clinical practice for the prediction of age-related bone fractures. However, the translation to clinical practice requires experimental validation, which is still in progress. Full article
(This article belongs to the Special Issue Development, Characterization, and Biological Performance of Materials for Bone, Periodontal, and Dental Tissue Regeneration)
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