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Synthesis and Characterization of Hybrid Scaffolds in Bone Tissue Regeneration
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Synthesis and Characterization of Hybrid Scaffolds in Bone Tissue Regeneration

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (20 October 2022) | Viewed by 5272

Special Issue Editor

Dr. Byung Hoon Kim

E-Mail Website
Guest Editor
Dental Materials, Chosun University, Gwangju 61452, Korea
Interests: bone tissue engineering; 3D printing; 3D scaffolds; plasma surface modification

Special Issue Information

Dear Colleagues,

Bone scaffolds have been extensively used as bone substitutes to repair bone defects. Recently, there has been an increasing focus on developing processes for the production of ideal 3D scaffolds for bone regeneration. A variety of techniques are used in the fabrication of 3D scaffolds, and additive-manufacturing-based 3D-printing technology has attracted attention because of its advantages in designing and fabricating the scaffold architecture’s internal structure, shape, porosity, pore size and pore interconnectivity and external shapes.  

Various biomaterials have been investigated as scaffold materials for the repair of damaged bone tissue, including metals, ceramics, polymers (natural and synthetic), or their combinations. Since bioceramics have similar chemical and structural properties compared to the mineral phase of human bones, they have been extensively studied as biocompatible and osteoconductive materials for bone regeneration. Therefore, composite materials are extensively used as scaffold materials for bone regeneration. For example, polymer/bioceramic composites have been extensively considered as scaffold materials for bone tissue engineering due to the advantages of each material.

Aiming to highlight this concept, this Special Issue will focus on the synthesis and characterization of hybrid scaffolds for bone tissue regeneration.

We kindly invite you to submit a manuscript for this Special Issue. Full papers, communications, and reviews are welcome.

Dr. Byung Hoon Kim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bone tissue engineering
  • 3D scaffolds
  • 3D printing
  • bone regeneration
  • polymer/ceramic composite scaffolds
  • bone substitute materials
  • osteogenic differentiation

Published Papers (2 papers)

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Research

13 pages, 3288 KiB  
Article
Effect of Hydroxyapatite Nanoparticles and Nitrogen Plasma Treatment on Osteoblast Biological Behaviors of 3D-Printed HDPE Scaffold for Bone Tissue Regeneration Applications
by Hyun-Chul Park, Jaeyoung Ryu, Seunggon Jung, Hong-Ju Park, Hee-Kyun Oh and Min-Suk Kook
Materials 2022, 15(3), 827; https://doi.org/10.3390/ma15030827 - 21 Jan 2022
Cited by 11 | Viewed by 2116
Abstract
The need for the repair of bone defects has been increasing due to various causes of loss of skeletal tissue. High density polyethylenes (HDPE) have been used as bone substitutes due to their excellent biocompatibility and mechanical strength. In the present study, we [...] Read more.
The need for the repair of bone defects has been increasing due to various causes of loss of skeletal tissue. High density polyethylenes (HDPE) have been used as bone substitutes due to their excellent biocompatibility and mechanical strength. In the present study, we investigated the preosteoblast cell proliferation and differentiation on the adding nano-hydroxyapatite (n-HAp) particles into HDPE scaffold and treating HDPE/n-HAp scaffolds with nitrogen (N2) plasma. The three-dimensional (3D) HDPE/n-HAp scaffolds were prepared by fused modeling deposition 3D printer. The HDPE/n-HAp was blended with 10 wt% of n-HAp particle. The scaffold surface was reactive ion etched with nitrogen plasma to improve the preosteoblast biological response in vitro. After N2 plasma treatment, surfaces characterizations were investigated using Fourier transform infrared spectroscopy, scanning electron microscopy, and atomic force microscopy. The proliferation and differentiation of preosteoblast (MC3T3-E1) cells were evaluated by MTT assay and alkaline phosphatase (ALP) activity. The incorporation of n-HAp particles and N2 plasma surface treatment showed the improvement of biological responses of MC3T3-E1 cells in the HDPE scaffolds. Full article
(This article belongs to the Special Issue Synthesis and Characterization of Hybrid Scaffolds in Bone Tissue Regeneration)
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21 pages, 7014 KiB  
Article
Amine Plasma-Polymerization of 3D Polycaprolactone/β-Tricalcium Phosphate Scaffold to Improving Osteogenic Differentiation In Vitro
by Hee-Yeon Kim, Byung-Hoon Kim and Myung-Sun Kim
Materials 2022, 15(1), 366; https://doi.org/10.3390/ma15010366 - 4 Jan 2022
Cited by 9 | Viewed by 2689
Abstract
This study aims to investigate the surface characterization and pre-osteoblast biological behaviors on the three-dimensional (3D) poly(ε-caprolactone)/β-tricalcium phosphate (β-TCP) scaffold modified by amine plasma-polymerization. The 3D PCL scaffolds were fabricated using fused deposition modeling (FDM) 3D printing. To improve the pre-osteoblast bioactivity, the [...] Read more.
This study aims to investigate the surface characterization and pre-osteoblast biological behaviors on the three-dimensional (3D) poly(ε-caprolactone)/β-tricalcium phosphate (β-TCP) scaffold modified by amine plasma-polymerization. The 3D PCL scaffolds were fabricated using fused deposition modeling (FDM) 3D printing. To improve the pre-osteoblast bioactivity, the 3D PCL scaffold was modified by adding β-TCP nanoparticles, and then scaffold surfaces were modified by amine plasma-polymerization using monomer allylamine (AA) and 1,2-diaminocyclohexane (DACH). After the plasma-polymerization of PCL/β-TCP, surface characterizations such as contact angle, AFM, XRD, and FTIR were evaluated. In addition, mechanical strength was measured by UTM. The pre-osteoblast bioactivities were evaluated by focal adhesion and cell proliferation. Osteogenic differentiation was investigated by ALP activity, Alizarin red staining, and Western blot. Plasma-polymerization induced the increase in hydrophilicity of the surface of the 3D PCL/β-TCP scaffold due to the deposition of amine polymeric thin film on the scaffold surface. Focal adhesion and proliferation of pre-osteoblast improved, and osteogenic differentiation was increased. These results indicated that 3D PCL/β-TCP scaffolds treated with DACH plasma-polymerization showed the highest bioactivity compared to the other samples. We suggest that 3D PCL/β-TCP scaffolds treated with DACH and AA plasma-polymerization can be used as a promising candidate for osteoblast differentiation of pre-osteoblast. Full article
(This article belongs to the Special Issue Synthesis and Characterization of Hybrid Scaffolds in Bone Tissue Regeneration)
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