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Translational Research on Dental Materials
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Translational Research on Dental Materials

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (15 January 2022) | Viewed by 16761

Special Issue Editor

Prof. Dr. Michael Gasik

E-Mail Website
Guest Editor
Department of Chemical and Metallurgical Engineering, School of Chemical Engineering, Aalto University Foundation, FIN-00076 Espoo, Finland
Interests: biomaterials; medical devices; tissue engineering; dental; orthopedics

Special Issue Information

Dear Colleagues,

Despite the developments of materials for dental applications, there are still many challenges to be addressed. We think that dental biomaterials research needs to be brought closer to real conditions to interact closer with dental practice. Hence, we invite you to contribute to this Special Issue on “Translational Research in Dental Materials” aimed at highlighting the recent progress in dental biomaterials which have high relevance especially to unmet clinical needs.

We expect original papers on your research, development, and possibly clinical experience with various biomaterials (metals, ceramics, composites, polymers), addressing materials processing (also including additive or subtractive manufacturing and surface modification), properties, validation and testing, in silico design and optimization, in vitro and in vivo studies, as well as clinical experience and feedback. We anticipate your team has results and data which will be of a huge practical and scientific interest for the community and business in this challenging area.

Please feel free to contact me or the editor Ms. Judy Zhou [email protected] for extra information.

Prof. Dr. Michael Gasik
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Dental materials
  • Implants
  • Abutments
  • Restorations
  • Fixtures
  • Crowns
  • Ceramics
  • Metallic alloys
  • Polymers
  • Composites
  • Biomaterials preparation
  • Biomaterials testing and verification
  • Biomechanics of dental materials
  • In silico design and optimization
  • In vitro/in vivo research
  • Chairside procedures with biomaterials
  • Translational research
  • Clinical applications
  • Post-marketing follow-up/vigilance

Published Papers (6 papers)

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Research

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21 pages, 7782 KiB  
Article
Biomechanical Properties of Bone and Mucosa for Design and Application of Dental Implants
by Michael Gasik, France Lambert and Miljana Bacevic
Materials 2021, 14(11), 2845; https://doi.org/10.3390/ma14112845 - 26 May 2021
Cited by 8 | Viewed by 3646
Abstract
Dental implants’ success comprises their proper stability and adherence to different oral tissues (integration). The implant is exposed to different mechanical stresses from swallowing, mastication and parafunctions for a normal tooth, leading to the simultaneous mechanical movement and deformation of the whole structure. [...] Read more.
Dental implants’ success comprises their proper stability and adherence to different oral tissues (integration). The implant is exposed to different mechanical stresses from swallowing, mastication and parafunctions for a normal tooth, leading to the simultaneous mechanical movement and deformation of the whole structure. The knowledge of the mechanical properties of the bone and gingival tissues in normal and pathological conditions is very important for the successful conception of dental implants and for clinical practice to access and prevent potential failures and complications originating from incorrect mechanical factors’ combinations. The challenge is that many reported biomechanical properties of these tissues are substantially scattered. This study carries out a critical analysis of known data on mechanical properties of bone and oral soft tissues, suggests more convenient computation methods incorporating invariant parameters and non-linearity with tissues anisotropy, and applies a consistent use of these properties for in silico design and the application of dental implants. Results show the advantages of this approach in analysis and visualization of stress and strain components with potential translation to dental implantology. Full article
(This article belongs to the Special Issue Translational Research on Dental Materials)
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11 pages, 4146 KiB  
Article
Effects of Copper Surface Oxidation and Reduction on Shear-Bond Strength Using Functional Monomers
by Haruto Hiraba, Hiroyasu Koizumi, Akihisa Kodaira, Kosuke Takehana, Takayuki Yoneyama and Hideo Matsumura
Materials 2021, 14(7), 1753; https://doi.org/10.3390/ma14071753 - 2 Apr 2021
Cited by 8 | Viewed by 1760
Abstract
This study was conducted to clarify the influence of the copper surface oxidation and reduction on the shear-bond strength with functional monomers. Unheated copper specimens (UH; n = 88) were wet-ground. Three-quarters of the UH were then heated (HT). Two-thirds of the HT [...] Read more.
This study was conducted to clarify the influence of the copper surface oxidation and reduction on the shear-bond strength with functional monomers. Unheated copper specimens (UH; n = 88) were wet-ground. Three-quarters of the UH were then heated (HT). Two-thirds of the HT was then immersed in a hydrochloric acid solution (AC). Half of the AC was then reheated (RH). Each group was further divided into two groups (n = 11), which were primed by either 6-methacryloyloxyhexyl 2-thiouracil-5-carboxylate (MTU-6) or 10-methacryloyloxydecyl dihydrogen phosphate (MDP). The shear-bond strength tests were used for bonding with an acrylic resin. The surface roughness values and chemical states of the four groups were analyzed using a confocal scanning laser microscope and X-ray photoelectron spectroscopy (XPS). The shear-bond strengths of HT and RH were the lowest in the MTU-6-primed groups. The result of AC was significantly lower than others in the MDP-primed groups. The XPS results showed that the surfaces of UH and AC consisted of Cu2O and Cu. The surface changed to CuO upon heating. The presence or absence of copper-oxide films showed the opposite trends in the effectiveness of MTU-6 and MDP to improve bond strength. The results could elucidate the effects of functional monomers on copper-oxide films. Full article
(This article belongs to the Special Issue Translational Research on Dental Materials)
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14 pages, 4783 KiB  
Article
Development of Multifunctional Materials Based on Poly(ether ether ketone) with Improved Biological Performances for Dental Applications
by Vanessa Montaño-Machado, Pascale Chevallier, Linda Bonilla-Gameros, Francesco Copes, Chiara Quarta, José de Jesús Kú-Herrera, Florentino Soriano, Victoria Padilla-Gainza, Graciela Morales and Diego Mantovani
Materials 2021, 14(4), 1047; https://doi.org/10.3390/ma14041047 - 23 Feb 2021
Cited by 6 | Viewed by 2814
Abstract
The main target for the future of materials in dentistry aims to develop dental implants that will have optimal integration with the surrounding tissues, while preventing or avoiding bacterial infections. In this project, poly(ether ether ketone) (PEEK), known for its suitable biocompa-tibility and [...] Read more.
The main target for the future of materials in dentistry aims to develop dental implants that will have optimal integration with the surrounding tissues, while preventing or avoiding bacterial infections. In this project, poly(ether ether ketone) (PEEK), known for its suitable biocompa-tibility and mechanical properties for dental applications, was loaded with 1, 3, and 5 wt.% ZnO nanoparticles to provide antibacterial properties and improve interaction with cells. Sample cha-racterization by X-ray diffraction (XRD), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC) as well as mechanical properties showed the presence of the nanoparticles and their effect in PEEK matrices, preserving their relevant properties for dental applications. Al-though, the incorporation of ZnO nanoparticles did not improve the mechanical properties and a slight decrease in the thermal stability of the materials was observed. Hemocompatibility and osteoblasts-like cell viability tests showed improved biological performances when ZnO was present, demonstrating high potential for dental implant applications. Full article
(This article belongs to the Special Issue Translational Research on Dental Materials)
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12 pages, 2187 KiB  
Article
Enhancement of Gingival Tissue Adherence of Zirconia Implant Posts: In Vitro Study
by Alexandra Zühlke, Michael Gasik, Khalil Shahramian, Timo Närhi, Yevgen Bilotsky and Ilkka Kangasniemi
Materials 2021, 14(2), 455; https://doi.org/10.3390/ma14020455 - 19 Jan 2021
Cited by 6 | Viewed by 2289
Abstract
Prevention of bacterial inflammation around dental implants (peri-implantitis) is one of the keys to success of the implantation and can be achieved by securing the gingival tissue-abutment interface preventing penetration of bacteria. Modern dental practice has adopted zirconia abutments in place of titanium, [...] Read more.
Prevention of bacterial inflammation around dental implants (peri-implantitis) is one of the keys to success of the implantation and can be achieved by securing the gingival tissue-abutment interface preventing penetration of bacteria. Modern dental practice has adopted zirconia abutments in place of titanium, but the adhesion of gingival tissue to zirconia is inferior to titanium. The aim of this study was to assess and improve the adhesion of mucosal tissues to zirconia posts using sol-gel derived TiO2 coating following dynamic mechanical testing. The posts were cultivated with porcine bone-gingival tissue specimens in vitro for 7 and 14 days and then subjected to dynamic mechanical analysis simulating physiological loading at 1 Hz up to 50 μm amplitude. In parallel in silico analysis of stresses and strains have been made simulating “the worst case” when the fixture fails in osseointegration while the abutment still holds. Results show treatment of zirconia can lead to double interface stiffness (static shear stiffness values from 5–10 to 17–23 kPa and dynamic from 20–50 to 60–125 kPa), invariant viscostiffness (from 5–35 to 45–90 kPa·sα) and material memory values (increased from 0.06–0.10 to 0.17–0.25), which is beneficial in preventing bacterial contamination in dental implants. This suggests TiO2-coated zirconia abutments may have a significant clinical benefit for prevention of the bacterial contamination. Full article
(This article belongs to the Special Issue Translational Research on Dental Materials)
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Review

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22 pages, 2683 KiB  
Review
Electrophoretic Deposition of Biocompatible and Bioactive Hydroxyapatite-Based Coatings on Titanium
by Marija Djošić, Ana Janković and Vesna Mišković-Stanković
Materials 2021, 14(18), 5391; https://doi.org/10.3390/ma14185391 - 18 Sep 2021
Cited by 19 | Viewed by 2726
Abstract
Current trends in biomaterials science address the issue of integrating artificial materials as orthopedic or dental implants with biological materials, e.g., patients’ bone tissue. Problems arise due to the simple fact that any surface that promotes biointegration and facilitates osteointegration may also provide [...] Read more.
Current trends in biomaterials science address the issue of integrating artificial materials as orthopedic or dental implants with biological materials, e.g., patients’ bone tissue. Problems arise due to the simple fact that any surface that promotes biointegration and facilitates osteointegration may also provide a good platform for the rapid growth of bacterial colonies. Infected implant surfaces easily lead to biofilm formation that poses a major healthcare concern since it could have destructive effects and ultimately endanger the patients’ life. As of late, research has centered on designing coatings that would eliminate possible infection but neglected to aid bone mineralization. Other strategies yielded surfaces that could promote osseointegration but failed to prevent microbial susceptibility. Needless to say, in order to assure prolonged implant functionality, both coating functions are indispensable and should be addressed simultaneously. This review summarizes progress in designing multifunctional implant coatings that serve as carriers of antibacterial agents with the primary intention of inhibiting bacterial growth on the implant-tissue interface, while still promoting osseointegration. Full article
(This article belongs to the Special Issue Translational Research on Dental Materials)
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14 pages, 988 KiB  
Review
Customized Root-Analogue Implants: A Review on Outcomes from Clinical Trials and Case Reports
by Telma Dantas, Sara Madeira, Michael Gasik, Paula Vaz and Filipe Silva
Materials 2021, 14(9), 2296; https://doi.org/10.3390/ma14092296 - 29 Apr 2021
Cited by 12 | Viewed by 2566
Abstract
(1) It is estimated that 10% of the world’s population will need a dental implant in their lifetime. Despite all the advances in the comprehension of dental implant designs, materials and techniques, traditional implants still have many limitations. Customized root-analogue implants are, therefore, [...] Read more.
(1) It is estimated that 10% of the world’s population will need a dental implant in their lifetime. Despite all the advances in the comprehension of dental implant designs, materials and techniques, traditional implants still have many limitations. Customized root-analogue implants are, therefore, gaining increased interest in dental rehabilitation and are expected to not only preserve more hard and soft tissues but also avoid a second surgery and improve patient overall satisfaction. In this sense, the aim of this review was to collect and analyse the clinical trials and case reports on customized root-analogue implants available in the literature; (2) This review was carried out according to the PRISMA Statement. An electronic database search was performed using five databases: PubMed, Google Scholar, Medline, Science Direct, and Scopus. The following keywords were used for gathering data: custom-made, dental implants, root-analogue, anatomical, customized and tooth-like; (3) 15 articles meeting the inclusion criteria—articles reporting clinical trials, case reports or animal studies and articles with root-analogue implants and articles with totally customized implant geometries—were selected for the qualitative synthesis. The design and manufacturing techniques, implant material and surface treatments were assessed and discussed; (4) The performance of some root-analogue implants with specific features (i.e., macro-retentions) was successful, with no signs of infection, periodontitis nor bleeding during the follow-up periods. Full article
(This article belongs to the Special Issue Translational Research on Dental Materials)
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