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Novel Biomaterials for Soft and Hard Tissue Regeneration
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Novel Biomaterials for Soft and Hard Tissue Regeneration

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 5957

Special Issue Editor

Dr. Linh Nguyen

E-Mail Website
Guest Editor
Eastman Dental Institute, University College London, London, UK
Interests: biomaterials for soft and hard tissue regeneration; drug design and formulation; advanced delivery systems for hard tissue engineering; thermo-responsive polymer-based macro-carriers for stem cell expansion and harvesting; translational application
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The field of biomaterials has recently grown rapidly and will continue to emerge and expand the boundaries of the field of tissue engineering. Certain challenges are associated with such innovative biomaterials, such as the lack of sustainable and smart approaches for the synthesis and functionalization of biomaterials. Additionally, the understanding of cell–biomaterial interactions is an important aspect that needs to explored. Further investigations on pre-clinical performance to learn about cell behavior and tissue regeneration are needed, along with investigations on biomaterials.

Therefore, this Special Issue on “Novel Biomaterials for Soft and Hard Tissue Regeneration” will focus on original research papers related to engineered biomaterials for the regeneration of bone, cartilage, surrounding tissues (tendons, ligaments), and skin (such as in wound healing, wound dressing, and skin burns), as well as other soft tissues. Topics include—but are not limited to—the following:

  • Synthesis or processing of biomaterials or systems;
  • Characterization studies, including process–structure–property–function relationship investigations within the context of tissue engineering;
  • Functionalization strategies, including bio-, stimuli-responsive, smart, and multifunctionalization approaches within the context of tissue engineering;
  • Cell–material and stem cell–material interactions studies, including mechanobiology aspects within the context of tissue engineering;
  • Applications across various fields of tissue engineering, including in vitro and in vivo performance evaluation studies.

This Special Issue aims to provide a peer-reviewed forum for the publication of research on the topic of Biomaterials for Soft and Hard Tissue Regeneration, as well as the clinical applications. This Special Issue is open to all contributions across the areas of scaffolds, drug delivery systems, and growth factor delivery systems for repair, restoration, and regeneration of tissues.

Dr. Linh Nguyen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • soft tissue regeneration
  • hard tissue regeneration
  • cell–material and stem cell–material interactions
  • in vitro and in vivo performance evaluation studies

Published Papers (2 papers)

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Research

14 pages, 1820 KiB  
Article
Characterizations and Antibacterial Efficacy of Chitosan Oligomers Synthesized by Microwave-Assisted Hydrogen Peroxide Oxidative Depolymerization Method for Infectious Wound Applications
by Vinh Khanh Doan, Khanh Loan Ly, Nam Minh-Phuong Tran, Trinh Phuong-Thi Ho, Minh Hieu Ho, Nhi Thao-Ngoc Dang, Cheng-Chung Chang, Hoai Thi-Thu Nguyen, Phuong Thu Ha, Quyen Ngoc Tran, Lam Dai Tran, Toi Van Vo and Thi Hiep Nguyen
Materials 2021, 14(16), 4475; https://doi.org/10.3390/ma14164475 - 10 Aug 2021
Cited by 15 | Viewed by 2847
Abstract
The use of naturally occurring materials with antibacterial properties has gained a great interest in infected wound management. Despite being an abundant resource in Vietnam, chitosan and its derivatives have not yet been intensively explored for their potential in such application. Here, we [...] Read more.
The use of naturally occurring materials with antibacterial properties has gained a great interest in infected wound management. Despite being an abundant resource in Vietnam, chitosan and its derivatives have not yet been intensively explored for their potential in such application. Here, we utilized a local chitosan source to synthesize chitosan oligomers (OCS) using hydrogen peroxide (H2O2) oxidation under the microwave irradiation method. The effects of H2O2 concentration on the physicochemical properties of OCS were investigated through molecular weight, degree of deacetylation, and heavy metal contamination for optimization of OCS formulation. Then, the antibacterial inhibition was examined; the minimum inhibitory concentration and minimum bactericidal concentration (MIC and MBC) of OCS-based materials were determined against common skin-inhabitant pathogens. The results show that the local Vietnamese chitosan and its derivative OCS possessed high-yield purification while the molecular weight of OCS was inversely proportional and proportional to the concentration of H2O2, respectively. Further, the MIC and MBC of OCS ranged from 3.75 to less than 15 mg/mL and 7.5–15 mg/mL, respectively. Thus, OCS-based materials induce excellent antimicrobial properties and can be attractive for wound dressings and require further investigation. Full article
(This article belongs to the Special Issue Novel Biomaterials for Soft and Hard Tissue Regeneration)
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13 pages, 4663 KiB  
Article
CaCO3–Chitosan Composites Granules for Instant Hemostasis and Wound Healing
by Wei He, Xiaodong Huang, Jun Zhang, Yue Zhu, Yajun Liu, Bo Liu, Qilong Wang, Xiaonan Huang and Da He
Materials 2021, 14(12), 3350; https://doi.org/10.3390/ma14123350 - 17 Jun 2021
Cited by 9 | Viewed by 2344
Abstract
Excessive bleeding induces a high risk of death and is a leading cause of deaths that result from traffic accidents and military conflict. In this paper, we developed a novel porous chitosan–CaCO3 (CS–CaCO3) composite material and investigated its hemostatic properties [...] Read more.
Excessive bleeding induces a high risk of death and is a leading cause of deaths that result from traffic accidents and military conflict. In this paper, we developed a novel porous chitosan–CaCO3 (CS–CaCO3) composite material and investigated its hemostatic properties and wound healing performance. The CS–CaCO3 composites material was prepared via a wet-granulation method. Granulation increases the infiltrating ability of the CS–CaCO3 composites material. The improved water absorption ability was enhanced to 460% for the CS–CaCO3 composites material compared to the CaCO3 or chitosan with only one single component. The coagulation studies in vivo illustrated that the blood clotting time was greatly reduced from 31 s for CaCO3 to 16 s for the CS–CaCO3 composite material. According to the results of the wound healing experiments in rats, it was found that the CS–CaCO3 composite material can promote wound healing. The CS–CaCO3 composite material could accelerate wound healing to a rate of 9 days, compared with 12 days for the CaCO3. The hemostatic activity, biocompatibility, and low cost of CS–CaCO3 composite material make it a potential agent for effective hemostatic and wound healing materials. Full article
(This article belongs to the Special Issue Novel Biomaterials for Soft and Hard Tissue Regeneration)
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